To determine the oncological outcome and pattern of ovarian tumours in patients who underwent surgical management.
 
  The retrospective, descriptive hospital-based study was conducted at Shaukat Khanum Memorial Cancer Hospital, Lahore, Pakistan, and comprised data of all patients who underwent surgical intervention for ovarian cancer between January 2010 and December 2015. Data was retrieved from the hospital database and analysed using SPSS 20.
 
  Of the 236 patients, 203(86%) had undergone open surgery, while 33(14%) had had laparoscopic surgery. Neo-adjuvant chemotherapy was given in 60(25.42%) cases and adjuvant chemotherapy in 102(43.22%). Epithelial ovarian cancer in 201(85.16%) cases was the most common tumour type. Mortality was recorded in 36(15.5%) cases, while 41(19.9%) were lost to follow-up.
 
  Ovarian tumours were found to be difficult to treat and were associated with frequent recurrence.
 Ovarian tumours were found to be difficult to treat and were associated with frequent recurrence.
  To explore the perceptions of doctors holding dual jobs regarding professionalism in public and private healthcare sectors.
 
  The qualitative phenomenological study was conducted from January to June 2016 in a tertiary care teaching hospital affiliated with Sheikh Zayed Medical College, Rahim Yar Khan, Pakistan, and comprised 10 doctors holding dual jobs. Data was collected through video-recorded interviews which were transcribed verbatim and analysed for themes using interpretative phenomenological analysis.
 
  There were 10 doctors in the study. Monetary benefit was the main motive behind holding dual jobs. Contented and internally motivated practitioners with faith in Almighty and a sense of accountability before Him were likely to behave much more professionally, and a virtue-based medical education could play a vital role in this regard.
 
  Overall lack of faith and internal motivation has shifted the focus of sustenance to material resources.
 Overall lack of faith and internal motivation has shifted the focus of sustenance to material resources.
  To assess the association of miR-146a and its target protein RhoA expression levels in breast cancer.
 
  The case-control study was conducted at Riphah International University, Islamabad, Pakistan, from March 2017 to November 2018, and comprised confirmed breast cancer cases and controls who were matched for age and ethnicity. Genotyping and expression profiling of archived samples was performed. Data was analysed using SPSS 22.
 
  Of the 590 subjects, 295(50%) each were cases and controls. Among the cases, there were 195(66%) Punjabis, 59(20%) Pathans and 41(14%) Kashmiris. The corresponding numbers among the controls were 198(67%), 58(19.7%) and 39(13.2%). The association between genotypes of the cases and controls was significant (p<0.05). Strong association was seen in dominant, recessive and allelic models (p=0.05). In Punjabi group the association was (p<0.00) significant, but this association was not significant in Kashmiri and Pathan groups (p>0.05). No association was found with the receptor status and miR-146a polymorphism.
 
  The miR-146a gene polymorphism rs2910164 G/C was found to have increased susceptibility to breast cancer at genotype and allelic levels.
 The miR-146a gene polymorphism rs2910164 G/C was found to have increased susceptibility to breast cancer at genotype and allelic levels.
  To compare the knowledge scores of basic medical subjects in annual versus modular system among undergraduate medical students.
 
  A cross-sectional survey was conducted on 4th year undergraduate medical students of annual and modular system of Liaquat National Medical College, Pakistan. Study was conducted from 30th November 2017 to 1st June 2018 for a total of 6 months. Sample size was calculated to be 82 students. The data was collected using a structured questionnaire. The student's t-test was applied to compare the mean difference of knowledge scores between the two groups.
 
  Students in modular system retained better knowledge of anatomy as compared to annual students. However, the annual system students retained higher knowledge in subjects of community medicine and pharmacology. Mean knowledge score among students for annual system was 12.98 ± 2.92 and semester system was 13.1 ± 3.03. There was no significant difference observed in overall mean knowledge scores between the two groups (p=0.85).
 
  Students in the annual system scored higher in pharmacology and community medicine.  https://www.selleckchem.com/products/ad-5584.html  This highlighted the need to address the issues of time allocation and implementation strategies for the subjects in the new system. There was no difference between overall knowledge scores in each group, hence, it would be inappropriate to conclude that one system is superior to the other.
 Students in the annual system scored higher in pharmacology and community medicine. This highlighted the need to address the issues of time allocation and implementation strategies for the subjects in the new system. There was no difference between overall knowledge scores in each group, hence, it would be inappropriate to conclude that one system is superior to the other.
  To identify the mediating role of self-confidence in family cohesion and depression in adolescents.
 
  The cross-sectional study was conducted at five mainstream government boys and girls schools in Lahore, Pakistan, from March 1 to November 30, 2019, and comprised adolescents aged 12-19 years. Data was collected using Family Cohesion Scale, Self-confidence Scale and Depression Scale for Adolescents. Data was analysed using SPSS 25.
 
  Of the 394 subjects, 214(54%) were boys and 180(46%) were girls. The overall mean age was 14.76±1.39 years. A significant positive association between family cohesion and self-confidence (p<0.001), and a significant negative association of family cohesion (p<0.001) and self-confidence (p<0.01) with depression was found. Self-confidence partially mediated the relationship between family cohesion and depression (p < 0.05).
 
  Early and timely identification of risk factors can prevent serious consequences of depression in adolescents.
 Early and timely identification of risk factors can prevent serious consequences of depression in adolescents.