https://www.selleckchem.com/products/citarinostat-acy-241.html 09, 95% CI 1.06, 1.12), first trimester (OR=1.13, 95% CI 1.10, 1.17) and second trimester (OR=1.13, 95% CI 1.09, 1.17) periods. Effect estimates increased with adjustment for NO and O . We observed modest increases in odds of GDM for IQR increases in first trimester ammonium ion PM (OR=1.03, 95% CI 1.00, 1.05) and sulfate PM (OR=1.03, 95% CI 1.00, 1.05) exposures, as well as preconception Cr PM exposures (OR=1.05, 95% CI 1.02, 1.07). Exposures to PM , before and during pregnancy were associated with elevated odds of GDM. Mitigating air pollution exposures may reduce the risk of GDM and its long-term implications for maternal and child health. Exposures to PM2.5, before and during pregnancy were associated with elevated odds of GDM. Mitigating air pollution exposures may reduce the risk of GDM and its long-term implications for maternal and child health.Waterborne pathogens and their associated diseases are major threats to public health, and surveillance of pathogens and identification of the sources of pollution are imperative for preventing infections. However, simultaneously quantitative detection of multiple pathogens and pollution sources in water environments is the major challenge. In this study, we developed and validated a highly sensitive (mostly >80%) and highly specific (>99%) high-throughput quantitative PCR (HT-qPCR) approach, which could simultaneously quantify 68 marker genes of 33 human pathogens and 23 fecal markers of 10 hosts. The HT-qPCR approach was then successfully used to investigate pathogens and fecal pollution in marine recreational water samples of Xiamen, China. Totally, seven pathogenic marker genes were found in 13 beach bathing waters, which targeted Acanthamoeba spp., Clostridium perfringens, enteropathogenic Escherichia coli, Klebsiella pneumoniae, Vibrio cholera/V. parahaemolyticus and Legionella spp.. Fecal markers from human and dog were the most frequently detected,