https://www.selleckchem.com/products/ll37-human.html Multivariable models demonstrated that close margins (< 2mm) were associated with an increased risk of recurrence when compared to margins ≥ 2mm in width whether women received radiation (HR 1.98 CI 0.87-4.54) or not (HR 1.32 CI 0.27-6.49), but confidence intervals were wide. In this study, patients with DCIS and close margins were less likely to experience recurrence after routine re-excision to margins greater than 2mm. In this study, patients with DCIS and close margins were less likely to experience recurrence after routine re-excision to margins greater than 2 mm.The aim of this study was to investigate the influence of various irrigants on the dislodgement resistance of MTA Repair HP, MTA Angelus, and MTA Flow to root dentin. Three slices (1.0 ± 0.1 mm) were prepared from the middle third of 20 human maxillary anterior teeth. On each dentin disc, three perpendicular simulated perforation holes with a standardized 0.8 mm diameter were created. The sections from the same root were distributed arbitrarily into three groups (n = 20) for smear layer removal procedure ethylenediaminetetraacetic acid (EDTA), chitosan-based silver nanoparticles (AgNPs-chitosan), and maleic acid (MA). Afterwards, the holes were randomly filled with one of the three investigated cements. The samples were submitted to the push-out test using a universal measuring system. Kruskal-Wallis and Mann-Whitney U tests were used to assess statistical differences among the groups. When the results were evaluated, it was found that the types of cement and chelating agents significantly affected the dislocation resistance (P  less then  0.05). EDTA provided a higher dislocation resistance with the investigated cements in comparison to MA and AgNPs-chitosan (P  less then  0.05). Furthermore, it was observed that MTA Flow and MTA Angelus presented improved dislocation resistance values than the MTA Repair HP when used with EDTA (P  less then  0.05).