Data sources A series of eight patients with active COVID-19 who also presented with associated oral lesions seen at a hospital in Sao Paulo, Brazil provided the information in this report.Study selection The authors reported a case series with eight COVID-19 patients.Data extraction and synthesis Demographic information, hospitalisation details including signs, symptoms and severity of COVID-19, along with presence of anosmia, dysgeusia, ageusia and oral lesions from all eight patients were documented and reported by the authors.Results All eight patients in this report presented for medical care with well-established respiratory symptoms of COVID-19. These patients also presented with oral ulcers that resembled aphthous ulcers, of which some also had necrosis and haemorrhagic ulcerations. The time to onset ranged between two to ten days and duration lasted between 5-15 days. The painful ulcers were empirically managed using daily photobiomodulation (PBMT) therapy using a PBMT device (Twin Flex, MMOptics, Sao Carlos, Brazil).Conclusions Oral lesions may precede COVID-19 and progressively worse oral lesions are seen in severe COVID-19 patients. Some of these oral lesions also tend to occur early along with loss of taste and smell in some patients. Taken together, these oral manifestations could serve as early indication of COVID-19 and prompt referral for further testing is recommended.Research question The study aims to investigate spread, distance and spatial distribution of aerosolised microorganisms generated through various endodontic procedures.Study design A case-control study carried out at the University of Maryland, US in 2020. The study investigated the aerosolised microorganisms produced during three endodontic treatments emergency pulpotomy, emergency pulpectomy and non-surgical root canal therapy (NSRCT), with 15 participants in each group (n = 45). Patients diagnosed with symptomatic apical periodontitis were included. The use of settle plates for passive air sampling was employed, in a 4 x 4 m room with closed doors. The number of colony-forming units (CFUs) and composition of bacterial species were analysed. Variables within the study included distance of plate to patient's mouth (0.5 m or 2 m), positioning of plate (directly in front of or diagonal to the participant's mouth), type of endodontic treatment performed and the duration of treatment. A baseline sample was colleamination than an emergency pulpotomy. Greater numbers of microorganisms were found after longer treatment times and closer to the patient's mouth.Design Cross-sectional study/special report.Study population This paper presents the early experience of the oral and maxillofacial surgery department at Hadassah University Medical Centre in Jerusalem during the first wave of the COVID-19 pandemic in 2020. The study involved both medical staff and patients.Data analysis A retrospective analysis of an eight-week period (February-April 2020) collated 1,471 patient records and examined diagnoses, procedures performed and COVID-19 status of patients and staff. Any attempts made to access routine dental care before presentation in secondary care were recorded.Results In the study period, one member of staff was confirmed as COVID-19-positive. Sixty-three patients had formal COVID-19 tests; all were negative. Forty-three patients were admitted for drainage of odontogenic fascial space infections; 53% reported delayed or failed attempts to access dental care before their infection. Additionally, the authors describe a screening process, personal protective equipment (PPE) allocation and staff/patient testing protocols employed in their surgical unit throughout this period.Conclusions The authors suggest a series of triage and screening measures to limit the risk of unknowingly exposing clinical staff to the COVID-19 virus and offer advice on safely delaying non-emergency treatment where necessary. Recommendations for use of PPE for aerosol and non-aerosol generating procedures are made, but it is important to recognise that the efficacy of these measures cannot be determined by the methodology employed. This paper demonstrates an early example of complications developing from absent or delayed routine dental services resulting from lockdowns. This 'excess morbidity' is likely to have an impact on healthcare services as the pandemic recovery unfolds and services begin to return to normal.Data sources PubMed/Medline, Biomed Central, Embase, Thai Journals and the Cochrane library.Study selection Reports or studies dealing with the craniomaxillofacial (CMF) manifestations of COVID-19 were selected.Data extraction and synthesis The reviewers extracted data from the included studies; however, being a meta-narrative review, it was not deemed fit to contact authors for unpublished work, conduct a meta-analysis, search for unpublished data or search for studies in languages different from English, German, French and Thai. The primary variable for prediction was set as the COVID-19 infection, with the primary outcome variable being manifestation in the CMF region. Parameters of a clinical, demographic, investigative and therapeutic nature were the other included variables.  https://www.selleckchem.com/products/MG132.html  Subsequently, the reports and abstracted data were reviewed for study design, author names, country, size of the sample, level of evidence, signs/symptoms, treatment undertaken and investigations conducted. Studies exhibiting the highest level of evidence were included eventually. As deemed appropriate, uni/bivariate and descriptive statistics were applied.Results Cumulatively, 101 publications were included in the meta-narrative after due screening, the data of which was further divided into five groups of 1) nose/paranasal sinus/skull base; 2) mouth/throat; 3) periorbital/ocular tissue; 4) skin; and 5) ear.Conclusions The majority of data pertaining to CMF manifestations of COVID-19 qualifies as a low level of evidence. With the exception of taste/smell dysfunction, most CMF manifestations are nonspecific and can be diagnosed by CMF surgeons and dentists, which underscores their role in battling the pandemic.