Electrochemical CO2 reduction over Cu could provide value-added multicarbon hydrocarbons and alcohols. Despite recent breakthroughs, it remains a significant challenge to design a catalytic system with high product selectivity. Here we demonstrate that a high selectivity of ethylene (55%) and C2+ products (77%) could be achieved by a highly modular tricomponent copolymer modified Cu electrode, rivaling the best performance using other modified polycrystalline Cu foil catalysts. Such a copolymer can be conveniently prepared by a ring-opening metathesis polymerization, thereby offering a new degree of freedom for tuning the selectivity. Control experiments indicate all three components are essential for the selectivity enhancement. A surface characterization showed that the incorporation of a phenylpyridinium component increased the film robustness against delamination. It was also shown that its superior performance is not due to a morphology change of the Cu underneath. Molecular dynamics (MD) simulations indicate that a combination of increased local CO2 concentration, increased porosity for gas diffusion, and the local electric field effect together contribute to the increased ethylene and C2+ product selectivity.Here, we report the synthesis of spherical bimetal ZnCo-MOF materials by a hydrothermal rotacrystallization method and their catalytic activity on the air epoxidation of mixed biolefins enhanced by microwaves. The structural and chemical properties of the ZnCo-MOF materials were fully characterized by XRD, IR, SEM, TG, XPS, and NH3-TPD. The morphology of the material exhibited a three-dimensional spherical structure. From an NH3-TPD test of the ZnCo-MOF catalyst, it could be concluded that the Zn0.1Co1-MOF-H-150 rpm material had the highest acidic content and the strongest acidity among the catalysts synthesized by different methods, which gave the best performance in the epoxidation of mixed biolefins. The air epoxidation reaction was carried out under atmospheric pressure and microwave conditions, in the absence of any initiator or coreducing agent. Moreover, the Zn0.1Co1-MOF catalyst could be recycled six times without reducing the catalytic activity significantly, which showed the stability of spherical catalyst material under microwaves.In living systems, subcellular organelles mutually cooperate and closely contact to form organelle interaction networks. Thus, the simultaneous and discriminative visualization of different organelles is extremely valuable for elucidating their distribution and interplay. However, such meaningful investigations remain a great challenge due to the lack of advanced single fluorescent probes (SF-probes) capable of simultaneous and two-color imaging of two targets. Herein, for the first time, we present two excited-state intramolecular proton transfer (ESIPT) based SF-probes (PPC and EPC) for simultaneous two-color fluorescence imaging of lipid droplets (LDs) and the endoplasmic reticulum (ER) under single-wavelength excitation. Due to the strong electron-donating ability of the side substituents, the fluorescence spectra and colors of these ESIPT probes are highly sensitive to the nuance of water contents between LDs and ER, leading to orange and green fluorescence in LDs and ER, respectively, in the Lambda imaging mode. Using the probe PPC or EPC, the morphology, size, and distribution of LDs and ER have been investigated in live cells and tissues.  https://www.selleckchem.com/products/almorexant-hcl.html  With the aid of in situ and real-time fluorescence imaging in Lambda mode, we observed the generation of newborn LDs near the ER regions and their close apposition and shared identical fluorescence colors, probably providing a valuable proof for the mainstream hypothesis that LDs originate from the ER. The remarkable imaging performances render these SF-probes as powerful tools to decipher LD-ER related biological processes.The development of oxygen evolution reaction (OER) catalysts with high activity and high stability through convenient and economical methods is greatly important for the promotion of hydrogen energy based on electrolysis technology. Herein, by using an unconventional high electrodeposition potential, novel petal-like clusters constructed by cross-linking ultrathin nickel hydroxide nanosheets were controllably synthesized on nickel foam (or copper foam or carbon cloth) and the effect of electrodeposition conditions on their OER performance was carefully explored. Due to the abundant catalytically active sites, promoting electron conduction/mass transmission from the specific micro-nano structure, as well as the ultrasmall thickness of ∼3.0 nm, the optimized α-Ni(OH)2/NF self-supporting electrode exhibits excellent electrocatalytic performance for OER, merely requiring low overpotentials of 192 and 240 mV to yield current densities of 10 and 100 mA cm-2 in 1.0 M KOH, respectively, which surpassed those of all of the reported nickel hydroxide/oxides and the benchmark RuO2. Moreover, α-Ni(OH)2/NF can drive the high-current density (500-1000 mA cm-2) OER at low overpotentials, meeting the requirements of potential industrial applications.Structurally unprecedented antibacterial alkaloids containing multiple electron-rich pyrrole units have recently been isolated from Curvularia sp. and Bipolaris maydis fungi. This article documents the evolution of a synthetic program aimed at accessing the flagship metabolites curvulamine and curindolizine which are presumably a dimer and trimer of a C10N biosynthetic building block, respectively. Starting with curvulamine, we detail several strategies to merge two simple, bioinspired fragments, which while ultimately unsuccessful, led us toward a pyrroloazepinone building block-based strategy and an improved synthesis of this 10π-aromatic heterocycle. A two-step annulation process was then designed to forge a conserved tetracyclic bis-pyrrole architecture and advanced into a variety of late-stage intermediates; unfortunately, however, a failed decarboxylation thwarted the total synthesis of curvulamine. By tailoring our annulation precursors, success was ultimately found through the use of a cyanohydrin nucleophile which enabled a 10-step total synthesis of curvulamine.