5% vs 6.7%, P=0.001), resulting in a 4-fold decrease in VA-related complications. In 204 consecutive patients who underwent VM-facilitated USG-VA, FV diameters significantly increased during VM in both vertical (mean [SD] 10.1[3]mm vs 14.4[3.2]mm; P less then 0.001) and horizontal axis (10.6[2.9]mm vs 14.5[3.2]mm, P less then 0.001). This led to a mean (SD) 38% increase in EAA from 0.8(0.2)cm2 at baseline to 1.1(0.2)cm2 during VM (P less then 0.001). CONCLUSIONS USG-VA for EPS and/or CA is feasible. Complication rates using USG-VA are low and benign. VM is a simple way to significantly increase EAA of femoral vein and can support USG-VA in difficult cases.BACKGROUND Circumferential pulmonary vein isolation (CPVI) may affect heart rate variability (HRV) via incidental lesion of parasympathetic ganglia. AIMS We studied the pattern of HRV parameters changes and relationship between 1-year HRV change post-CPVI and atrial fibrillation (AF) recurrence. METHODS   One hundred consecutive patients undergoing CPVI for paroxysmal AF were enrolled (mean [SD] age 56.0 [11.2] years, 61 males). HRV was measured the day before and after CPVI, and 1, 3, 6 and 12 months post-CPVI using 24-h Holter-recording. RESULTS During the 33-month median follow-up 38 patients experienced a late AF recurrence (LRAF). Compared with the pre-CPVI values, HRV was significantly attenuated at 1-day post-CPVI in all patients. However, at 3 to 6 months post-CPVI, all HRV parameters remained significantly attenuated for 12 months post-CPVI in LRAF-free patients but not in those with LRAF. On multivariate Cox-analysis, early AF recurrence within the blanking period (HR 4.87, P 25 ms versus ≤25 ms (Log-Rank p=0.004). CONCLUSIONS Sustained parasympathetic denervation during 12 months after CPVI was a marker of successful CPVI, whereas a 3-month post-CPVI SDNN reduction (ΔSDNN(post-CA[3 m])) of ≤ 25 ms predicted LRAF occurrence.BACKGROUND Telbivudine (LdT) and tenofovir (TDF) are widely used in pregnant women to prevent vertical transmission; however, limited data are available on the differences in clinical efficacy and safety between the two drugs. METHODS A total of 307 hepatitis B e antigen (HBeAg)-positive pregnant women with complete follow-up data were enrolled, the patients with alanine aminotransferase (ALT) levels 0.05). CONCLUSIONS This study revealed that the clinical efficacy in LdT- or TDF-treated HBeAg-positive Chinese pregnant women is similar, and gastrointestinal adverse effects occurred more frequently in TDF-treated patients.BACKGROUND Interactive digital technology use is integral to adolescents' lives and has been associated with both health benefits and risks. Previous studies have largely focused on measuring the quantity of technology use or understanding the use of specific platforms. To better understand adolescents' interactive digital technology use, we need new approaches that consider technology interactions and their importance. OBJECTIVE This study aimed to develop an assessment tool to evaluate adolescents' digital technology interactions and their perceived importance.  https://www.selleckchem.com/products/monastrol.html  METHODS We used a validated scale development approach comprising 2 initial steps to create an item pool item pool development and item pool refinement. These steps relied upon empirical literature review and an expert convening. We then evaluated the item pool using a Web-based survey. Data were collected via Qualtrics panel recruitment from a national sample of 12- to 18-year-olds. Participant data were randomly split into a development subsample fffline environment, and (3) technology for social connection. CONCLUSIONS The resulting Adolescents' Digital Technology Interactions and Importance (ADTI) scale is a promising and psychometrically validated tool for identifying the importance of distinct technology interactions. The scale is informed by relevant theory and expert input. The 3 subscales have utility for future studies to understand whether certain subscale score ranges are associated with health or well-being outcomes. ©Megan A Moreno, Kole Binger, Qianqian Zhao, Jens Eickhoff. Originally published in the Journal of Medical Internet Research (http//www.jmir.org), 12.02.2020.BACKGROUND Immigrants to Canada belonging to ethnocultural minority groups are at increased risk of developing diabetes and complications, including diabetic retinopathy, and they are also less likely to be screened and treated. Improved attendance to retinopathy screening (eye tests) has the potential to reduce permanent complications, including blindness. OBJECTIVE This study aims to identify the barriers and enablers of attending diabetic retinopathy screening among ethnocultural minority immigrants living with diabetes in Quebec and Ontario, Canada, to inform the development of a behavior change intervention to improve diabetic retinopathy screening attendance. METHODS The research question draws on the needs of patients and clinicians. Using an integrated knowledge translation approach, the research team includes clinicians, researchers, and patient partners who will contribute throughout the study to developing and reviewing materials and procedures, helping to recruit participants, and disseminating fiDecember 2017, and the research ethics board approved the conduct of the study as of January 13, 2018. Data collection then began in April 2018. As of August 28, 2018, we have recruited 22 participants, and analysis is ongoing, with results expected to be published in 2020. CONCLUSIONS Findings from this study will inform the codevelopment of theory-informed, culturally- and linguistically-tailored interventions to support patients in attending retinopathy screening. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID) DERR1-10.2196/15109. ©Maman Joyce Dogba, Michael H Brent, Catherine Bach, Sarah Asad, Jeremy Grimshaw, Noah Ivers, France Légaré, Holly O Witteman, Janet Squires, Xiaoqin Wang, Olivera Sutakovic, Mary Zettl, Olivia Drescher, Zack van Allen, Nicola McCleary, Marie-Claude Tremblay, Stefanie Linklater, Justin Presseau. Originally published in JMIR Research Protocols (http//www.researchprotocols.org), 12.02.2020.