https://www.selleckchem.com/products/ccg-203971.html 16). The patterns of night shift were all associated with a higher probability of hypertension and participants engaging in rapidly rotating night shift had a lower OR (1.14) than those having slowly rotating night shift (1.23) and permanent night shift (1.46). No significant interaction was observed between the frequency and the pattern of night shift (Pinteraction = 0.281). The frequency and pattern of night shift were associated with hypertension risk in female nurses and no significant interaction was observed between them. The frequency and pattern of night shift were associated with hypertension risk in female nurses and no significant interaction was observed between them. Metabolic syndrome (MetS) is a cluster of different cardiometabolic risk factors (CMRFs), and its different combinations with other CMRFs, such as arterial stiffness have been hypothesized to explain, at least partially, increased risk of cardiovascular disease. Thus, in this systematic review and meta-analysis, we aimed to synthesize the evidence regarding the association between the clustering of MetS-related CMRFs and arterial stiffness measured using pulse wave velocity (PWV). Original studies analysing the association between arterial stiffness, measured using PWV, and MetS were systematically searched. Pooled effect size estimates and their respective 95% confidence intervals (CI) were calculated using the DerSimonian and Laird method for two separate analyses the diagnosis of MetS and PWV values and the number of CMRFs and PWV values. Moderate effect size estimates were observed between MetS and PWV (0.68, 95% CI 0.54-0.82) with a slightly higher effect size for the low-risk compared with the higusly because of the considerable heterogeneity, our findings reinforce the rationale of MetS as an aggregation of risk factors with common causes, which could provide additional useful information to guide clinical management. Findings rega