Periprosthetic joint infection is one of the devastating complications after primary total knee arthroplasty, which increases the financial burden on patients and affects their quality of life as well. The financial burden of periprosthetic joint infection after joint replacement in developed countries is well known. There is a need to evaluate the economic burden in developing countries such as Pakistan.
 
  This is a single-center, retrospective, case-control study conducted at the Department of Orthopedic Surgery, Liaquat National Hospital Karachi. Cases of primary total knee arthroplasty performed during this study were divided into 2 groups uneventful primary total knee arthroplasty and periprosthetic joint infection treated with 2-stage revision. To calculate the final cost, we divided the total hospital cost into the hospital stay cost and operating room cost.
 
  During study period, 32 patients were diagnosed with periprosthetic joint infection. The total cost of revision surgery for periprosthetic joint infection considering 2 hospitalizations was 1,780,222 ± 313,686 Pakistani rupee (PKR). The total cost of uneventful arthroplasty was 390,172 ± 51,460 PKR. We observed significant difference with respect to economic details between the 2 groups.
 
  Management of periprosthetic joint infection was 4.5 times more expensive than uneventful primary total knee arthroplasty. Measures should be undertaken to reduce the prevalence of periprosthetic joint infection, thereby reducing patients' economic burden.
 Management of periprosthetic joint infection was 4.5 times more expensive than uneventful primary total knee arthroplasty. Measures should be undertaken to reduce the prevalence of periprosthetic joint infection, thereby reducing patients' economic burden.
  The use of hinged designs is usually reserved for severe deformities or instability in contemporary total knee arthroplasty (TKA). Results have been mixed with some authors reporting relatively high incidences of complications. The aim of this study is to present the results of primary TKA performed with a hinged prosthesis with a minimum 10-year follow-up. We also examined the factors that influence survivorship of this prosthesis.
 
  A total of 238 primary TKA procedures were performed using hinged prostheses. Indications included osteoarthritis, rheumatoid arthritis, posttraumatic deformity, and arthritis. Clinical outcomes were assessed using the Hospital for Special Surgery score. Radiologic assessment was performed at each follow-up. Survivorship was calculated based on the Kaplan-Meier method. All complications were documented.
 
  Mean follow-up was 13.5 years (standard deviation [SD], 3.4). Mean flexion at final review was 118° (SD, 20°). Fifty-four percent and 20% reported excellent and good functional scores, respectively. Survivorship was 94% at 13.5 years in patients over 60 years of age and 77% in patients less than 60 years of age.  https://www.selleckchem.com/products/h-1152-dihydrochloride.html  Survivorship in patients with preoperative varus deformity was 96% and that in valgus knees was 79%.
 
  The results of this study suggest that when rotating hinges are used for primary TKA, the best results are achieved in patients over 60 years old. The indications for this design in the setting of primary TKA include significant deformities, severe bone loss, and ligamentous laxity.
 The results of this study suggest that when rotating hinges are used for primary TKA, the best results are achieved in patients over 60 years old. The indications for this design in the setting of primary TKA include significant deformities, severe bone loss, and ligamentous laxity.
  Precise assessment of preoperative mental health and psychological determinants may be useful in identifying patients at risk for poor postoperative outcomes of total knee arthroplasty (TKA). The aim of this study was to investigate the influence of psychological status and physical and mental health on the outcome of patients undergoing TKA.
 
  Fifty-two patients undergoing unilateral TKA were assessed preoperatively with Oxford Happiness Inventory, Eysenck Personality Inventory, 12-item short form health survey (SF-12), and Knee Injury and Osteoarthritis Outcome Score (KOOS) for evaluating depression, personality traits, physical and mental health, and function, respectively. At 1 year after surgery, health-related quality of life (HRQL) and function were assessed using the SF-12 and KOOS.
 
  HRQL and function of all personality traits increased significantly after TKA, without significant difference among them. Extroversion and neuroticism did not have significant correlation with subjective well-being, HRfecting the physical, mental, and functional outcome was depression.
  The constrained insert with non-stemmed tibial and femoral components can be used in the modern total knee arthroplasty (TKA) when soft-tissue balance and adequate stability from a posterior-stabilized (PS) insert cannot be achieved. This study aimed to identify the prevalence and predictive factors associated with the constrained insert use during primary TKA for varus deformity.
 
  From August 2016 to March 2019, 554 primary TKAs were consecutively performed by one surgeon. The choice of using a conventional PS polyethylene insert versus a constrained insert was made by the surgeon, depending on the stability detected after an attempt to balance the soft tissue. The decision to convert to a constrained liner was made if the ligament could not be balanced, if flexion-extension gaps were mismatched, or if the varus-valgus opening was 3 mm or more when varus and valgus stress tests at 0° were applied. We retrospectively investigated the preoperative, intraoperative, and postoperative factors associated with te of soft tissue through the superficial medial collateral ligament were associated with the use of a constrained articulation. The findings from this study will help surgeons to improve efficiency of surgical sequence planning and provide counseling to patients regarding the associated cost.
  19.8° and severe release of soft tissue through the superficial medial collateral ligament were associated with the use of a constrained articulation. The findings from this study will help surgeons to improve efficiency of surgical sequence planning and provide counseling to patients regarding the associated cost.