The PEC immunosensor based on a rGO honeycomb structure exhibited a linear detection range of 0.05-100 ng/mL with a detection limit of 0.05 ng/mL. The excellent detection performance of the graphene PEC biosensor provides an opportunity for the early diagnosis of primary liver cancer.Nanogels have potential for encapsulating cancer therapeutics, yet their susceptibility to physiological degradation and lack of cellular specificity hinder their use as effective oral delivery vehicles. Herein, we engineered novel albumin-core with folic acid functionalized hyperbranched amylopectin shell-type nanogels, prepared through a two-step reaction and loaded with curcumin while the proteinaceous core was undergoing thermal gelation. The nanogels had a mean hydrodynamic diameter of ca. 90 nm and ζ-potential of ca. -24 mV. Encapsulation of curcumin within the nanogels was restored, up to ca. 0.05 mg mL-1, beyond which, a gradual increase in size and a decrease in ζ-potential was observed.  https://www.selleckchem.com/products/ABT-263.html  The core-shell structures were resilient to in vitro physiological oral-gastrointestinal digestion owing to a liquid crystalline B- and V-type polymorphism in the polysaccharide shell, the latter being driven by the shell functionalization with folic acid. Additionally, these biocompatible nanogels restored stability of the encapsulated curcumin and exhibited augmented cellular uptake and retention specifically in folate receptor-positive HT29 human colon adenocarcinoma cells, inducing early-stage apoptosis. Novel insights from this study represent a promising platform for rational designing of future oral delivery systems that can surmount physiological barriers for delivering cancer therapeutics to colon cancer cells with improved stability and specificity.Magnetic Fe3O4 nanoparticles were coated by polyethyleneimine (PEI), and then Fe3O4@PEI was further modified with MoS2 by the hydrothermal method to fabricate 3D flower-like structured magnetic polyethyleneimine@MoS2 (MP@MoS2) composites, and the composites were served as efficient adsorbents to capture Cr(VI) and Pb(II) from aqueous solution. The effects of temperature, pH, shaking time and environmental conditions on adsorption performance of MP@MoS2 towards Cr(VI) and Pb(II) have been conducted by batch adsorption experiments. The prepared MP@MoS2 exhibited high adsorption capacities (192.30 mg/g for Cr(VI) at pH 3.0 and 256.41 mg/g for Pb(II) at pH 6.0) and the adsorption equilibrium could be achieved in a short time. Moreover, MP@MoS2 composites with high saturation magnetization could be simply separated under an external magnet. Combined experiments and spectral analysis, the underlying adsorption mechanism for Cr(VI) on MP@MoS2 was mainly attributed to the reduction of Cr(VI) to Cr(III), and the removal of Pb(II) was due to the complexation with sulfur groups and amino-groups. Consequently, the prepared 3D flower-like structured MP@MoS2 has a great potential for the practical application in removing Cr(VI) and Pb(II) from the aquatic environment.The photocatalytic behavior of the graphene oxide (GO) modified Fe(III)/peroxymonosulfate (Fe/PMS) system for bisphenol A (BPA) degradation was investigated. With the addition of GO, a dramatic enhancement of BPA degradation was obtained at pH 3.0 under visible light irradiation. According to ESR analysis and quenching tests, both SO4- and OH are responsible for BPA degradation. The characterization analysis demonstrates that Fe(III) can chelate with the oxygenic functional groups on the surface of GO forming a stable GO-Fe(III) complex. The detections of different kinds of Fe species reveal that Fe(III) can be reduced to Fe(II) by GO via intramolecular electron transfer in the GO-Fe(III) complex, and visible light could enhance this process. The Fe(III)/Fe(II) cycle not only occurs on the surface of GO, but also in aqueous solution via homogeneous reactions. In addition, the degradation pathway of BPA was proposed based on the identification of the intermediates using GC-MS and LC-MS techniques.Currently, aqueous zinc-ion batteries are receiving extraordinary attention because of their cheap price, superior energy density and great security. However, the inferior specific capacity and low rate capability significantly hamper their further widespread application. Herein, a novel egg waffle-like architecture consisting of double-shell ZnMn2O4 hollow microspheres embedded in 2D carbon networks (ZnMn2O4@C) is designed and employed as a cathode material for aqueous zinc-ion batteries. Specifically, the ZnMn2O4@C electrode displays a capacity of 481 mAh g-1 at 0.2 A g-1 after 110 cycles with excellent cycling stability. The superior cycling stability of the ZnMn2O4@C electrode is ascribed to the synergistic effect of the double-shell ZnMn2O4 hollow microspheres, which offer sufficient space to withstand volume expansion during Zn2+ intercalation/deintercalation process, as well as the 2D continuous conductive and interconnected carbon network, which facilitates rapid electronic transmission and guarantees good structural mechanical stability. This study offers a fascinating cathode material and extends the available choices for manganate based-materials in rechargeable aqueous zinc-ion batteries.A softer natural Pickering nanostabilizer, S-ovalbumin (S-OVA) was reported in this work, based on our previous researches about soft globular protein nanoparticles. Compared with native OVA, S-OVA has higher surface hydrophobicity, greater conformational flexibility and thinner tightly-bond water layer, which make it be unfolded more highly at the oil-water interface. However, S-OVA also possesses higher zeta-potential and thicker closely-surrounding water layer, offering it stronger electrostatic repulsion and steric hindrance between molecules and increased intramolecular cohesion. The improvements guarantee S-OVA undisintegrated particle structure and independent state on the interface and high refolding off the interface. The more flexible interior and firmer exterior together endow a higher softness to S-OVA. The HIPPE gels solely stabilized by S-OVA were fabricated using one-step shearing. These HIPPE gels own steady network structure mainly supported by bridging flocculation, strong self-supporting ability and moldability.