Hepatocellular carcinoma represents one of the most aggressive cancers with high recurrence rates. The high recurrence is a major problem in the management of this disease. Cancer stem cells (CSCs) are often regarded as the basis of cancer recurrence. The anti-proliferative therapy kills the proliferating cells but induces mitotic quiescence in CSCs which remain as residual dormant CSCs. Later on, withdrawal of treatment reactivates the residual CSCs from dormancy to produce new cancer cells. The proliferation of these newly formed cancer cells initiates new tumor formation in the liver leading to tumor recurrence. HCC cells evade the immune surveillance via modulating the key immune cells by alpha feto-protein (AFP) secreted from CSCs or hepatic progenitor cells. This AFP mediated immune evasion assists in establishing new tumors by cancer cells in the liver.  https://www.selleckchem.com/Androgen-Receptor.html  In this review, we will summarise the CSC mechanisms of recurrence, mitotic quiescence, dormancy and reactivation of CSCs, metastasis and immune evasion of hepatocellular carcinoma. ©Copyright the Author(s), 2020.The main role of amniotic membrane (AM), or amnion, is to protect the fetus from drying out and create an appropriate environment for its growth. AM is also a suitable candidate for the treatment of various diseases due to its unique characteristics. In recent years, a new line of research has focused on the anticancer properties of amnion and its potential use in cancer treatment. The in vitro and in vivo studies indicate the anti-proliferative and proapoptotic activities, as well as the angioregulatory and immunomodulatory properties of the amniotic membrane. However, the exact mechanism and molecular basis of these anticancer effects of AM are not fully elucidated. This paper presents an overview of the latest findings and knowledge about the anticancer effects of AM and its underlying molecular mechanisms, which is crucial for the application of amnion in cancer therapy. ©Copyright the Author(s), 2020.Urothelial carcinoma is usually characterized by severe symptoms including macroscopic haematuria. We here report the case of a female patient without a history of smoking or urothelial carcinoma, making it, to our knowledge, a unique case and a first case of urothelial carcinoma revealed by brain metastasis. © Ahsaini Mustapha et al.Introduction children pay a heavy price for infection with the hepatitis B virus (HBV). The objective of this work was to determine the prevalence of hepatitis B and describe the associated factors in children at the pediatric department of Donka Hospital. Methods this was a cross-sectional study of a cohort of children in the pediatric department of Donka Hospital. HBsAg was performed by using an immunochromatographic method. The analysis of the data was done with software R. The proportions were compared using the Chi-square test or the Fisher test at the significance level of 5%. A logistic regression model was used to explain the prevalence of hepatitis B. Results one hundred and forty-nine children were recruited between February and July 2017. HBsAg was present in 12 children, i.e. 8.16% (95% CI 4.29-13.82). The average age was 93.32 months (IQR 6-180). Male children were the most affected (n = 11, P less then 0.05), with a sex ratio of 1.01. The majority (51.35%) were on AZT + 3TC + NVP pediatric form and 25% were on AZT + 3TC + NVP adult form and 23.65% on TDF + FTC + EFV. In univariate analysis, ALT, HBsAg positivity, and maternal HBV vaccination status were associated with the prevalence of HBsAg (P less then 0.05). Conclusion the prevalence of co-infection in children and adults is almost identical in our context. Hence the importance of strengthening preventive measures at all levels, especially the vaccination of children and mothers. © Djiba Kaba et al.Introduction the partograph is a pre-printed paper form used in monitoring the progress labor. It was initially introduced by Philpot; and endorsed by the World Health Organization as a simple and accurate instrument for early recognition of complications of labor. Our study was conducted to evaluate the utilization of the partograph and associated factors among obstetric care providers in the Eastern zone of Tigray, Northern Ethiopia 2017. Methods a cross-sectional study was conducted in the Eastern zone of Tigray. Four hundred and fourteen participants were randomly selected from the Eastern zone weredas (districts). Data were collected using a self-administered questionnaire. The data were entered into epi data version 3.5 and exported to SPSS V-20 for analysis. Bivariate and multivariate analysis were done to determine the association between a dependent variable and independent variables at P-value less then 0.05. Results of the 406 obstetric care providers, 83% of them had utilized the partograph to monitor labor. In addition, utilization of the partograph were statistically associated with being female (AOR=2.09, 95%CI= (1.11, 3.93), age group of 20-25 (AOR=0.25, 95%CI= (0.07, 0.88), being a diplomat midwives (AOR=0.01, 95%CI= (0.00, 0.28)) and having qualified from pre-service training (AOR=0.01, 95%CI= (0.02, 0.05)). Conclusion participants' utilization of the partograph was generally good. However, most of them were using it incorrectly. Age, gender, level of educational, year of qualification from pre-service training were the variables that showed association with the utilization of the partograph. The provision of on-the-job training on the partograph is recommended to improve partograph utilization. © Guesh Welu Gebreslassie et al.Adrenal myelolipoma (MLS) is a rare, benign and non-functional neoplasm, composed of adipose tissue and myeloid. We report a rare case of adrenal myelolipoma of a 20-year-old female revealed with chronic abdominal pain. Computed tomography (CT) scan of the abdomen guided diagnosis and surgical resection was performed given symptomatic and bulky mass. Histological examination confirmed the diagnosis. At 18 months after the surgery, the patient had no evidence of recurrence. The diagnosis of MLS is radiological. Therapeutic abstention is the rule for a small, asymptomatic tumor. The surgical removal is indicated when it is bulky (exceeds 7cm), symptomatic or hormonal activity. © Wassim Alaoui Mhammedi et al.