Finally, we predict the region stimulated by AGE-BSA is located in region V of RAGE and 13 amino acids are critical for its binding. In conclusion, the activation of RAGE affects platelet activation and 13 amino acids are critical for its stimulation, this information is crucial for future possible treatments for CVD.Arabinoxylan (AX) has many beneficial health effects that are closely related to its structural characteristics. The current study aimed to investigate the effects of molecular weight (Mw) and degree of substitution (DS) on the antioxidant and hypoglycemic activities of triticale bran AX and its hydrolysates in vitro. At low and similar Mw, the antioxidant activity of AX was inversely proportional to its DS. When DS was close, the antioxidant activity of AX was inversely proportional to its Mw at high DS, but the opposite result was found at low DS. As for the hypoglycemic performance, when DS was similar, the hypoglycemic activity of AX was proportional to its Mw. At low and similar Mw, the α-glucosidase inhibitory ability and glucose adsorption ability of AX was positively correlated with DS, whereas the α-amylase inhibitory ability and glucose delayed absorption ability showed the opposite results. Mw and DS had significant effects on the antioxidant and hypoglycemic activities of AX, and these two factors often need to be combined to explain the varied effects under different conditions.We report a facile approach for the preparation of protein conjugated glutaric acid functionalized Fe3O4 magnetic nanoparticles (Pro-Glu-MNPs), having improved colloidal stability and heating efficacy. The Pro-Glu-MNPs were prepared by covalent conjugation of BSA protein onto the surface of glutaric acid functionalized Fe3O4 magnetic nanoparticles (Glu-MNPs) obtained through thermal decomposition. XRD and TEM analyses confirmed the formation of crystalline Fe3O4 nanoparticles of average size ~5 nm, whereas the conjugation of BSA protein to them was evident from XPS, FTIR, TGA, DLS and zeta-potential measurements. These Pro-Glu-MNPs showed good colloidal stability in different media (water, phosphate buffer saline, cell culture medium) and exhibited room temperature superparamagnetism with good magnetic field responsivity towards the external magnet. The induction heating studies revealed that the heating efficacy of these Pro-Glu-MNPs was strongly reliant on the particle concentration and their stabilizing media. In addition, they showed enhanced heating efficacy over Glu-MNPs as surface passivation by protein offers colloidal stability to them as well as prevents their aggregation under AC magnetic field. Further, Pro-Glu-MNPs are biocompatible towards normal cells and showed substantial cellular internalization in cancerous cells, suggesting their potential application in hyperthermia therapy.Most phenolic resins are synthesized with non-renewable petroleum-based phenol and formaldehyde, which have adverse effects on the environment and human health. To achieve green and sustainable production of phenolic resins, it is important to replace non-renewable toxic phenol and formaldehyde. Herein, a new strategy was proposed to completely replace phenol and formaldehyde, using lignin-derived monomers to synthesize renewable phenolic resins. Lithium aluminum hydride was utilized to reduce lignin-derived monomers, including vanillin, methyl vanillate, and syringaldehyde, to generate the corresponding vanillyl and syringic alcohol. With oxalic acid as the catalyst, vanillyl and syringic alcohol could be polymerized to phenolic resins without using formaldehyde. The structure of the phenolic resins based on lignin-derived monomers was analyzed by Fourier transform infrared spectroscopy and 13C and 31P nuclear magnetic resonance spectroscopy. Differential scanning calorimetry and thermogravimetric analysis were performed to characterize the thermal properties of the phenolic resins. The phenolic resins based on lignin-derived monomers exhibited excellent adhesion strength (6.14 MPa), glass transition temperature (Tg) (107-115 °C), and thermal stability, and its performance was similar to that of the commercial Novolak phenolic resin. This study presents a promising green and sustainable approach to synthesize renewable phenolic resins based on lignin-derived monomers without using formaldehyde.The hippocampus is involved in learning and memory for novel information and implicated within the cognitive dysfunction in Parkinson's disease. Long-term potentiation (LTP), the most type of synaptic plasticity, is the base of learning and memory. We evaluated the consequences of apelin-13 on early long-term potentiation (E-LTP) in the Cornu Ammonis (CA1) area of the hippocampus and synaptic hippocampal protein expression of postsynaptic density protein 95 (PSD-95) and dopaminergic receptor (DR1) of the rat model of Parkinsonism. 6-hydroxydopamine (6-OHDA) was infused within the right substantia nigra. Intra-nigral transfusion of apelin-13 (1, 2, and 3 μg/rat) was performed one week after the 6-OHDA injection. Using hematoxylin and eosin staining, the pathological changes in the substantia nigra neurons were examined. In Vivo field excitatory postsynaptic potentials were recorded in the CA1 region one month after the apelin injection. The PSD-95 and DR1 protein levels were assessed by western blotting. The mRNA expression level of DR1 was also measured by real-time PCR. 6-OHDA meaningfully disrupted short-term memory and LTP, and altered the expression levels of the above-mentioned proteins in the hippocampus. The results suggest that apelin-13 (especially at 3 μg/rat) significantly ameliorates the E-LTP impairment and attenuates the changes in hippocampal synaptic proteins in 6-OHDA-treated rats.Neuropeptides are involved in numerous brain activities being responsible for a wide spectrum of higher mental functions. The purpose of this concise, structural and qualitative investigation was to map the possible immunoreactivity of the novel neuropeptide spexin (SPX) within the human magnocellular hypothalamus.  https://www.selleckchem.com/products/hygromycin-b.html  SPX is a newly identified peptide, a natural ligand for the galanin receptors (GALR) 2/3, with no molecular structure similarities to currently known regulatory factors. SPX seems to have multiple physiological functions, with an involvement in reproduction and food-intake regulation recently revealed in animal studies. For the first time we describe SPX expressing neurons in the supraoptic (SON) and paraventricular (PVN) nuclei of the human hypothalamus using immunohistochemical and fluorescent methods, key regions involved in the mechanisms of osmotic homeostasis, energy expenditure, consummatory behaviour, reproductive processes, social recognition and stress responses. The vast majority of neurons located in both examined neurosecretory nuclei show abundant SPX expression and this may indirectly implicate a potential contribution of SPX signalling to the hypothalamic physiology in the human brain.