Finally, the feet position adopted during the heel-raise task (neutral vs. internally rotated) affected only the GL neural drive with no change for GM. These results provide conclusive evidence that not all anatomically defined synergist muscles are controlled by strong common neural drive. Independent drive to some muscles from the same muscle group may allow for more flexible control to comply with secondary goals such as joint stabilization.NEW & NOTEWORTHY In this study, we demonstrated that the three muscles composing the human triceps surae share minimal common drive during isometric contractions. Our results suggest that reducing the number of effectively controlled degrees of freedom may not always be the strategy used by the central nervous system to control movements. Independent control of some, but not all, synergist muscles may allow for more flexible control to comply with secondary goals (e.g., joint stabilization).The plantar fascia (PF), a primary contributor of the foot arch elasticity, may experience slack, taut, and stretched states depending on the ankle and metatarsophalangeal (MTP) joint positions. Since PF has proximodistal site difference in its dimensions and stiffness, the response to applied tension can also be site specific. Furthermore, PF can contribute to supporting the foot arch while being stretched beyond the slack length, but it has never been quantitatively evaluated in vivo. This study investigated the effects of the ankle and MTP joint positions on PF length and localized thickness and shear wave velocity (SWV) at three different sites from its proximal to distal end using magnetic resonance and supersonic shear imaging techniques. During passive ankle dorsiflexion, rise of SWV, an indication of slack length, was observed at the proximal site when the ankle was positioned by 10°-0° ankle plantar flexion with up to 3 mm (+1.5%) increase in PF length. On the other hand, SWV increased at the distal f human bipedal locomotion.This study compared the effectiveness of dynamic resistance training (DRT) versus isometric RT (IRT) on osteogenesis and hormonal mechanisms involved in maintenance hemodialysis (MHD) patients. One hundred and ninety-three MHD patients were randomized into three groups control (CTL) (n = 60), DRT (n = 66), and IRT (n = 67). A first visit was required for an anamnesis to evaluate the number of medications, biochemical, and anthropometric measurements (dialysis adequacy, creatinine, urea, body mass, height, and body mass index). Grip strength, bone mineral density (BMD), and renal-bone markers were assessed pre- and postprotocol. The DRT and IRT training was 6 mo with a frequency of three times per week, on alternate days. Each training session consisted of three sets of 8 to 12 repetitions at lower and moderate intensities. Both training sessions were prescribed approximately 1 h prior to dialysis. Statistical significances were adopted with P less then 0.05. There was a greater dropout in the IRT group (24%these benefits. Therefore, this study supports the potential therapeutic role of dynamic resistance training counteracting chronic kidney disease-mineral and bone disorder.Inadequate hyperventilation and inefficient alveolar to arterial gas exchange are gas exchange challenges that can limit capacity and cause exercise-induced arterial hypoxaemia (EIAH). This work evaluated if the prevalence of gas exchange inefficiencies, defined as AaDO2>25 mmHg, PaCO2>38 mmHg, and/or ΔPaO2>-10 mmHg at any point during constant-load exercise in healthy, active, but not highly trained, individuals suggested an innate sex difference that would make females more susceptible to EIAH. Sixty-four healthy, active males and females completed 18-min of cycling exercise (moderate and vigorous intensity, 9 min/stage).  https://www.selleckchem.com/products/zotatifin.html  Arterial blood gases were measured at rest and every 3-min during exercise, while constantly assessing gas exchange. Both sexes demonstrated similar levels of AaDO2 widening until the final 3 min of vigorous exercise, where females demonstrated a trend for greater widening than males (16.3±6.2 mmHg vs. 19.1±6.0 mmHg, p=0.07). Males demonstrated a blunted ventilatory response to moderate exercise with higher PaCO2 (38.5±2.6 vs. 36.5±2.4, p=0.002) and a lower ventilation when corrected for workload (0.42±0.1 vs. 0.48±0.1, p=0.002). No significant arterial hypoxaemia occurred, but in 6 M and 5 F SaO2 dropped by ≥2%. There was no difference in prevalence of pulmonary gas exchange inefficiencies between sexes, but the type of inefficiency was influenced by sex.Abbreviations AaDO2 alveolar-arterial oxygen difference; BP blood pressure; EIAH exercise-induced arterial hypoxaemia; F females; HR heart rate; M males; Q cardiac output; PaCO2 arterial partial pressure of carbon dioxide; PaO2 arterial partial pressure of oxygen; ΔPaO2 change in arterial partial pressure of oxygen; PAO2 alveolar partial pressure of oxygen; RPE rating of perceived exertion; SaO2 arterial oxygen saturation; VE ventilation; VE/VCO2 ventilatory equivalent for carbon dioxide; VO2PEAK peak oxygen consumption; WMAX workload maximum.Nickel (Ni), the main responsible for allergic contact dermatitis worldwide, is also involved in systemic condition called "Systemic Nickel Sulfate Allergy Syndrome (SNAS)." Likewise, IgE-mediated reactivity to Lipid Transfer Protein (LTP) represents the main cause of primary food allergy in adults of Mediterranean countries. We evaluated the prevalence of SNAS in LTP allergic patients and investigated patients' clinical features with double sensitization (LTP and Ni). A retrospective, single-center, observational study was conducted performing a complete allergological work-up including (1) skin prick tests; (2) serum specific IgE for plant food allergens and rPru p3 (LTP); (3) patch test with 5% Ni sulfate in petrolatum. We enrolled 140 LTP allergic patients of which 36 patients (25.7% of sample) showed additional positivity to Ni patch test. Patients with double sensitization were more frequently females and reported fewer cutaneous symptoms. Higher values of sIgE for peach, apple, peanut, walnut, grain, corn, and garlic were found in LTP allergic patients, while higher values for hazelnut in the other subgroup.