cial support, disclosing their HIV status, and getting early treatment for any opportunistic infection is crucial to patients.
  Eculizumab, a drug that blocks activation of the terminal complement pathway, is useful in the treatment of several rare diseases. However, eculizumab-related meningococcal disease is a serious problem. Because of the difficulty diagnosing meningococcal disease, deaths from meningococcal disease may have been overlooked. The purpose of this study was to clarify the trend of meningococcal infection in patients on eculizumab and to evaluate the effectiveness of risk communication.
 
  Pharmacovigilance analysis was conducted using the Japanese Adverse Drug Event Report database between the first quarter of 2010 and the second quarter of 2019. Of the reports of deaths, those with adverse event terms of fever, shock, altered state of consciousness, loss of consciousness, sepsis, organ failure, and disseminated intravascular coagulation were analyzed as deaths with suspected meningococcal infection.
 
  Of the 3559.2 person-years of eculizumab-exposed patients, 17 patients died with symptoms of meningococcal diseaseunication reduced the fatality rate of meningococcal disease.
 The analysis of the database showed that death from meningococcal disease in eculizumab-exposed individuals may occur more often than expected. This study also showed that appropriate risk communication reduced the fatality rate of meningococcal disease.Replacing missing teeth distal to the last standing teeth with removable partial dentures poses considerable challenge to dentists. However, the insertion of implants turns a free-end saddle into a bounded saddle. Still, patients may not be able to accept implant insertions due to financial reasons, systemic medical conditions, local anatomical factors or complicated treatments involving surgery. Hence, patients with missing teeth often prefer to use removable partial dentures to improve their dental aesthetics and to restore their oral function. In this article, we use a clinical case to illustrate the clinical procedures required for the fabrication of a distal extension denture with good retention, support, stability, aesthetics and masticatory function. We also review the design for a clasp assembly on the abutment adjacent to the distal edentulous ridge.
  Information on periodontal disease and its predictors in sub-Saharan Africa is sparse. This study aimed to determine the prevalence of periodontal disease and assess the relationship with associated factors in patients who attended the University of Gondar comprehensive hospital.
 
  A hospital-based cross-sectional study was conducted from October 1, 2019, to March 10, 2020, at the University of Gondar comprehensive Hospital. Participants were recruited with a systematic random sampling technique, and interviewed for sociodemographic and medical information through a structured questionnaire. Two examiners evaluated the periodontal status of the study participants using the community periodontal index (CPI).
 
  Four hundred twenty participants were involved in the study. The mean age of the study participants was 29.87 (±7. 76). The majority of the study participants had a habit of tooth brushing (72.1%) and almost half of them did not have a fixed time to brush their teeth.  https://www.selleckchem.com/products/wnt-c59-c59.html  Periodontal change (CPI>0) was noted in 42.4% of the participants and among that 21.7% had shallow pocket (pocket depth of 4-5 mm) and 5.95% had a deep periodontal pocket (≥6 mm). The prevalence was higher in 20-34 years (57.3%), females (58.98%), monthly income of <2500 ETB (82.02%), and frequent carbohydrate intakes (65.17%). Age (AOR=9.61, 95% CI 6.42, 13.04), gender (AOR=2.00, 95% CI 136, 2.97), educational status (AOR=3.25), residency (AOR= 1.66), monthly income (AOR=2.13), oral hygiene habit (AOR=4.85) and systemic disease (AOR=1.96) were significantly associated with periodontitis.
 
  In the present study, 42.4% of the study participants encountered periodontal disease. The study confirmed that various sociodemographic risk factors/indicators are associated with an increased risk of periodontitis.
 In the present study, 42.4% of the study participants encountered periodontal disease. The study confirmed that various sociodemographic risk factors/indicators are associated with an increased risk of periodontitis.
  Biopsy remains the gold standard for determining fibrosis stage in patients with primary biliary cholangitis (PBC), but it is unavailable for most patients. We used data from the 11 US health systems in the FibrOtic Liver Disease Consortium to explore a combination of biochemical markers and electronic health record (EHR)-based diagnosis/procedure codes (DPCs) to identify the presence of cirrhosis in PBC patients.
 
  Histological fibrosis staging data were obtained from liver biopsies. Variables considered for the model included demographics (age, gender, race, ethnicity), total bilirubin, alkaline phosphatase, albumin, aspartate aminotransferase (AST) to platelet ratio index (APRI), Fibrosis 4 (FIB4) index, AST to alanine aminotransferase (ALT) ratio, and >100 DPCs associated with cirrhosis/decompensated cirrhosis, categorized into ten clusters. Using least absolute shrinkage and selection operator regression (LASSO), we derived and validated cutoffs for identifying cirrhosis.
 
  Among 4328 PBC patients, or clinical follow-up.
 An algorithm using laboratory results and DPCs can categorize a majority of PBC patients as cirrhotic or noncirrhotic with high accuracy (with a small remaining group of patients' cirrhosis status indeterminate). In the absence of biopsy data, this EHR-based model can be used to identify cirrhosis in cohorts of PBC patients for research and/or clinical follow-up.
  Reproducibility of clinical and epidemiologic research is important to generalize findings and has increasingly been scrutinized. A recently published randomized trial, PIVOTAL, evaluated high vs low intravenous iron dosing strategies to manage anemia in hemodialysis patients in the UK. Our objective was to assess the reproducibility of the PIVOTAL trial findings using data from a well-established cohort study, the Dialysis Outcomes and Practice Patterns Study (DOPPS).
 
  To overcome the absence of randomization in the DOPPS, we applied the parametric g-formula, an extension of standardization to longitudinal data. We estimated the effect of a proactive high-dose vs reactive low-dose iron supplementation strategy on all-cause mortality (primary outcome), hemoglobin, two measures of iron concentration (ferritin and TSAT), and erythropoiesis-stimulating agent dose over 12 months of follow-up in 6325 DOPPS patients.
 
  Comparing high- vs low-iron dose strategies, the 1-year mortality risk difference was 0.020 (95% CI 0.