https://www.selleckchem.com/products/Sunitinib-Malate-(Sutent).html Nanomaterials often surprise us with unexpected phenomena. Here, we report a discovery of the anti-twinning deformation, previously thought impossible, in nanoscale body-centered cubic (BCC) tungsten crystals. By conducting in situ transmission electron microscopy nanomechanical testing, we observed the nucleation and growth of anti-twins in tungsten nanowires with diameters less than about 20 nm. During anti-twinning, a shear displacement of 1/3〈111〉 occurs on every successive 112 plane, in contrast to an opposite shear displacement of 1 / 6 〈 1 ¯ 1 ¯ 1 ¯ 〉 by ordinary twinning. This asymmetry in the atomic-scale shear pathway leads to a much higher resistance to anti-twinning than ordinary twinning. However, anti-twinning can become active in nanosized BCC crystals under ultrahigh stresses, due to the limited number of plastic shear carriers in small crystal volumes. Our finding of the anti-twinning phenomenon has implications for harnessing unconventional deformation mechanisms to achieve high mechanical preformation by nanomaterials.In the equatorial regions on Earth today, the seasonal cycle of the monthly mean surface air temperature is 30°C at various continental locations if the oceans are completely frozen over, as would have been the case for a snowball Earth, or could reach ~20°C if the oceans are not completely frozen over, as would have been the case for a waterbelt Earth. These values are obtained at the maximum eccentricity of the Earth orbit, i.e., 0.0679, and will be approximately 10°C smaller if the present-day eccentricity is used. For these seasonal cycles, theoretical calculations show that the deep sand wedges form readily in a snowball Earth while hardly form in a waterbelt Earth.The ATM (ataxia-telangiectasia mutated) kinase is rapidly activated following DNA damage and phosphorylates its downstream targets to launch DDR signaling. Recently, we and others showed that UFM1 sig