Heavy metals are seriously hazardous contaminants and drinking water has been identified as an important route of human exposure to them. Herein, to efficiently and selectively remove trace heavy metal ions, a facile method was reported to achieve the slow polymerization of dopamine in the cages of MIL-100 (Fe) via ultrasonic treatment followed by the hydrolysis of the urea. X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR), Brunner-Emmet-Teller (BET) and pore size distribution determination confirmed the formation of the polydopamine (PDA) and binding with the unsaturated Fe3+ site in MIL-100 (Fe) pores. The composite not only retained pore structure of MOFs but also contained abundant reactive functional groups. When initial lead concentration was 150 ppb and 20 ppm calcium coexisted at pH of 6.5 ± 0.25, the effluent lead concentration met the safe drinking water standard in several tens of seconds, and decreased to 1.13 ppb in 10 min. The adsorption rate reached 99.35%. The synthetic strategy effectively overcomes mass transfer resistance of trace heavy metal ions and provides a facile approach to prepare adsorption materials for efficient and selective removal of trace heavy metal ions from drinking water.The huge production and application of bisphenol A (BPA) and graphene oxide (GO) inevitably lead to their co-presence in aquatic ecosystems, which might cause joint toxic effects to aquatic organisms. Herein, zebrafish larvae at 3 d post fertilization (dpf) were exposed to BPA, GO, and their mixtures until 7 dpf. GO was ingested and localized in the gut. 5000 μg/L BPA alone induced distinct ultrastructure damage, which was alleviated by GO, indicating that GO reduced the developmental toxicity of BPA. The levels of endocrine-related genes and steroid hormones were all modulated to the greatest extent by 500 μg/L BPA, suggesting that BPA exhibited a remarkable endocrine disruption effect. However, the responses of some of these genes were recovered by GO, indicating that GO also alleviated the BPA-induced endocrine disruption. The mRNA levels of five genes in the extracellular matrix-receptor interaction pathway, two in the oxidative phosphorylation pathway, 18 in the metabolic pathways, and five in the peroxisome proliferator-activated receptor signaling pathway were distinctly altered by 5000 μg/L BPA, but most of them were recovered in the presence of GO. GO might relieve the BPA-induced developmental toxicity and endocrine disruption by recovering the genes related to the corresponding pathways.This study aims to address organic micropollutants in secondary effluents from municipal wastewater treatment plants (WWTPs) by first identification of micropollutants in different treatment units, and second by evaluating an advanced treatment process for removals of micropollutants. In secondary effluents, 28 types of pharmaceutical and personal care products (PPCPs), 5 types of endocrine disrupting chemicals (EDCs) and 3 types of odorous compounds are detected with total concentrations of 513 ± 57.8 ng/L, 991 ± 36.5 ng/L, 553 ± 48.3 ng/L, respectively. An integrated process consisting of in-situ ozonation, ceramic membrane filtration (CMF) and biological active carbon (BAC) filtration is investigated in a pilot scale (1000 m3/d) for removal of micropollutants in secondary effluents. The total removal efficiencies of PPCPs, EDCs and odorous compounds are 98.5%, 95.4%, and 91.1%, respectively. Removal mechanisms of emerging organic contaminants (EOCs) and odorous compounds are discussed based on their physicochemical properties. The remarkable removal efficiencies of micropollutants by the pilot system is attributed to synergistic effects of combining ozonation, ceramic membrane filtration and BAC filtration. This study provides a cost-effective and robust technology with the capability of treating secondary effluents for reuse applications.Enhanced UV-B radiation can lead to a variety of stress responses, including effects on cell cycle regulation and mitosis. Aurora kinases are part of the serine/threonine kinase family and play important roles in cell cycle regulation and mitosis. We hypothesize that there may be a connection between these two processes. In this study, the dynamics of chromosomal (H2B-YFP) and AUR1-GFP changes after enhanced UV-B radiation were observed using confocal microscopy, and gene and protein expression patterns under UV-B stress were quantified using RT-qPCR and Western blotting techniques. We analyzed the responses of the AUR1 overexpression to UV-B stress. We measured maximum quantum yield of photosystem Ⅱ as a proxy for UV-B stress.  https://www.selleckchem.com/products/ulonivirine.html  The recovery capacity of AUR1 overexpression strains was analyzed. In our research, we observed that enhanced UV-B radiation affects the subcellular positioning of AUR1, resulting in abnormalities in the positioning and location of the spindle at the poles, which ultimately affects the separation of chromosomes, resulting in "partition-bundle division" and the incorrect direction of division. At the same time, our results also indicated that low-dose UV-B can induce the expression of AUR1, and this overexpression of AUR1 can alleviate the damage caused by UV-B radiation. In summary, the results of our study show that enhanced UV-B radiation can change the activity and expression of AUR1, which is one of the causes of abnormal chromosome segregation. AUR1 participates in the response to UV-B stress, and, to a certain extent, can improve the UV-B tolerance of plants.C-005 is a novel third-generation EGFR tyrosine kinase inhibitor for the treatment of non-small cell lung cancer (NSCLC). To support its clinical trial, we developed a rapid and sensitive bioanalytical method based on ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) technique for the quantification of C-005 and its major metabolite in NSCLC patients following international bioanalytical guidelines. After a simple and quick protein precipitation step, the supernatant was injected to a Waters Acquity BEH C18 column (2.1 × 50 mm i.d., 1.7 mm), and the column was eluted with a gradient of buffer A (5 mM ammonium acetate and 0.1% formic acid in water) and buffer B (formic acid-acetonitrile (11000, v/v)). The eluates were subsequently detected by an AB QTRAP 5500 mass spectrometer with electrospray ionization using multiple-reaction monitoring mode. The method showed good linearity from 2.00 to 1000 ng/mL for C-005 and 1.00 to 500 ng/mL for M1. In conclusion, the validation results demonstrated the robustness of the method and its well-poised to support the first-in-patient study of C-005 in NSCLC patients.