There were no statistically significant differences between the acoustic patterns of /l/ coded as perceptually acceptable and those coded as misarticulated. There was also no apparent effect of vowel and consonant contexts on /l/ patterns. Conclusion The accuracy patterns of this study suggest an earlier development of /l/, especially prevocalic /l/, than has been reported in previous studies. The differences in acoustic patterns between pre- and postvocalic /l/, which become less apparent with age, may suggest that children alter the way they articulate /l/ with age. No significant acoustic differences between acceptable and misarticulated /l/, especially postvocalic /l/, suggest a gradient nature of /l/ that is dialect specific. This suggests the need for careful consideration of a child's dialect/language background when studying /l/.Purpose The current study examines the pattern of misidentified vowels produced by individuals with dysarthria secondary to amyotrophic lateral sclerosis (ALS). Method Twenty-three individuals with ALS and 22 typical individuals produced 10 monophthongs in an /h/-vowel-/d/ context. One hundred thirty-five listeners completed a forced-choice vowel identification test. Misidentified vowels were examined in terms of the target vowel categories (front-back; low-mid-high) and the direction of misidentification (the directional pattern when the target vowel was misidentified, e.g., misidentification "to a lower vowel"). In addition, acoustic predictors of vowel misidentifications were tested based on log first formant (F1), log second formant, log F1 vowel inherent spectral change, log second formant vowel inherent spectral change, and vowel duration. Results First, high and mid vowels were more frequently misidentified than low vowels for all speaker groups. Second, front and back vowels were misidentified at a similar rate for both the Mild and Severe groups, whereas back vowels were more frequently misidentified than front vowels in typical individuals. Regarding the direction of vowel misidentification, vowel errors were mostly made within the same backness (front-back) category for all groups. In addition, more errors were found toward a lower vowel category than toward a higher vowel category in the Severe group, but not in the Mild group. Overall, log F1 difference was identified as a consistent acoustic predictor of the main vowel misidentification pattern. Conclusion Frequent misidentifications in the vowel height dimension and the acoustic predictor, F1, suggest that limited tongue height control is the major articulatory dysfunction in individuals with ALS. Clinical implications regarding this finding are discussed.
  Corticosteroids are important part of acute severe asthma (ASA) management in pediatric intensive care units. Few studies look at the efficacy of inhaled corticosteroids (ICS) in critical care settings. We aimed to investigate the potential beneficial effects of ICS when added to intravenous corticosteroids in pediatric patients with ASA admitted to the pediatric intensive care unit (PICU).
 
  This was a randomized controlled trial involving pediatric patients aged 1-21 years admitted to PICU with ASA. Patients were randomized into 2 groups using block randomization. Patients in Group A received intravenous methylprednisolone (2 mg/kg/day) alone and patients in Group B received intravenous methylprednisolone (2 mg/kg/day) plus budesonide nebulization (0.5 mg every 12 h). Main outcomes were duration of continuous albuterol treatment, PICU and hospital length of stay (LOS), and need and duration of respiratory support.  https://www.selleckchem.com/products/CP-690550.html  Kruskal-Wallis and Chi-square tests were used for statistical analysis, in which a p-value < 0.05 was considered statistically significant.
 
  Duration of continuous albuterol treatment was not different between the 2 groups median/(QR), 30/(18-51) vs. 25/(14-49). (
   = 0.38) PICU and hospital LOS between the 2 groups was similar, median/(QR), 44/(30-64) vs. 46/(30-62), (
   = 0.75) and 78/(65-95) vs.72/(58-92), (
   = 0.19). Number of patients requiring respiratory support was 22(58%) in Group A and 25(64%) in Group B (
   = 0.19).
 
  In critically ill children with ASA, intravenous methylprednisolone combined with inhaled budesonide did not shorten the duration of continuous albuterol inhalation treatment, the PICU and hospital LOS, and the need for respiratory support.
 In critically ill children with ASA, intravenous methylprednisolone combined with inhaled budesonide did not shorten the duration of continuous albuterol inhalation treatment, the PICU and hospital LOS, and the need for respiratory support.Candidiasis caused by multidrug-resistant Candida species continues to be difficult to eradicate. The use of live probiotic bacteria has gained a lot of interest in the treatment of candidiasis; however, whole-cell probiotic use can often be associated with a high risk of sepsis. Strategies manipulating cell-free methods using probiotic strains could lead to the development of novel antifungal solutions. Therefore, we evaluated the effect of three probiotic cell-free extracts (CFEs) on the growth, virulence traits, and drug efflux pumps in C. albicans. On the basis of its minimum inhibitory concentration, Lactobacillus rhamnosus was selected and assessed against various virulence traits and drug resistance mechanisms. The results showed that L. rhamnosus CFE significantly inhibited hyphae formation and reduced secretion of proteinases and phospholipases. Moreover, L. rhamnosus inhibited the drug efflux proteins in resistant C. albicans strains thus reversing drug resistance. Gene expression data confirmed downregulation of genes associated with microbial virulence and drug resistance following treatment of C. albicans with L. rhamnosus CFE. Through gas chromatography - mass spectrometry chemical characterization, high contents of oleic acid (24.82%) and myristic acid (13.11%) were observed in this CFE. Collectively, our findings indicate that L. rhamnosus may potentially be used for therapeutic purposes to inhibit C.albicans infections.Children begin displaying racial biases early in development, which has led many authors of popular-press articles to generate suggestions for preventing and decreasing such biases. One common theme in the popular press is that parents should play a role in addressing children's biases. In the present article, we analyze the current recommendations parents receive about addressing their children's biases and consider their utility. We conclude that the evidence base supporting the effectiveness of parental intervention to reduce children's biases is scant. Next, we offer suggestions for how to construct a useful evidence base from which good recommendations could be drawn. In so doing, we issue a call to action for researchers to conduct research that will yield empirically supported, specific, shareable suggestions for parents who are seeking advice about how to engage with their children in this important domain. We also suggest that researchers become actively involved in the dissemination of the research findings so as to improve the lives of those who receive and express biases.