The ultimate goal of gene expression regulation is on the protein level. However, because the amounts of mRNAs and proteins are controlled by their synthesis and degradation rates, the cellular amount of a given protein can be attained by following different strategies. By studying omics data for six expression variables (mRNA and protein amounts, plus their synthesis and decay rates), we previously demonstrated the existence of common expression strategies (CESs) for functionally related genes in the yeast Saccharomyces cerevisiae. Here we extend that study to two other eukaryotes the yeast Schizosaccharomyces pombe and cultured human HeLa cells. We also use genomic data from the model prokaryote Escherichia coli as an external reference. We show that six-variable profiles (6VPs) can be constructed for every gene and that these 6VPs are similar for genes with similar functions in all the studied organisms. The differences in 6VPs between organisms can be used to establish their phylogenetic relationships. The analysis of the correlations among the six variables supports the hypothesis that most gene expression control occurs in actively growing organisms at the transcription rate level, and that translation plays a minor role. We propose that living organisms use CESs for the genes acting on the same physiological pathways, especially for those belonging to stable macromolecular complexes, but CESs have been modeled by evolution to adapt to the specific life circumstances of each organism.The increasing knowledge of molecular drivers of tumorigenesis has fueled targeted cancer therapies based on specific inhibitors. Beyond "classic" oncogene inhibitors, epigenetic therapy is an emerging field. Epigenetic alterations can occur at any time during cancer progression, altering the structure of the chromatin, the accessibility for transcription factors and thus the transcription of genes. They rely on post-translational histone modifications, particularly the acetylation of histone lysine residues, and are determined by the inverse action of histone acetyltransferases (HATs) and histone deacetylases (HDACs). Importantly, HDACs are often aberrantly overexpressed, predominantly leading to the transcriptional repression of tumor suppressor genes. Thus, histone deacetylase inhibitors (HDACis) are powerful drugs, with some already approved for certain hematological cancers. Albeit HDACis show activity in solid tumors as well, further refinement and the development of novel drugs are needed. This review describes the capability of HDACis to influence various pathways and, based on this knowledge, gives a comprehensive overview of various preclinical and clinical studies on solid tumors. A particular focus is placed on strategies for achieving higher efficacy by combination therapies, including phosphoinositide 3-kinase (PI3K)-EGFR inhibitors and hormone- or immunotherapy. This also includes new bifunctional inhibitors as well as novel approaches for HDAC degradation via PROteolysis-TArgeting Chimeras (PROTACs).Piezoelectric ceramics are inexpensive functional materials which are widely used in sonar detection, home appliances, meteorological detection, telemetry and environmental protection and other applications. Sensors fabricated from these materials are compact and have fast response characteristics. Their underlying functional methodology is based on the direct piezoelectric effect whereby very small mechanical vibration signals are converted into electrical signals. Piezoelectric resonators are based on the reverse piezoelectric effect and they are widely used for the control of precision instruments and precision machinery, microelectronic components, bioengineering devices and other in applications requiring components to provide precision control of the relevant functional mechanism. In this paper, the structural evolution and design mechanism of sandwich resonators based on piezoelectric materials are reviewed, and the advantages and disadvantages of different structures are compared and analyzed. The goal is to provide a comprehensive reference for the selection, application and promotion of piezoelectric resonators and for future structural innovation and mechanism research relevant to sandwich resonators.Earth observation satellites have been capturing a variety of data about our planet for several decades, making many environmental applications possible such as change detection. Recently, deep learning methods have been proposed for urban change detection. However, there has been limited work done on the application of such methods to the annotation of unlabeled images in the case of change detection in forests. This annotation task consists of predicting semantic labels for a given image of a forested area where change has been detected. Currently proposed methods typically do not provide other semantic information beyond the change that is detected. To address these limitations we first demonstrate that deep learning methods can be effectively used to detect changes in a forested area with a pair of pre and post-change satellite images.  https://www.selleckchem.com/products/Temsirolimus.html  We show that by using visual semantic embeddings we can automatically annotate the change images with labels extracted from scientific documents related to the study area. We investigated the effect of different corpora and found that best performances in the annotation prediction task are reached with a corpus that is related to the type of change of interest and is of medium size (over ten thousand documents).Plasmodium parasites' invasion of their target cells is a complex, multi-step process involving many protein-protein interactions. Little is known about how complex the interaction with target cells is in Plasmodium vivax and few surface molecules related to reticulocytes' adhesion have been described to date. Natural selection, functional and structural analysis were carried out on the previously described vaccine candidate P. vivax merozoite surface protein 10 (PvMSP10) for evaluating its role during initial contact with target cells. It has been shown here that the recombinant carboxyl terminal region (rPvMSP10-C) bound to adult human reticulocytes but not to normocytes, as validated by two different protein-cell interaction assays. Particularly interesting was the fact that two 20-residue-long regions (388DKEECRCRANYMPDDSVDYF407 and 415KDCSKENGNCDVNAECSIDK434) were able to inhibit rPvMSP10-C binding to reticulocytes and rosette formation using enriched target cells. These peptides were derived from PvMSP10 epidermal growth factor (EGF)-like domains (precisely, from a well-defined electrostatic zone) and consisted of regions having the potential of being B- or T-cell epitopes.