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 Lymphomatoid granulomatosis (LYG) is a rare, extranodal B-cell lymphoproliferative disorder. The disease commonly presents with nonspecific symptoms and imaging features, making the diagnosis and therapeutic response assessment difficult. While histopathology is the mainstay of diagnosis, different imaging modalities such as computed tomography (CT), magnetic resonance imaging, or F18-fluorodeoxyglucose positron emission tomography/computed tomography (F-18 FDG PET/CT) can help in identifying the different organs involved. We present a case of LYG, post chemotherapy in remission for the past 5 years, presenting with symptoms of disease recurrence. Copyright © 2020 Indian Journal of Nuclear Medicine.We present fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET-CT) findings in an extremely rare case of penile metastasis from renal cell carcinoma. A 66-year-old male, a known case of renal cell carcinoma, underwent FDG PET-CT.  https://www.selleckchem.com/Proteasome.html  The scan showed metabolically active cervical lymph nodes, lytic skeletal lesions, deposit in the left adrenal gland, and nodules in the bilateral lungs, indicating metastatic disease. In addition, a hypermetabolic lesion was seen in the corpus cavernosum of the shaft of the penis, suggestive of penile metastasis. Follow-up PET-CT after tyrosine kinase inhibitor therapy showed reduction in size and metabolic activity of all previously seen lesions including penile lesion, suggestive of favorable response to therapy. Copyright © 2020 Indian Journal of Nuclear Medicine.Extraskeletal tracer uptake in methylene diphosphonate (MDP) bone scan is not a common finding. There have been several case reports in the literature showing diffuse splenic uptake in MDP bone scan. We present a case of sickle cell disease, which showed diffuse splenic uptake on MDP whole-body bone scan. Copyright © 2020 Indian Journal of Nuclear Medicine.Melanomas are usually cutaneous in origin but rarely can also arise from the mucosal linings in the body. Sinonasal melanomas arise from the mucosa of the nasal cavity and paranasal sinuses, which account for approximately 50% of mucosal melanomas in the body. 18F fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET/CT) has proven its role in malignant melanoma in staging especially in stage III and IV disease, restaging, assessing response to therapy and had affected in treatment change in significant number of cases. We present a case of sinonasal melanoma who underwent FDG PET/CT for staging and showed cervical lymph node and marrow metastases. Copyright © 2020 Indian Journal of Nuclear Medicine.Gated imaging, as a technically demanding procedure, requires special attention and effort to fulfill the technical adequacy and accuracy of the study, based on the available standard guidelines. One of the essential requirements to be met by both technologists and physicians, in nuclear cardiology, is triggering and synchronization as a fundamental subject of gating. There are many sources of gating errors that produce imaging artifacts and, in some occasions, render the images uninterpretable or the quantitative analyses less accurate. Sufficient knowledge of recognition of these artifacts and understanding of their related mechanisms (from physical and technical perspectives) enable the technologists and physicians to promote their performance in daily practice. In this article, intended as a readily practical technical review for nuclear medicine practitioners, it is aimed to present the technical and computer aspects of triggering and synchronization as well as the related errors during imaging. Copyright © 2020 Indian Journal of Nuclear Medicine.Myocardial perfusion single-photon emission computed tomography (SPECT) as a common imaging procedure in nuclear medicine laboratories may encompass findings in the heart or beyond it, in the thorax or abdomen, which may be related or unrelated to the symptoms of the patients. Sometimes, these findings may be discovered incidentally. In the present article, it is aimed to present some less frequent cardiac and extracardiac findings including radiolabeled emboli, transposition of great arteries, breast prosthesis, breast tissue uptake, pericardial effusion, hiatal hernia, hepatocellular carcinoma, ascites, aortic aneurysm, splenomegaly, and polycystic kidney disease during 99mTc-methoxyisobutylisonitrile myocardial perfusion SPECT with their radiological correlates. Copyright © 2020 Indian Journal of Nuclear Medicine.Objective The objective of this study is to assess the efficacy of Yttrium-90 (Y-90) radiation synovectomy in decreasing the recurrent bleeding episodes in hemophilic joints. Subjects and Methods A retrospective analysis of patients who had Y-90 synovectomy from January 2001 to January 2016 was done. Among them, patients with minimum follow-up of 6 months were selected. The response in terms of decrease in the number of bleeding episodes was evaluated.  https://www.selleckchem.com/Proteasome.html  Results A total of 167 patients (243 joints) with hemophilia had radiation synovectomy over 15 years. Those with a minimum follow-up of 6 months were 155 joints (115 patients). The age ranged from 5 to 43 years and included 113 male and two female patients. Data for 11 joints were unavailable as these patients were lost to follow-up. The assessment of response for the remaining 144 joints was done based on the data available for different follow-up periods. They were divided into the following - 7 months to 2 years (89 joints), 3-5 years (6 joints), 6-10 years (39 joints), and above 11 years (10 joints). Overall, 37.4% of the joints had complete response, 56% had partial response, and 6% of the joints had no response. Conclusion Radiation synovectomy is a noninvasive and effective modality which decreases the bleeding episodes in hemophiliac joints and improves the quality of life remarkably. Copyright © 2020 Indian Journal of Nuclear Medicine.Background Coronary artery calcification (CAC) can be visually estimated on computed tomography (CT) attenuation correction (CTAC) of positron emission tomography (PET). The visual estimation of CAC from CTAC scans performed for PET/CT is comparable to the standard CAC score scan. Myocardial perfusion imaging (MPI) with single-photon emission CT (SPECT) is commonly performed for risk stratification before oncologic surgery. Objective We investigated the value of visual estimation of CAC from CTAC of PET/CT as well as other factors such as coronary artery disease (CAD) risk factors and type of cancer as predictors of MPI ischemia. Methods Retrospectively, we identified 268 patients who underwent PET/CT and MPI for preoperative cardiac evaluation. Visual estimation of CAC was performed and classified into four categories. Results The results of visual CAC were as follows 47.8% - zero CAC, 32.8% - mild CAC, 14.2% - moderate CAC, and 5.2% - severe CAC. The majority of patients (85.8%) had normal MPI, whereas 14.2% were abnormal.