This review thus focuses on the clinical and preclinical evidence supporting the existence of sex differences in pain neurobiology. Attention is drawn to the sexually dimorphic role of glial and immune cells, which are both recognized as key players in neuroglial maladaptive plasticity at the origin of the transition from acute pain to chronic pathological pain. Growing evidence notably attributes to microglial cells a pivotal role in the sexually dimorphic pain phenotype and in the sexually dimorphic analgesic efficacy of opioids. This review also summarizes the recent advances in understanding the pathobiology underpinning the development of pain hypersensitivity in both males and females in different types of pain conditions, with particular emphasis on the mechanistic signaling pathways driving sexually dimorphic pain responses.Mitochondrial diseases (MDs) are rare, heterogeneous, hereditary and progressive in nature. In addition to the serious somatic symptoms, patients with MD also experience problems regarding their cognitive functioning and mental health. We provide an overview of all published studies reporting on any aspect of cognitive functioning and/or mental health in patients with MD and their relatives. A total of 58 research articles and 45 case studies were included and critically reviewed. Cognitive impairments in multiple domains were reported. Mental disorders were frequently reported, especially depression and anxiety. Furthermore, most studies showed impairments in self-reported psychological functioning and high prevalence of mental health problems in (matrilineal) relatives. The included studies showed heterogeneity regarding patient samples, measurement instruments and reference groups, making comparisons cautious. Results highlight a high prevalence of cognitive impairments and mental disorders in patients with MD. Recommendations for further research as well as tailored patientcare with standardized follow-up are provided. Key gaps in the literature are identified, of which studies on natural history are of highest importance.The COVID-19 pandemic has led to widespread increases in mental health problems, including anxiety and depression. The development of these and other psychiatric disorders may be related to changes in immune, endocrine, autonomic, cognitive, and affective processes induced by a SARS-CoV-2 infection. Interestingly, many of these same changes can be triggered by psychosocial stressors such as social isolation and rejection, which have become increasingly common due to public policies aimed at reducing the spread of SARS-CoV-2. The present review aims to shed light on these issues by describing how viral infections and stress affect mental health. First, we describe the multi-level mechanisms linking viral infection and life stress exposure with risk for psychopathology. Then, we summarize how resilience can be enhanced by targeting vagus nerve function by, for example, applying transcutaneous vagus nerve stimulation and targeting lifestyle factors, such as exercise. With these biopsychosocial insights in mind, researchers and healthcare professionals will be better equipped to reduce risk for psychopathology and increase resilience during this challenging pandemic period and beyond.Oleuropein, one of the main polyphenolic constituents of olive, is cardioprotective against ischemia reperfusion injury (IRI). We aimed to assess the cardioprotection afforded by acute administration of oleuropein and to evaluate the underlying mechanism. Importantly, since antioxidant therapies have yielded inconclusive results in attenuating IRI-induced damage on top of conditioning strategies, we investigated whether oleuropein could enhance or imbed the cardioprotective manifestation of ischemic postconditioning (PostC). Oleuropein, given during ischemia as a single intravenous bolus dose reduced the infarct size compared to the control group both in rabbits and mice subjected to myocardial IRI. None of the inhibitors of the cardioprotective pathways, l-NAME, wortmannin and AG490, influence its infarct size limiting effects. Combined oleuropein and PostC cause further limitation of infarct size in comparison with PostC alone in both animal models. Oleuropein did not inhibit the calcium induced mitochondritective signaling pathways (RISK, cGMP/PKG, SAFE).The disambiguation effect, also referred to as process of elimination, occurs during word learning, whereby novel words are mapped onto new referents, precluding the application of a novel label to a familiar object. Prior studies showed that the emergence and use of disambiguation can be affected by children's vocabulary growth and linguistic experience, such as growing up with more than one language. To test this, we investigated (a) whether monolingual and multilingual children disambiguated a novel word-object mapping, (b) whether they retained a trained, previously seen word-object mapping, (c) whether they retained the novel fast-mapped word-object mapping, and (d) whether and how age, English vocabulary size, and language background modulated disambiguation and retention.  https://www.selleckchem.com/products/4-hydroxytamoxifen-4-ht-afimoxifene.html  Lastly, we tested (e) whether children who disambiguated also retained better. Eye-tracking data from 18- to 30-month-old monolingual children (n = 43) and multilingual children (n = 40) were collected. A looking-while-listening paradigm with two objects included two familiar items, one novel item, and one trained item. Mixed-effect models reported that vocabulary size predicted the outcome of mapping and retention better than age. Monolingual children's accuracy on disambiguation trials was high from the start, whereas multilingual children started to disambiguate later as their vocabulary grew. Only monolingual children performed above chance level on retaining the novel label. Lastly, the use of disambiguation improved retention for monolingual children but not for multilingual children. This research corroborates that disambiguation should be regarded as a mechanism facilitating default fast mapping rather than fully fledged learning. Vocabulary growth leading to an increase in disambiguation supports the notion that the disambiguation effect stems from prior episodes of learning.