Because of insufficient data about their benefit-risk ratio in real life, drugs used for Alzheimer's disease (AD; cholinesterase inhibitors and memantine) were withdrawn from the list of reimbursable drugs in France on 1 August 2018.
 
  In this context, this study aimed to investigate the effects of the removal of AD drugs from the list of reimbursed drugs among patients followed in memory centres in France, in terms of prevalence and factors associated with drug discontinuation and evolution of disease management and cognition after drug discontinuation.
 
  This is an observational study based on data from the National Alzheimer Data Bank ('Banque Nationale Alzheimer' [BNA]), which centralizes information about patients consulting in memory centres. The drug discontinuation rate was estimated among patients receiving AD drugs at the last visit before the end of reimbursement. Factors associated with drug discontinuation were investigated among sociodemographic and disease characteristics, as well as among ththe evolution of MMSE score.
 
  This study provides real-life information about the use of AD drugs after they were withdrawn from reimbursement in France and shows that drug discontinuation was limited among patients followed in memory centres and accompanied by increased use of other healthcare resources.
 This study provides real-life information about the use of AD drugs after they were withdrawn from reimbursement in France and shows that drug discontinuation was limited among patients followed in memory centres and accompanied by increased use of other healthcare resources.Schools can be a setting to address mental health needs of sexual and gender minority (SGM) youth. Gender-Sexuality Alliances (GSAs), as extracurricular support groups, provide an existing structure that could be leveraged to reach SGM youth and deliver services.  https://www.selleckchem.com/products/loxo-195.html  Nevertheless, limited data indicate the prevalence of depression and anxiety among GSA members, how often GSAs discuss mental health, or their receptivity to resources. Participants in the current study were 580 youth (Mage = 15.59; 79% sexual minority, 57% cisgender female; 68% White) and 58 advisors in 38 GSAs purposively sampled across Massachusetts. Youth completed established measures of depression and anxiety; advisors reported how frequently their GSAs discussed mental health; and both reported their interest in mental health materials. Among youth, 70.1% scored above the threshold indicating probable mild depression, and 34.4% scored above the threshold suggesting concerning anxiety. Adjusted odds ratios indicated that the odds of depression and anxiety were higher for SGM members relative to heterosexual and cisgender members, particularly among youth reporting SGM identities that have been underrepresented. GSAs discussed mental health with some frequency over the school year. Youth and advisors expressed strong interest in resources. Findings support the case for developing selective and indicated school-based prevention programming for youth in GSAs to address their mental health needs.Since Frege, mental content (conscious content) has been distinguished from the meaning of natural language and not regarded mental content as the meaning of language expression. This anti-psychological view cuts off the connection between the meaning of language and mental content, giving rise to the failures in solving the problems of mind. Instead of thinking about linguistic meaning and mental content separately, philosophers of mind put more emphasis on mental content and even equate the meaning of linguistic expressions with it. Therefore, the issues that what the relationship between linguistic meaning and mental content is and how they are connected are not well answered so far. The author argues in this paper that 1) People attach meaning to symbols through communication activities when they have mental contents, thus forming the language, which is also a process of achieving psychological certainty in turn; 2) the relationship between linguistic meaning and mental content is similar to the interdependent relationship between monetary value and the use value of commodities. Without the latter, the former will lose its source, and the former also affects the latter. Philosophers of mind pay little attention to the interplay between language and mental content. Based on the above arguments and previous theories, this paper conceives a general model of the generation of linguistic meaning.This article stems from an interest taken in discussing the usage of the terms ambivalence and ambiguity, which are very present in Psychology's publications and savoir faire. It is important to reiterate that in common sense and even in scientific publications these terms are often used as synonyms or notions of little conceptual delimitation. The relevance of such differentiation is proposed once these notions participates of the emergence of the new in human subjective experience, and, in a methodological approach, ambiguity and ambivalence are dimensions that leads the researcher goes beyond a repetitive sterile description of the subject's speech, moving towards new perspectives of the psychological data. This paper aims to retrieve the qualifying power of such notions by making a broader reflection on the functions of language in the production of interpretive realities. We also propose to bring up a reflection about ambiguity in the construction of meaning and to reiterate ambivalences as inherent to human nature, its affective record and the process of human becoming. As a way to explain the proposed themes, we will analyse an excerpt from the documentary "Últimas Conversas", produced by the Brazilian filmmaker Eduardo Coutinho, in which high school students from public state schools in Rio de Janeiro tell their stories, speaking of dreams and shared challenges. The character Rafaela was selected for this article because of the emergence of unspeakable emotions from her narrative about an expected future as a promise of reconciliation with the alterity of her life story.Cancer research has led to unprecedented advances in treatment in recent decades. Physician-scientists have played a crucial role in these advances given their unique perspective at the intersection between basic research and clinical care, though their representation in cancer research has been in progressive decline. Cancer research programs that feature strong mentorship at the medical student level are associated with increased likelihood of alumni choosing a cancer research career path. In an effort to increase the cancer research medical student training pipeline, senior research faculty from the Tisch Cancer Institute (TCI) at the Icahn School of Medicine at Mount Sinai (ISMMS) developed the TCI Scholars Program, a rigorous mentored research training program funding medical students' summer research. This program is currently in its third year and has garnered significant interest among mentors and students alike from all four TCI Cancer Center Support Grant (CCSG)-funded research programs. Herein, we describe the development, implementation, evaluation, and major outcomes of this program.