https://www.selleckchem.com/mTOR.html Finally, the optimization design methods for PUT are concluded, and their future perspectives are discussed.The Internet of Things (IoT) is a key and growing technology for many critical real-life applications, where it can be used to improve decision making. The existence of several sources of uncertainty in the IoT infrastructure, however, can lead decision makers into taking inappropriate actions. The present work focuses on proposing a risk-based IoT decision-making framework in order to effectively manage uncertainties in addition to integrating domain knowledge in the decision-making process. A structured literature review of the risks and sources of uncertainty in IoT decision-making systems is the basis for the development of the framework and Human Activity Recognition (HAR) case studies. More specifically, as one of the main targeted challenges, the potential sources of uncertainties in an IoT framework, at different levels of abstraction, are firstly reviewed and then summarized. The modules included in the framework are detailed, with the main focus given to a novel risk-based analytics module, where an ensemble-based data analytic approach, called Calibrated Random Forest (CRF), is proposed to extract useful information while quantifying and managing the uncertainty associated with predictions, by using confidence scores. Its output is subsequently integrated with domain knowledge-based action rules to perform decision making in a cost-sensitive and rational manner. The proposed CRF method is firstly evaluated and demonstrated on a HAR scenario in a Smart Home environment in case study I and is further evaluated and illustrated with a remote health monitoring scenario for a diabetes use case in case study II. The experimental results indicate that using the framework's raw sensor data can be converted into meaningful actions despite several sources of uncertainty. The comparison of the proposed framework to existing