https://www.selleckchem.com/ferroptosis.html A visual analog scale (VAS) on pain and the State-Trait Anxiety Inventory (STAI TX-1) were used to collect the data. The anxiety scores and pain levels were reduced in the intervention groups in comparison to the control group (P < .001). The anxiety scores weren't significantly different between the 2 intervention groups (P > .05), and the pain levels on the second day in intervention group 2 were lower than those of intervention group 1 (P < .05). While the pain levels were reduced in all groups (P < .001), the anxiety scores increased in the control group on the second day (P < .05) and decreased in the 2 intervention groups (P < .001). Music therapy can play an effective role in reducing pain and anxiety levels. Music therapy can play an effective role in reducing pain and anxiety levels. Evidence from multiple studies has revealed that it's meaningful to evaluate the clinical significance of CD146 because it's related to an early diagnosis of chronic renal failure as well as to the severity of illness and the patient's prognosis. The current study intended to evaluate the therapeutic effects of Shendibushen on the clinical parameters of blood and urine and on fibrosis in the kidney in a rat model, using simulated renal tissue fibrosis that was surgically induced with unilateral ureteral obstruction (UUO). Also, our research team intended to analyze the metabolic pathway activated by Shendibushen both in rat and human kidneys through use of the Kyoto Encyclopedia of Genes and Genomes (KEGG) database and the GeneNetwork. The aim is to discover if a connection existed between CD146 and key genes in these pathways. The research team conducted an animal study in Wistar rats. The rats were divided into 5 groups of 14 animals each (1) blank control group, (2) sham control group, (3) model grecreased the degree of renal interstitial fibrosis in the UUO rat model and reduced the serum creatinine, blood urea nitrogen, microalb