https://www.selleckchem.com/products/zen-3694.html Background Left bundle branch area pacing (LBBAP) is a recently proposed method for conduction system pacing. We performed a meta-analysis of controlled studies to compare the clinical outcome in patients who received LBBAP vs. biventricular pacing (BVP) for cardiac resynchronization therapy (CRT). Methods PubMed, Embase, and Cochrane's Library databases were searched for relevant controlled studies. A random-effect model incorporating the potential heterogeneity was used to synthesize the results. Results Four non-randomized controlled studies including 249 patients with heart failure (HF) for CRT were included, and the patients were followed for 6-12 months. Compared with BVP, LBBAP was associated with significantly shortened QRS duration [mean difference (MD) -29.18 ms, 95% confidence interval (CI) -33.55-24.80, I 2 = 0%, P less then 0.001], improved left ventricular ejection fraction (MD 6.93%, 95% CI 4.69-9.17, I 2 = 0%, P less then 0.001), reduced left ventricular end-diastolic dimension (MD -2.96 mm, 95% CI -5.48 to -0.44, I 2 = 0%, P = 0.02), and improved New York Heart Association class (MD -0.54, 95% CI -0.84 to -0.24, I 2 = 65%, P less then 0.001). Moreover, patients who received LBBAP were more likely to achieve echocardiographic [odds ratio (OR) 5.04, 95% CI 2.17-11.69, I 2 = 0%, P less then 0.001] and clinical (OR 7.33, 95% CI 1.62-33.16, I 2 = 0%, P = 0.01) CRT responses. Conclusion Current evidence from non-randomized studies suggests that LBBAP appears to be a promising method for CRT, which is associated with more remarkable improvements of symptoms and cardiac function in HF patients with indication for CRT.Background Although various biomarkers predict cardiovascular event (CVE) in patients with diabetes, the relationship of urinary glycan profile with CVE in patients with diabetes remains unclear. Methods Among 680 patients with type 2 diabetes, we examined the baseline urinary glycan signals bi