In recent years, sulforaphane (SFN) has been shown to have antitumor effects. To better understand the molecular basis of SFN intervention in estrogen-dependent breast cancer, integrated multi-omics data analysis was used to provide evidence and insights into molecular biology. MCF-7 breast cancer cells were treated with estradiol (E2) or/and SFN. Genome-wide DNA methylation analysis was performed by using microarray platforms. The protein profile was analyzed by TMT labeled HPLC-MS/MS. The metabolic profile was obtained by GC-MS and UPLC-MS methods. Multivariate statistics analyses, such as PCA and hierarchical clustering, were performed. The Gene Ontology (GO) and KEGG analysis were used to perform enrichment analysis of biological processes and pathways. A set of differentially methylated genes and differentially expressed proteins and metabolites were found, which indicated that SFN may reverse the adverse effects induced by E2. Integrated analysis revealed cancer genes that responded to estrogen and other pathways frequently associated with cancer. Co-pathway analysis revealed that the reversal effects of SFN were associated with purine metabolism and glutathione metabolism. The integrated omics analysis outlined a promising blueprint of the relationship of biological molecules in different dimensions, which will be beneficial for understanding the mechanism of anti-breast cancer effects and for new targets of medicines.Oxidative stress induced necroptosis is important in myocardial ischemia/reperfusion injury. Dexmedetomidine (Dex), an α2-adrenoceptor (α2-AR) agonist, has protective effect on oxidative stress induced cell apoptosis, but effects of Dex and Dex-mediated α2-AR activation on oxidant induced necroptosis was unclear. H9C2 cardiomyocytes were pre-treated with or without Dex and α2-AR antagonist yohimbine hydrochloride (YOH) before being exposed to H2O2 to induce oxidative cellular damage. Cell viability and lactate dehydrogenase (LDH) were detected by ELISA kits, protein expressions of Heme Oxygenase 1(HO-1), receptor interacting protein kinase 1 (RIPK1) and receptor interacting protein kinase 3 (RIPK3) were observed by WB, and TUNEL was used to detected cell apoptosis. H2O2 significantly decreased cell viability and increased LDH release and necroptotic and apoptotic cell deaths (all p  0.05). These findings indicated that Dex attenuates H2O2 induced cardiomyocyte necroptotic and apoptotic cell death respectively dependently and independently of α2-AR activation.BACKGROUND Managing a medication regimen is a complex self-care activity that requires a high level of integration and coordination between cognitive and physical skills. This scoping review aims to identify available instruments designed to assess an adult individual's ability to manage a medication regimen independently and to identify reliable and valid tools to be used in clinical practice and research. METHODS Five databases (PubMed/MEDLINE, CINAHL Complete, PsycINFO, Embase, and International Pharmaceutical Abstracts) were searched to identify articles reporting the development of an instrument to assess medication self-management capacity in adults. The process included a broad initial search of the databases, followed by screening of titles and abstracts, and full review of relevant articles. For each instrument identified, characteristics, including validity and reliability assessments, were summarized. RESULTS Sixteen papers were identified that reviewed or described the development and/or validation of 26 instruments designed to assess medication self-management capacity.  https://www.selleckchem.com/products/pifithrin-alpha.html  Most instruments were designed to identify cognitive and physical barriers to successful medication management, but there was inconsistency across instruments in the specific skills assessed and the assessment method used. Most instruments were validated by testing at least one related construct, such as cognitive function, activities of daily living or instrumental activities of daily living performance, or medication adherence. CONCLUSION Development of standardized instruments to quantify medication self-management capacity is still growing. The choice of instrument for use in a specific clinical or research setting will depend on the purpose for making the assessment and the population that it will be applied to. Results of this review can assist in selecting an appropriate instrument or guiding the development of new instruments for assessment of medication self-management capacity for specific clinical or research purposes.Battery electric vehicles (BEV) have become the most effective and environmentally friendly means to replace internal combustion vehicles. However, given the fact that BEV are a relatively new product category, and the majority of car users have little experience of using BEV, consumers often have a misconception about BEV, and thus tend to avoid purchasing an electric vehicle. This paper aims to explore the role of customer experience and demonstrate how this experience affects the adoption willingness of BEV. Based on driving experience and the theory of planned behavior, the authors constructed a framework of influencing factors for electric vehicle adoption willingness with the incorporation of consumer experience as the antecedents of adoption willingness. Using sample data from Jiangsu province, China, our empirical analysis shows that the mean values of the subjective norm, perceived behavioral control, attitudes, and adoption willingness of experienced consumers are significantly higher than those of inexperienced consumers. Further, the adoption willingness is positively influenced by experience through direct and indirect paths, which confirms the significant mediating effects of subjective norm, perceived behavioral control, and attitudes (battery life, cruising range, low noise, and low emission).Artificial reservoirs play an important role in intercepting organic carbon (OC), which affects the carbon cycle of inland waters. However, limited by the methods of field observations, studies on the potential carbon sink of sediment in reservoirs are not accurate enough. In this study, we investigated OC accumulation in the Wujiangdu Reservoir (WJDR), a canyon reservoir located in a karst area of Southwest China, by coupling seismic survey data with physicochemical data of sediment cores. The results showed that irregular underwater topography resulted in spatial heterogeneity of the sediment deposition. The mean OC accumulation rate in the WJDR was 579.2 g C m-2 year-1, and the OC accumulation flux of the WJDR was 1.4 × 1010 g C year-1. δ13C values coupled with a mixing model indicated that the autochthonous OC ranged from 14.2 to 97.0% of the total OC in the sediment, with an average of 48.4%. The significantly positive relationship between autochthonous OC and TN indicated that the autochthonous OC generated in the reservoir was associated with nutrient input.