https://www.selleckchem.com/ OBJECTIVE Cd exposure is a non-traditional risk factor of cardiovascular disease and mortality by promoting the development of atherosclerosis. The development of atherosclerosis can be monitored non-invasively by measuring carotid intima-media thickness (CIMT). This study aimed to measure the level of blood Cd and other factors known to be associated with CIMT, measured at the segment of common carotid artery (CCA) and of internal carotid artery (ICA), in young adults from Padang, West Sumatera, Indonesia, and we analyzed whether blood Cd is a predictor of CIMT. RESULTS We recruited 156 subjects. Median blood Cd level was 0.61 μg/L (range 0.01-5.96 μg/L), with no difference in male compared to female subjects (Mann-Whitney U test, p = 0.60). Multiple regression analysis showed that sex is the predictor of CCA IMT (adjusted R2 = 0.219; β = -0.438 [95% CI - 0.662, - 0.214]; p  less then  0.001) and ICA IMT (adjusted R2 = 0.165; β = - 0.529 [95% CI - 0.761, - 0.297]; p  less then  0.001). Blood Cd was not a predictor of CCA IMT (adjusted R2 = 0.219; β = - 0.101 [95% CI - 0.257, 0.055]; p = 0.203) and ICA IMT (adjusted R2 = 0.165; β = - 0.055 [95% CI - 0.217, 0.107]; p = 0.503) in young adults from Padang, Indonesia.BACKGROUND Mesenchymal stem/stromal cells (MSCs) are multipotent cells with a promising application potential in regenerative medicine and immunomodulation. However, MSCs cultured in vitro exhibit functional heterogeneity. The underlying molecular mechanisms that define MSC heterogeneity remain unclear. METHODS We investigated the gene expression profile via single-cell RNA sequencing (scRNA-seq) of human primary Wharton's jelly-derived MSCs (WJMSCs) cultured in vitro from three donors. We also isolated CD142+ and CD142- WJMSCs based on scRNA-seq data and compared their proliferation capacity and "wound healing" potential in vitro. Meanwhile, we analyzed publicly available adipose-derived MSC (ADMSCs) scRNA-seq data and performe