For both liver lobes, Friedman's test followed by Bonferroni-adjusted Wilcoxon signed-rank test revealed that VIC values differed significantly when extracted from ROIs placed at the 4 different timepoints. The Page's L test for multiple comparison revealed a significant growing trend for VIC, from baseline acquisition to the fourth and last time point post-contrast agent injection.
 
  The extraction of hepatic VIC in healthy subjects was found to be significantly influenced by the DECT time point chosen for the extrapolation of the VIC values.
 The extraction of hepatic VIC in healthy subjects was found to be significantly influenced by the DECT time point chosen for the extrapolation of the VIC values.Sea-level rise will have unknown effects on the structure and function of valuable tidal freshwater floodplains. One reason for this knowledge gap is our poor constraint on the physical controls on complex floodplain inundation and circulation processes. Here, a high-resolution light detection and ranging (lidar) digital elevation model (DEM) is applied to fine-scale numerical simulations of flow and tracer exchange in a 0.43 km2 river floodplain in Southeast Florida, USA. The sequence of inundation and associated circulation patterns is assessed at 1-hour intervals of the rising and falling tide in the context of floodplain geomorphic structure. The depth averaged velocity vectors show concomitant flow divergence and convergence over small spatial scales, and this complexity arises from the submergence and emergence of subtle floodplain topography over the tidal cycle. Tracer exchange and associated residence times highlight the controls of floodplain topography on water storage at the end of the ebb cycle, or during low river stages. The effects of a 0.2 m and 0.5 m increase in mean sea-level on inundation extent and water retention times were also assessed. Percent change in inundated area and associated e-folding times reveal greater lateral inundation extent and a 20% increase in water retention times with up to a 0.5 m increase in mean sea-level. This work reveals the topographic influence on how, when, and where sea-level rise will impact the freshwater floodplain through increased hydro period and salt-water intrusion, and the importance of evaluating floodplain restoration benefits in the context of fine-scale surface flow processes and sea-level rise.The COVID-19 pandemic has been implicated in several mental health challenges faced by many people. These challenges can also arise due to the fear of being infected with COVID-19 and engaging in preventative behavior. This study investigated the mediating role of post-traumatic stress symptomology and psychological distress in the relationship between fear of COVID-19 and preventive health behavior. A sample of 1172 individuals (mean age = 22.9 years, 54.5% females) participated in the online survey. Correlation analysis revealed that preventive health behavior has a positive relationship with fear of COVID-19 and post-traumatic stress symptomology but a negative relationship with psychological distress. Further analysis indicated that post-traumatic stress symptomology and psychological distress mediated the relationship between fear of COVID-19 and preventive health behavior. Post-traumatic stress symptomology caused by the fear of COVID-19 could contribute to improving preventive health behavior while psychological distress caused by the fear of COVID-19 tends to hinder preventive health behavior.  https://www.selleckchem.com/products/caerulein.html  It is recommended that public and private agencies should assist in promoting COVID-19 targeted education. Attention should also be focused on people's mental health status as means of preventing COVID-19.This study investigated the effects of COVID-19-related social distancing practices on parents and children's mental health and explored joint parent-child activities and coping strategies among Arab families in Qatar. The sample of 308 parents answered self-reported questionnaires regarding their mental health, coping strategies, activities with their children, social distancing practices, and their children's mental health. Pearson's correlation coefficient and structural equation modeling were carried out. The results showed a significant positive correlation between social distancing and parents' activities with their children and their coping strategies, as well as between parents' mental health, activities with their children, children's mental health, and parents' coping strategies. Path analysis showed that social distancing practices influence both parents' and children's mental health through parents' activities with children and their coping strategies. Our findings revealed how living under stressful conditions, such as COVID-19, could enhance the mental health of family members.The specific nature of harm and functional impairment in the context of gaming disorder (GD) has received limited attention. In this study, we present one of the first concerted attempts to measure the types and degree of harm experienced by people displaying signs of problem gaming. Attempts were made to assess the extent to which types of harm were attributable to gaming as opposed to other factors. The study also investigated potential behavioural indicators of harmful involvement, including exposure to loot boxes. A sample of 471 regular gamers (M = 380, F = 73), recruited through the online platform Prolific, completed a survey where problem gaming was identified using Petry et al.'s (2014) checklist. Individuals who met the cut-off for gaming disorder scored higher than the non-problem group on most dimensions of harm, with physical and psychological types being the most common issues. Loot box expenditure was low (M = $25 in 3 months, for the 10.8% of respondents who played loot boxes) but significantly positively associated with the degree of gaming-related financial harm. This study shows that problem gaming is most strongly associated with physical or psychological harm and that financial harms may manifest in gaming activities that facilitate continuous spending options.