Older age (≥65years), being a breast cancer survivor compared to prostate cancer, and living in a large compared to small metropolitan area were associated with a lower probability of receiving CRC screening. Having hypertension was associated with higher likelihood of being current on colonoscopy screening guidelines among survivors; but diabetes and obesity were not associated with CRC screening.
 
  Low levels of CRC screening utilization were found among breast and prostate cancer survivors in a single center in Southern Maryland. Gender, comorbidities, and residential factors were associated with receipt of CRC screening.
 Low levels of CRC screening utilization were found among breast and prostate cancer survivors in a single center in Southern Maryland. Gender, comorbidities, and residential factors were associated with receipt of CRC screening.Merkel cell carcinoma (MCC) is a rare but aggressive skin cancer with a high risk of returning and spreading. It affects about 2500 new patients every year in the USA. Current effective treatments for advanced MCC include immunotherapy and chemotherapy. Immunotherapy helps a patient's immune system fight against cancer, but only half of MCC patients have long-term benefit. Chemotherapy works initially, but the cancer starts growing again after an average of 90 days. Moreover, chemotherapy can cause severe side-effects. Therefore, we need newer treatments for advanced MCC. Somatostatin analogues (SSAs), a therapy targeted to cancer cells that have somatostatin receptors (SSTRs) on their surface, works well in some cancers. In our study, we tested whether MCC cells have SSTRs on their surface, which would allow SSAs to bind, and whether SSAs fight well against MCC tumours. We first needed to know how often MCC tumours have SSTRs within the tumour cells because SSAs need to bind to SSTRs to work. We checked this by using somatostatin receptor scintigraphy (a special type of radiologic scan) in 40 patients and by pathologic staining (colouring the tumour cells on a biopsy with a dye for better visibility). Thirty-three of 39 (85%) patients had some level of SSTRs in their tumours. We then treated 19 of these patients with SSA, and about 40% of patients benefitted without bad side-effects. Our data supports that targeting SSTRs should be tested further in advanced MCC. Linked Article Akaike et al. Br J Dermatol 2021; 184319-327.The histone acetyltransferase MOF (KAT8) is mainly involved in the acetylation of histone H4 at lysine 16 (H4K16) and some non-histone proteins. The MOF expression level is significantly reduced in many cancers, however the biological function of MOF and its underlying mechanism are still elusive in hepatocellular carcinoma (HCC). Estrogen receptor α (ERα) has been considered as a tumor suppressor in HCC. Here, we demonstrated that MOF expression is significantly reduced in HCC samples, and is positively correlated with that of ERα. MOF interacts with ERα, and participates in acetylation of ERα at K266, K268, K299, thereby inhibiting ERα ubiquitination to maintain the stability of ERα. In addition, MOF participates in the upregulation of ERα-mediated transactivation. Depletion of MOF significantly promotes cell growth, migration, and invasion in HCC cell lines.  https://www.selleckchem.com/products/ziritaxestat.html  Taken together, our results provide new insights to understand the mechanism underlying the modulation function of MOF on ERα action in HCC, suggesting that MOF might be a potential therapeutic target for HCC.
  To present an effective and easily applicable method for tracheoesophageal puncture (TEP) closure by using a localized annular flap instead of bulky and distant flaps.
 
  The medical records of patients who underwent TEP closure surgery with the annular mucosal flap technique between July 2012 and August 2018 were retrospectively reviewed. Fistula size, indication for closure, duration of surgery, radiotherapy status, and surgery results were analyzed.
 
  We have used our technique in nine patients. No postoperative bleeding, wound infection, esophageal stenosis, and tracheostoma stenosis occurred. In all these patients except one, successful closure was achieved. None of the patients had a recurrence of the TEP.
 
  The annular mucosal flap technique for TEP closure is easy and quick to apply. The patient's oral feeding at the sixth hour after procedure without using a nasogastric tube makes the technique preferable as a priority.
 The annular mucosal flap technique for TEP closure is easy and quick to apply. The patient's oral feeding at the sixth hour after procedure without using a nasogastric tube makes the technique preferable as a priority.This study investigated the integrative effects of parents' perceptions of child difficultness and parental emotion dysregulation on emotion-related parenting among a group of Chinese parents of school-age children. One hundred and fifty parent-child dyads (121 biological mothers and 29 biological fathers as primary caregivers; Mage = 39.22 years) from urban Beijing, China participated in the study. Parents reported on their own emotion dysregulation and their children's difficultness, as well as their emotion socialization practices. Children (Mage = 8.54 years; ranged from 6 to 12 years) reported on their parents' use of psychological control strategies. Main and interactive effects were tested using path analysis. Results indicated that parents' perceived child difficultness was negatively associated with supportive reactions to children's expression of negative emotions, and parental emotion dysregulation was positively associated with unsupportive reactions. When parents perceived their children to be difficult and also reported emotion regulation difficulties of their own, they showed the highest levels of psychological control (child reports). These findings suggest differential effects of parent cognition and emotion on supportive and unsupportive reactions to children's negative emotions. Both cognition and emotion play important roles in relation to parents' use of psychological control.
  This study assessed the Streptococcus pneumoniae colonisation rate and susceptibility to antibiotics among preschool children in rural Vietnam.
 
  Nasopharyngeal samples were collected from 546 preschool children aged 6-59months living in 460 households in the rural BaVi District of Hanoi and their main caregivers completed questionnaires. The samples were cultured, and the Streptococcus pneumoniae colonisation rate and antibiotic susceptibility were investigated. Resistance data from this 2014 study were compared with studies in 1999 and 2007, to identify 15-year trends, together with clinical isolates from a national surveillance system of 16 Vietnamese hospital laboratories established in 2013.
 
  We found that 221/546 (40%) of the cultures were positive for Streptococcus pneumoniae. The susceptibility rates were trimethoprim-sulphamethoxazole (5%), erythromycin (8%), ciprofloxacin (12%), benzyl-penicillin (35%), tetracycline (49%), cefotaxime (55%), moxifloxacin (99%) and vancomycin (99%). All the susceptibility rates were lower in 2014 than 1999 and 2007, except tetracycline.