This brings new clinical perspectives on the development of intervention strategies to improve the quality of foot sole cutaneous feedback. It also seems to be a promising approach in the management of patients with balance disorders, with specific chronic pain syndromes, with neurologic diseases or those at risk of falling. PURPOSE to evaluate clinical predictors of positive surgical margins (PSMs) in a large multicenter prospective observational study and to develop a clinic nomogram to predict the likelihood of PSMs after partial nephrectomy (PN). MATERIALS AND METHODS We prospectively evaluated 4308 patients who had surgical treatment for renal tumors between January 2013 and December 2016 at 26 urological Italian Centers (RECORd 2 project). Two multivariable logistic models were evaluated to predict the likelihood of PSMs. Center caseload was dichotomized using a visual assessment adjusted for several predictors of PSMs. A nomogram predicting PSMs was developed. RESULTS Overall, 2076 patients treated with PN were evaluated. pT1a, pT1b, pT2 and pT3a were recorded in 68.7%, 22.6%, 2.1% and 6.6% of the patients, respectively. PSMs were recorded in 342 (16.5%) patients. From a null multivariable model against number of PN/year, 60 PN/year were identified as the best cut-off to define a high-volume centre. At multivariable analysis, clinical stage (cT1a vs. cT2 [OR 1.94]; p = 0.03), volume centre (≤60 PN/year) (OR 2.22; p  less then  0.0001), imperative vs elective indication (OR 2.10; p = 0.04), surgical technique (laparoscopic vs. open [OR 1.62; p = 0.002), lymphovascular invasion (OR 2.27; p = 0.01) and upstaging to pT3a (OR 2.81; p  less then  0.0001) were independent predictors of PSMs. The final nomogram included age, ASA score, Charlson score, clinical tumor stage, surgical indication, surgical approach, surgical technique, PADUA score, clamp procedure and volume centre. CONCLUSIONS PSMs after PN were significantly more likely in patients with lower clinical stage, higher PADUA score, in individuals referred to laparoscopic PN and in those treated at lower volume centers. We used these data to develop a nomogram to predict such risk. Intrahepatic cholangiocarcinoma (iCCA) is the second most common hepatic malignancy and its incidence has been shown to increase significantly during the past decades. Complete surgical resection is currently acknowledged as the only curative treatment option able to provide adequate long-term outcomes. We herein review technical, functional and oncologic limitations for resectability, discuss current surgical aspects as well as highlight the fields in which future research and practice should focus on in order to ameliorate long-term outcomes in patients with iCCA.  https://www.selleckchem.com/  There is a strong relationship between Alzheimer's disease (AD) and sleep problems, and a sleep condition is informative for evaluating the AD status. In the present study, we evaluated subjective sleep problems in AD and mild cognitive impairment (MCI) with self-check questionnaires and objective sleep problems with a convenient home-based portable device, WatchPAT. A total of 63 subjects with normal cognition (NC) (n = 22), MCI (n = 20), and AD (n = 21) were cross-sectionally investigated. AD patients showed a better self-check Pittsburgh sleep quality index (PSQI) score (*p  less then  0.05) than NC and MCI patients. On the other hand, WatchPAT analysis showed a significantly reduced rapid eye movement (REM) sleep (*p  less then  0.05) and increased light sleep in AD patients (*p  less then  0.05) compared with NC subjects, and mildly reduced REM and increased light sleep in MCI subjects. The present study revealed a gap between the subjective self-check sleep questions and the objective WatchPAT analysis in AD patients. Thus, a home-based sleep study with WatchPAT is a useful tool to detect an objective sleep problem in AD and the risk of MCI conversion into AD. The anomalous anatomical arrangement of the cervical spinal nerve roots within the spinal canal can complicate the surgical treatment of several pathologies. This work aimed to reveal intraspinal anatomical anomalies of the extradural and also intradural cervical spinal nerve roots courses. The anatomical study was realised in 43 cadavers with a mean age of 53.7 (32 men and 11 women). After opening the spinal canal and also the dural sac the intradural and extradural anomalies of the cervical spinal nerve roots (bilaterally) were explored and documented. We found completely 49 cases (56.98%) of intraspinal cervical nerve root anomalies. Extradural anomalies were found in 11 cases (12.79%) including atypical spacing, two roots exiting through one neuroforamen, extradural communications, aberrant root. Intradural anomalies observed in 28 cases (32.56%) comprised communications between the dorsal roots and ventral roots separately or together and the multiple communications. Other anomalies (10 cases, 11.63%) included various types of atypical spacing of the roots and their asymmetry. All the results are differentiated according to the plexus type (pre-, postfixed, normotyped). This study describes intraspinal (extradural and intradural) anatomical anomalies of the cervical spinal nerve root courses. Knowledge of these variabilities should help to prevent the failure of several medical procedures. The aim of this study was to evaluate changes in measured volumes using Statistical Parametric Mapping (SPM) 12 caused by contrast changes in magnetic resonance (MR) image. Twenty-one healthy subjects participated in the study. From all subjects, 3D T1-weighted images (T1WIs) were obtained using a 3T scanner. In the first step of creating reference volume data, we used SPM12 to binarize all the segmented data. In the second step, we assigned simulated 3D-T1WI signal intensities to each tissue image and used the following values. The last step was integration of each tissue image to generate 3D-T1WI simulated reference volume data for each participant. To create the reference 3D-T1WIs with various contrasts from the reference volume data, we varied the signal intensity of gray matter from 900 to 600, 700, 1100, 1300, and 1400. The reference 3D-T2WI was acquired using the method used for 3D-T1WIs. Then, six 3D-T1WIs were processed using intrasubject bias-correction processing with SPM12, resulting in six new 3D-T1WIs of nonuniform signal intensities.