https://www.selleckchem.com/products/ly3200882.html An enantioselective sulfimidation of 3-thiosubstituted 2-quinolones and 2-pyridones was achieved with a stoichiometric nitrene source (PhI=NNs) and a silver-based catalyst system. Key to the success of the reaction is the use of a chiral phenanthroline ligand with a hydrogen bonding site. The enantioselectivity does not depend on the size of the two substituents at the sulfur atom but only on the binding properties of the heterocyclic lactams. A total of 21 chiral sulfimides were obtained in high yields (44-99 %) and with significant enantiomeric excess (70-99 % ee). The sulfimidation proceeds with high site-selectivity and can also be employed for the kinetic resolution of chiral sulfoxides. Mechanistic evidence suggests the intermediacy of a heteroleptic silver complex, in which the silver atom is bound to one molecule of the chiral ligand and one molecule of an achiral 1,10-phenanthroline. Support for the suggested reaction course was obtained by ESI mass spectrometry, DFT calculations, and a Hammett analysis.Intracommunity support and knowledge sharing is used in transgender ("trans") communities as they navigate systems of oppression. Even for individuals with access to accepting families and service providers, connecting with other trans individuals can provide useful insight and resources. Conducted between December 2018 and April 2019, this scoping literature review examines the extent, range and nature of research activity regarding intracommunity knowledge and support sharing within trans communities. Drawing from Weeks' framework regarding sexual communities and the concepts of positive in-group identity and group-level coping, this review specifically addresses the guiding questions of what, how and why knowledge and support are shared within trans communities. Empirical studies conducted between 2004 and 2019 in the United States and Canada that were published in English and had a discernible trans sam