6% for the no-NACT group (P= .01). The NACT group had fewer recurrences than the no-NACT group (10% vs 47.1%; P= .003). In the subgroup analysis, the lower rate of non-organ-confined disease persisted for the patients who underwent NACT at the lower SV percentage but failed to remain significant at greater percentage involvement. This was also true for overall survival.
 
  The effect of NACT in variant histology bladder cancer is variable. In patients with SV, these results favor the recommendation in favor of NACT administration, particularly when the primary tumor has< 50% involvement by the variant histology.
 The effect of NACT in variant histology bladder cancer is variable. In patients with SV, these results favor the recommendation in favor of NACT administration, particularly when the primary tumor has less then 50% involvement by the variant histology.
  Hump nose in Asians should be managed differently in consideration of the lateral profile and the balance between the dorsal height and nasal tip projection. We suggest an alternative approach comprising mild rasping and nasal tip projection using a septal extension graft.
 
  In this retrospective study, patients who underwent hump nose correction with rhinoplasty between March 2012 and July 2015 were recruited. Instead of applying conventional dorsal augmentation after humpectomy, our approach involved only smooth dorsal contouring in limited cases.  https://www.selleckchem.com/CDK.html  15 patients were evaluated, with surgical outcomes demonstrated using three-dimensional photogrammetry.
 
  Over the postoperative period, hump height decreased (pre 2.77±2.07, post 0.31±0.55, p=0.001). Regarding the efficacy of tip projection, both nasal tip protrusion (pre 17.64±4.82, post 20.46±4.05, p=0.001) and tip projection (pre 19.75±4.26, post 21.83±4.17, p=0.023) were increased. The hump nose reduction ratio was 84.94% after 6 months and 76.47% after 1 year, whereas increases in nasal tip projection and dorsal augmentation were minimal, with ratios of 14.75% and 12.76%, respectively, after 6 months).
 
  Therefore, creating a balance between the nasal tip and nasal dorsum in hump nose correction is more important than dorsal augmentation after hump resection in Asians.
 Therefore, creating a balance between the nasal tip and nasal dorsum in hump nose correction is more important than dorsal augmentation after hump resection in Asians.
  High-rate, persistent criminal offending has substantial negative health consequences. This study examines how criminal offending trajectories during adolescence influence the risk of food insecurity in early adulthood.
 
  The study uses four waves of the National Longitudinal Study of Adolescent to Adult Health to determine the association between criminal offending trajectory membership and food insecurity. The analysis controls for individual- and neighborhood-level risk factors and assesses the mediating effects of depression and household income.
 
  Five distinct offending trajectories were established using a group-based trajectory model. Membership in various offending trajectories predicts an increased risk for food insecurity. Those in high-rate, chronic-offending trajectories have the highest risk of food insecurity in early adulthood (OR=2.062; P<.01). These effects are significantly attenuated by depressive symptoms.
 
  This is the first study to test the association between criminal offending trajectory membership from adolescence through young adulthood and the risk of food insecurity in adulthood. Access to nutrition assistance and support among individuals with chronic-offending histories may minimize the risk of food insecurity. Those embedded in disadvantaged contexts are likely at a heightened risk. Improvements to mental health services and employment opportunities may reduce food insecurity among these vulnerable populations.
 This is the first study to test the association between criminal offending trajectory membership from adolescence through young adulthood and the risk of food insecurity in adulthood. Access to nutrition assistance and support among individuals with chronic-offending histories may minimize the risk of food insecurity. Those embedded in disadvantaged contexts are likely at a heightened risk. Improvements to mental health services and employment opportunities may reduce food insecurity among these vulnerable populations.
  We investigated the thermoregulatory responses to ice slurry ingestion during low- and moderate-intensity exercises with restrictive heat loss.
 
  Randomised, counterbalanced, cross-over design.
 
  Following a familiarisation trial, ten physically active males exercised on a motorised treadmill at low-intensity (L; 40% VO
  ) or moderate-intensity (M; 70% VO
  ) for 75-min, in four randomised, counterbalanced trials. Throughout the exercise bout, participants donned a raincoat to restrict heat loss. Participants ingested 2gkg
  body mass of ambient water (L+AMB and M+AMB trials) or ice slurry (L+ICE and M+ICE trials) at 15-min intervals during exercise in environmental conditions of T
  25.1±0.6°C and RH, 63±5%. Heart rate (HR), gastrointestinal temperature (T
  ), mean weighted skin temperature (T
  ), estimated sweat loss, ratings of perceived exertion (RPE) and thermal sensation (RTS) were recorded.
 
  Compared to L+AMB, participants completed L+ICE trials with lower ΔT
  (0.8±0.3°C vs 0.6±0.2°C; p=0.03), mean be considered to ensure its efficacy.
  It has been well-established that primary bariatric surgery is effective in inducing improvement of diabetes and other associated co-morbidities in patients with obesity. Evidence demonstrating the influence of revisional bariatric surgery on this trajectory, however, is lacking.
 
  We performed a systematic review and meta-analysis to examine the impact of revisional bariatric surgery on obesity-related metabolic outcomes.
 
  University Hospital, Singapore METHODS We examined outcomes of remission and improvement of diabetes, hypertension, hyperlipidemia, and obstructive sleep apnea. Revisional surgeries included sleeve gastrectomy, Roux-en-Y gastric bypass, pouch revision, duodenal switch, and minigastric bypass.
 
  Our search identified 33 relevant studies including a total of 1593 patients. Meta-analysis of proportions demonstrated a 92% improvement in diabetes with 50% achieving remission after revisional bariatric surgery. Of patients, 81% achieved improvement of hypertension with 33% achieving complete remission.