https://www.selleckchem.com/products/epz-5676.html Since hypervalent twist followed by reductive elimination is a general reaction pattern for hypervalent iodine reagents, mechanistic studies about the hypervalent twist step could provide significant guidance for experiments. Previous studies have shown that there are two types of hypervalent twist models, i.e. apical twist and equatorial twist. We applied both hypervalent twist models to explain the isomerization mechanism of two important electrophilic trifluoromethylating reagents, Togni I and Togni II. Up to now, there are less detailed studies about the different hypervalent twist modes between both reagents. Here, we successfully identified Togni II's isomerization pathway via equatorial twist, and suggested that different hypervalent twist models should be considered to predict the right mechanisms of reactions with hypervalent iodine reagents participating. This study will also be helpful to design new Togni type reagents with higher intrinsic reactivity and stability by avoiding the formation of acyclic by-products.COVID-19, the disease caused by the newly discovered coronavirus-SARS-CoV-2, has created a global health, social, and economic crisis. As of mid-January 2021, there are over 90 million confirmed cases and more than 2 million reported deaths due to COVID-19. Currently, there are very limited therapeutics for the treatment or prevention of COVID-19. For this reason, it is important to find drug targets that will lead to the development of safe and effective therapeutics against the disease. The main protease (Mpro) of the virus is an attractive target for the development of effective antiviral therapeutics because it is required for proteolytic cleavage of viral polyproteins. Furthermore, the Mpro has no human homologues, so drugs designed to bind to this target directly have less risk for off-target effects. Recently, several high-resolution crystallographic structures of the Mpro in complex with