https://www.selleckchem.com/products/verubecestat.html 05%, 5.07% and 5.24%. Compared with the control, the modified biochar decreased the relative abundance of Actinobacteriota and Chloroflex by 6.81% and 2.19%, and increased the relative abundance of Proteobacteria and Acidobacteriota by 7.34% and 12.52%. Correlation analysis shows that soil bulk density and water content may be important related factors that affect bacterial community structure. This study provides a theoretical basis for the directional control of modified biochar in the soil microecological environment in plastic greenhouse, which is conducive to healthy and sustainable farming. This study provides a theoretical basis for the directional control of modified biochar in the soil microecological environment in plastic greenhouse, which is conducive to healthy and sustainable farming. The interplay between systemic inflammation, activity of lymphoid organs and lymphoma activity in CD19-targeting chimeric antigen receptor (CAR)-T-cell immunotherapy, and its significance for response and toxicity, is not well defined. Using serial F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT), metabolic parameters of lymphoma and lymphoid organs were analyzed in ten patients receiving Tisagenlecleucel (an autologous CD19 CAR-T cell product) for relapsed or refractory diffuse large B-cell lymphoma. The prevalence and severity of toxicity (e.g., neurotoxicity) were noted. Achieving remission required early metabolic response (P = 0.0476). Early suppression of metabolic activity of lymphoid organs (spleen, P = 0.0368; lymph nodes, P = 0.0470) was associated with poor outcome. Lymphoma metabolic activity was significantly higher in patients with neurotoxicity (P = 0.0489). Early metabolic changes in lymphoma lesions and off-target lymphoid organs parallel medium-term response to CAR-T-cell therapy. PET can identify patients at risk for severe toxicity. Early metabolic changes in lym