The aim is to study the indexes of short- and long-term mortality in patients after hip fractures (HF). In a retrospective study, the data of 146 women and 82 men with HF aged 50 years and older (mean age (Me [25Q-75Q]) 74.5 [64.7-80.8] years old) hospitalized in 2005-2007 were analyzed.  https://www.selleckchem.com/products/go-6983.html  Life outcome data were collected three times (in 2015, 2016 and 2017) by the researcher by telephone contact with patients or their relatives. The analysis was carried out depending on age, gender, type of fracture, the presence of concomitant diseases. The average follow-up period was 121.3 [30.6-143.9] months (143.4 [133.4-150.0] months for surviving patients and 49.4 [10.2-120.3] months for deceased). Women accounted for 64 % of all subjects with HF and were significantly older than men. The average age at the time of death for the deceased (81.2 [72.2-85.1] years) was significantly higher in women (82.0 [72.9-86.8]) compared with men (76, 8 [66.3-84.8] years; Z=2.0; p=0.04), although it did not differ from the indexes of survivors at the end of the study (79.2 [72.8-89.4] years). Hospital mortality rates were 1.3%, 6-month, 1-, 5- and 10-year mortality, respectively - 11.8%, 18.4%, 36.8 \% and 48.2%. Mortality rate was higher in men only in the age group of 80-89 years, while there were no significant differences in mortality depending on the type of fracture. Survival rates did not differ depending on gender, type of fracture, and were significantly higher (p=0.004) in the patients older than 70 years compared with younger patients.Objective - to improve the results of treatment of patients with chronic ischemia of the lower extremities based on optimization of the technique of operations on the deep femoral artery. During 6 years (from 2014 to the end of 2019), 150 patients were initially operated on for obliterating atherosclerosis of the femoropopliteal-tibial segment of the lower extremities in the department of vascular surgery of the Andrey Novak Regional Clinical Hospital, the clinical base of the Uzhgorod National University. In the presence of "short" stenoses, preference should be given to open endarterectomy with an autovenous and / or autoarterial patch. With extended stenoses, the essence of profundoplasty is again reduced to the restoration and expansion of the lumen by endarterectomy with an autovenous patch and/or by bypassing or prosthetics of the DFA segment. The choice of reconstruction is also influenced by the presence of enveloping and piercing branches at the site of the required level of disinfection. If the length of the DFA stenosis is up to 4 cm, regardless of the plaque density, it is recommended to open the EAE with autovenous, autoarterial and/or aloinsertion. With a stenosis length of 4 to 10 sm with a soft or medium density atherosclerotic plaque, an open EAE with an autovenous patch is shown. If the lesion is more than 10 cm long, regardless of the density of the atherosclerotic plaque, femoral-deep femoral shunting and/or prosthetics are recommended. When prosthetics of the DFA and the diameter of the perforating and/or circumflex arteries is ≥2 mm and the preserved retrograde blood flow, their reimplantation on the site into the prosthesis is indicated.We present a case of androgen and glucocorticoid secreting adrenocortical carcinoma with concomitant myelolipoma. A giant adrenal tumor which was initially nonfunctional was reassessed four years later due to the patient's refusal to treat. The patient was a 48-year-old woman with hypertension and acne lesions on the face. Laboratory findings were consistent with glucocorticoid and androgen hypersecretion. Computed tomography revealed a heterogeneously contrasting mass of 145x118x100 mm with lobular contour and soft tissue areas. The patient underwent left laparoscopic transperitoneal adrenalectomy with three port technique. There were no complications in the perioperative period. The resected specimen weighed 850 grams. Pathological findings showed a combination of myelolipoma-adrenal cortical cancer. In the postoperative period, hypertension improved and the hormone panel was normalized. Postoperative computed tomography and PET-CT showed no residual mass and metastasis. Although imaging is compatible with benign masses such as myelolipoma, coexistence of ACC-myelolipoma should be kept in mind and functional evaluation should be performed.The fuzzy planar cell polarity protein (Fuz) is an effector component of the planar cell polarity (PCP) signaling. Together with other core and effector proteins, the PCP pathway controls polarized cell movements. Fuz was also reported as a negative regulator of cell survival. In this study, we performed a pan-cancer survey to demonstrate the role of Fuz in multiple types of cancer. In head-neck squamous cell carcinoma and lung adenocarcinoma tumor samples, a reduction of Fuz transcript expression was detected. This coincides with the poor overall survival probabilities of these patients. We further showed that Fuz promoter hypermethylation contributes to its transcriptional downregulation. Meanwhile, we also identified a relatively higher mutation frequency at the 404th arginine amino acid residue in the coding sequence of Fuz locus, and further demonstrated that mutant Fuz proteins perturb the pro-apoptotic function of Fuz. In summary, our study unveiled an intriguing relationship between Fuz dysregulation and cancer prognosis, and further provides mechanistic insights of Fuz's involvement in carcinogenesis.Vulvovaginal atrophy (VVA) is a common menopause-related symptom affecting more than 50% of midlife and older women and cancer patients whose ovarian function are lost or damaged. Regardless of estrogen deficiency, whether other factors such as the gut microbiota play role in VVA have not been thoroughly investigated. To this end, we performed ovariectomy on 12-weeks' old mice and follow-up at 4 weeks after ovariectomy, and observed atrophied vagina and an altered gut microbiota in ovariectomized mice.. We further performed fecal microbiota transplantation with feces from another cohort of ovary-intact fecund female mice to the ovariectomized ones, and found that the vaginal epithelial atrophy was significantly alleviated as well as the gut microbiota was pointedly changed. All these results suggest that ovarian activity has some influence on the gut microbiota, and the latter from the ovary-intact female mice can somehow make the vagina of mice deficient in ovarian function healthier maybe by up-expressing ESR1 in vaginal cells and enhancing regeneration in vagina.