Bangladesh is now experiencing the COVID-19 outbreak; however, there has been minimal focus on mental health over physical health problems during this pandemic in Bangladesh. The present study was conducted using self-rated scales on a sample of 500 Bangladeshi people to address this gap. Results suggested two-fifths of the participants had depression and anxiety symptoms, and one-third were highly worried and felt stressed. Females, students, unmarried, and 18-30-year-olds were in more vulnerable positions in terms of their mental health. These findings would be helpful to assess and formulate psychological interventions to improve the mental health of vulnerable groups.This is a cross-sectional study based on an open web survey with the primary objective to assess associations between the use of apps for seeking sex partners and vulnerabilities related to human immunodeficiency virus (HIV) acquisition among men who have sex with men (MSM) in Brazil. Participants were recruited to the study through ads posted in social media such as Twitter, Facebook, and WhatsApp. Consenting respondents completed a questionnaire on demographics, history of sexually transmitted infections (STIs), and risk behaviors and perceptions, including calculation of the Risk Behavior Score for HIV infection proposed by Rocha et al. Among the 859 participants, 714 (83.1%) reported they used apps for seeking sex partners. Use of apps for seeking sex partners was associated with high-risk behavior for HIV infection, self-reported syphilis, self-perception of HIV risk, and use of marijuana. The use of apps for seeking sex partners has rapidly become the norm for MSM in Brazil. The associations with STIs and risk behaviors should be seen as an opening to improve public health, presenting opportunities to promote knowledge, safer sex practices, and referral to HIV/STI screening and prevention interventions.National guidelines give advice on topics which should be covered when counselling patients with a new diagnosis of genital herpes (HSV) with the aim of reducing transmissions. This three-site UK audit of documentation of counselling for patients with a new diagnosis of genital herpes reviewed the records of 284 patients. Documentation in all areas of counselling was limited and this may result in adverse medico-legal consequences for patients and clinicians.Researchers examined psychometric characteristics of the Safe Dates-Physical Violence Victimization scale in 97 Jordanian college women.  https://www.selleckchem.com/products/nicotinamide-riboside-chloride.html  Reliability coefficient and Principal Components Analysis were used. Construct validity was examined using independent samples t-test. Cronbach's alpha of 0.80 was yielded. Two dimensions (injury-causing tactics and threatening tactics) were identified. Using construct validity analysis, researchers indicated significant differences in the mean depression, anxiety, stress, and childhood victimization scores among women reporting physical violence, compared to their counterparts. College women possess psychological stressors due to academic and social responsibilities. Such stressors influence their decision to leave the partner which adversely impacts their psychological health.Aim Sperm cryopreservation (SCP) should be offered to every adolescent before gonadotoxic treatment, but experience in this age range is still relatively limited. The goal of this study is to assess how to optimize this procedure. Methods and Patients One hundred thirty-three patients between 12 and 20 years old, who underwent SCP between 1980 and 2017, were included. Baseline data (age, indication for SCP, and semen parameters at freezing) and follow-up data (outcome of sperm straws and follow-up of sperm quality) were collected and analyzed. Results SCP is feasible from the age of 12. Semen assessment parameters at this age were close to parameters of adults. However, we observed quantitative impairments in testicular tumors and qualitative impairments in leukemia and bone marrow failure. Four patients (3%) used their cryopreserved semen for medically assisted reproduction, 15 patients died (11.3%), 18 asked for destruction of their straws (13.5%), and nine samples were destroyed because of lack of news (6.8%). Very few patients underwent a sperm analysis after treatment. Conclusions SCP is an efficient, still underused, procedure for adolescents and young adults. Cryopreserved sperm is rarely used and rarely destroyed, but studies with a longer follow-up are needed to better assess these observations. Follow-up with a specialist of reproductive medicine is valuable for better information of the patient.
  L. (Capparaceae) is grown worldwide. Caper has been used in traditional medicine to treat various diseases including rheumatism, kidney, liver, stomach, as well as headache and toothache.
 
  To isolate and elucidate of the secondary metabolites of the 
  extracts which are responsible for their anti-inflammatory activities.
 
  Buds, fruits, flowers, leaves and stems of 
  Desf. was dried, cut to pieces, then ground separately. From their dichloromethane/hexane (11) extracts, eight compounds were isolated and their structures were elucidated by NMR, mass spectroscopic techniques. The effects of compounds on the expression of inflammatory cytokines in SH-SY5Y cell lines were examined by qRT-PCR ranging from 4 to 96 µM. Cell viability was expressed as a percentage of the control, untreated cells.
 
  This is a first report on isolation of triterpenoids and steroids from 
  with anti-inflammatory activity. One new triterpenoid ester olean-12-en-3β,28-diol, 3β-pentacosanoate (
  ) and two new natural steroids 5α,6α-epoxycholestan-3β-ol (
  ) and 5β,6β-epoxycholestan-3β-ol (
  ) were elucidated besides known compounds; oleanolic acid (
  ), ursolic acid (
  ), β-sitosterol (
  ), stigmast-5,22-dien-3β-myristate (
  ) and bismethyl-octylphthalate (
  ). mRNA expression levels as EC
  of all the tested seven genes were decreased, particularly CXCL9 (19.36-fold), CXCL10 (8.14-fold), and TNF (18.69) by the treatment of 26 µM of compound 
  on SH-SY5Y cells.
 
  Triterpenoids and steroids isolated from 
  were found to be moderate-strong anti-inflammatory compounds. Particularly, compounds 
  and 
  were found to be promising therapeutic agents in the treatment of inflammatory and autoimmune diseases.
 Triterpenoids and steroids isolated from C. ovata were found to be moderate-strong anti-inflammatory compounds. Particularly, compounds 1 and 3 were found to be promising therapeutic agents in the treatment of inflammatory and autoimmune diseases.