Evidence for school-level variables as predictors of bullying victimization profiles was stronger for adolescents in the United States, with a concentration of affluent families and severity of delinquency being significant in four of the six models. For the South Korean sample, the severity of delinquency predicted bullying victimization in only one model. Examination of both individual- and school-level factors that predict unique bullying victimization experiences grounded in Social Disorganization Theory may be informative for addressing key areas of intervention-especially at the school-level context in which victimization primarily takes place and where anti-bullying intervention programs are often provided.
  To evaluate the clinical value of high mobility group box-1 (HMGB1) expression levels in patients with gastric cancer.
 
  Articles published from January 2000 to August 2022 were searched using PubMed, Google Scholar and Science Direct, Springer, Wiley and NIH to evaluate the clinicopathological significance of HMGB1 expression in gastric cancer.
 
  A total of 156 publications were selected, of which six studies, comprising 846 patients, met the criteria for inclusion in this study. Forest plots of clinicopathological characteristics indicated that HMGB1 expression was not associated with age (odds ratio (OR) = 1.07, 95% confidence interval (CI) 0.89-1.28), sex (OR = 0.90, 95% CI 0.81-1.00), TNM (OR = 1.39, 95% CI 0.82-2.37), N stage (OR = 1.42, 95% CI 0.97-2.07), or tumor differentiation (OR = 0.96, 95% CI 0.71-1.29), but was highly correlated with pT stage (OR = 1.56, 95% CI 1.17-2.07). Funnel plots showed no significant publication bias in the included studies in terms of age, sex, TNM, pT stage, N stage, or tumor differentiation.
 
  HMGB1 expression was significantly correlated with tumor pT stage, but not with age, sex, TNM stage, tumor N stage, tumor differentiation, or lymphatic metastasis in patients with GC.
 HMGB1 expression was significantly correlated with tumor pT stage, but not with age, sex, TNM stage, tumor N stage, tumor differentiation, or lymphatic metastasis in patients with GC.
  To evaluate the feasibility of quantitative enhancing lesion volume (ELV) for evaluating the responsiveness of breast cancer patients to early neoadjuvant chemotherapy (NAC) using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI).
 
  Seventy-five women with breast cancer underwent DCE-MRI before and after NAC. Lesions were assessed by ELV, response evaluation criteria in solid tumors 1.1 (RECIST 1.1), and total lesion volume (TLV). The diagnostic and pathological predictive performances of the methods were compared and color maps were compared with pathological results.
 
  ELV identified 29%, 67%, and 4% of cases with partial response, stable disease, and progressive disease, respectively. There was no significant difference in evaluation performances among the methods. The sensitivity, specificity, positive predictive value, negative predictive value (NPV), and accuracy of ELV for predicting pathologic response were 72%, 92%, 81.8%, 86.8%, and 85.3%, respectively, with the highest sensitivity, NPV, and accuracy of the three methods. The area under the receiver operating characteristic curve was also highest for ELV. Pre- and post-NAC color maps reflecting tumor activity were consistent with pathological necrosis.
 
  ELV may help evaluate the responsiveness of breast cancer patients to NAC, and may provide a good tumor-response indicator through the ability to indicate tumor viability.
 ELV may help evaluate the responsiveness of breast cancer patients to NAC, and may provide a good tumor-response indicator through the ability to indicate tumor viability.
  To better understand approaches to reducing mortality from the opioid epidemic, we analyzed in-hospital versus community opioid-related overdose deaths in Illinois.
 
  We used data from the Statewide Unintentional Drug Overdose Reporting System (July 2017 through December 2018) to identify deaths that occurred in hospitals and communities (ie, homes or public spaces). We used census tract-level data for 34 Illinois counties to create bivariate mapping by overdose death rates. We used logistic regression to analyze the association of demographic and overdose characteristics with the likelihood of death in a hospital versus a community.
 
  During the study period, 2833 opioid-related overdose deaths occurred in 24 Illinois counties, 655 (23.1%) of which occurred in the hospital; of 2178 community deaths, 1888 (86.7%) occurred in the same census tract as the decedent's recorded residence and 1285 (59.0%) occurred in the decedent's home. Non-Hispanic Black people were 1.63 (95% CI, 1.27-2.10) times more likely thect in reducing the number of opioid-related overdose deaths.This study examines how multivariate trajectory patterns of overt and relational peer and dating violence perpetration, alcohol use, and nonviolent deviant behavior during high school predict convictions in adulthood. Adolescent data are from an accelerated cohort design study that spanned four waves in 2003-2005. In 2019, conviction records were obtained for a random subsample of 1,579 individuals from the original study. We identified latent classes that were jointly characterized by distinct behavioral trajectories and adult conviction status, and described the demographic and psychosocial profiles of each class. The best-fitting model comprised four trajectory classes Low Deviance (44%), Moderate Stable Deviance (40%), Increasing Deviance (8%), and Dating Violence Perpetrators (8%). Adolescents whose deviance increased during adolescence had substantially higher risk of convictions, including violent convictions, than all other groups.  https://www.selleckchem.com/products/yoda1.html  Classes were differentiated by gender, household structure, parental education, school bonding, grades, emotional dysregulation, sensation-seeking, family conflict, and prosocial values. The Increasing Deviance class was predominantly male, had an elevated probability of coming from a single-parent household and of having parents with low education, but values on psychosocial indicators were not extreme. Dating Violence Perpetrators were also more likely to come from a single-parent household, but their parents tended to have more education. This group was the most extreme on several psychosocial indicators that indicate low school and family bonds, and poor emotional regulation. The implications of these patterns in relation to interactional and strain theories, theories of cognitive maturation, and theories of social bonds and social control are discussed.