Background Special feet connected to a prosthesis, prosthetic sports feet, enable athletes with a lower limb amputation to run. The selection of a prosthetic sports feet is usually based on body weight and preferred sports performance. The selection of a prosthetic sport feet is also based on clinicians who likely have limited experience due to a small number of athletes with a lower limb amputation. Hypothesis Athletes with a lower limb amputation are not satisfied with the use and service associated with prosthetic sports feet due to a lack of prosthetic sports feet provision guidelines, poorer function of prosthetic sports feet compared to the anatomical foot and ankle, and limited experience of clinicians. Evaluation of hypothesis A mixed-methods study in 16 athletes with a lower limb amputation using a prosthetic sport foot from Össur or Otto Bock, included semi-structured interviews and quantitative analysis. Three dimensions of prosthetic sports feet were investigated 1) use, 2) provision process, and important dimension of the prosthetic sports feet was its use, which was directly influenced by performance. To further increase the satisfaction with prosthetic sports feet, clinicians should establish how to meet the desired sports performance level of athletes with a lower limb amputation. Improving the process prior to the provision process may increase satisfaction. We suggest increasing the support of professionals during rehabilitation and training through cooperation between involved services, organizing prosthetic sports feet try-out sessions, and increase the accessibility of the prosthetic sports feet. In this way, individuals with a lower limb amputation may become and stay more physically active and participate in sports.Zinc Iodide and Dimethyl Sulfoxide compositions are proposed as therapeutic agents to treat and prevent chronic and acute viral infections including SARS-CoV-2 infected patients. The therapeutic combinations have a wide range of virucidal effects on DNA and RNA containing viruses. The combinations also exhibit anti-inflammatory, immunomodulating, antifibrotic, antibacterial, antifungal and antioxidative effects. Given the fact that Zinc Iodide has been used as an oral antiseptic agent and DMSO has been already proven as a safe pharmaceutical solvent and therapeutic agent, we hypothesize that the combination of these two agents can be applied as an effective, safe and inexpensive treatment for SARS-CoV-2 and other viral infection. The therapeutic compound can be applied as both etiological and pathogenesis therapy and used as an effective and safe antiseptic (disinfectant) for human and animals as well.Alzheimer's disease (AD) is the most prevalent progressive neurodegenerative disease, and the most common cause of dementia. One of the histopathological hallmarks of AD is the accumulation of extracellular amyloid-β (Aβ) oligomers as neuritic plaques in brain. The Aβ oligomers are produced from amyloid precursor protein by the action of secretase enzymes, among which β-secretase 1 (BACE1) catalyses the rate-limiting step. Thus, BACE1 is one of the most important therapeutic targets in preventing deposition of the plaques, progression of the disease, and thus as a disease-modifying therapeutic strategy. The present study was undertaken to isolate and identify novel phytochemicals from the pteridophyte Dipteris wallichii, and to determine their pharmacological properties. A novel compound was eventually detected and named Dip-1, and its pharmacological properties were predicted using computational modelling. The compound was found to have pharmacophores similar to those of known BACE1 inhibitors. Thus, further studies were performed to determine its drug likeness, blood-brain barrier (BBB) permeability, inhibitory potential and IC50 value. The results were promising, and the compound was found to have high drug likeness and BBB permeability, and a potent inhibitor of BACE1, with IC50 value of 0.0372 nM. Thus, the present study reports a novel BACE1 inhibitor from the plant D. wallichii, and is significant owing to its therapeutic implication as a disease-modifying therapy for AD.In this study, polymetal(iod)s-contaminated mining soil from the Huainan coalfield, Anhui, China, was used to investigate the synergistic effects of biochar (BC), raw coal (RC), and hydrothermally treated coal (HTC) on the immobilization, speciation, transformation, and accumulation of Cd, Cr, and Pb in a soil-plant system via geochemical speciation and advanced spectroscopic approaches.  https://www.selleckchem.com/products/sbc-115076.html  The results revealed that the BC-2% and BC-HTC amendments were more effective than the individual RC, and/or HTC amendments to reduce ethylene-diamine-tetraacetic acid (EDTA)-extractable Cd, Cr, and Pb concentrations by elevating soil pH and soil organic carbon content. Soil pH increased by 1.5 and 2.5 units after BC-2% and BC-HTC amendments, respectively, which reduced EDTA-extractable Cd, Cr, and Pb to more stabilized forms. Metal speciation and X-ray photoelectron spectroscopy analyses suggested that the BC-HTC amendment stimulated the transformation of reactive Cd, Cr, and Pb (exchangeable and carbonate-bound) states to less reachable (oxide and residual) states to decrease the toxicity of these heavy metals. Fourier transform infrared spectroscopy and X-ray diffraction analyses suggested that reduction and adsorption by soil colloids may be involved in the mechanism of Cd(II), Cr(VI), and Pb(II) immobilization via hydroxyl, carbonyl, carboxyl, and amide groups in the BC and HTC. Additionally, the BC-2% and BC-HTC amendments reduced Cd and Pb accumulation in maize shoots, which could mainly be ascribed to the reduction of EDTA-extractable heavy metals in the soil and more functional groups in the roots, thus inhibiting metal ion translocation by providing the electrons necessary for immobilization, compared to those in roots grown in the unamended soil. Therefore, the combined application of BC and HTC was more effective than the individual application of these amendments to minimize the leaching, availability, and exchangeable states of Cd, Cr, and Pb in polymetal(iod)s-contaminated mining soil and accumulation in maize.