For decades, several attempts have been made to obtain a mimetic model for the study of metastasis, the reason of most of deaths caused by cancer, in order to solve the unknown phenomena surrounding this disease. To better understand this cellular dissemination process, more realistic models are needed that are capable of faithfully recreating the entire and essential tumor microenvironment (TME). Thus, new tools known as tumor-on-a-chip and metastasis-on-a-chip have been recently proposed. These tools incorporate microfluidic systems and small culture chambers where TME can be faithfully modeled thanks to 3D bioprinting. In this work, a literature review has been developed about the different phases of metastasis, the remaining unknowns and the use of new models to study this disease. The aim is to provide a global vision of the current panorama and the great potential that these systems have for in vitro translational research on the molecular basis of the pathology. In addition, these models will allow progress toward a personalized medicine, generating chips from patient samples that mimic the original tumor and the metastatic process to perform a precise pharmacological screening by establishing the most appropriate treatment protocol.One-dimensional Si nanostructures with carbon coating (1D Si@C) show great potential in lithium ion batteries (LIBs) due to small volume expansion and efficient electron transport. However, 1D Si@C anode with large area capacity still suffers from limited cycling stability. Herein, a novel branched Si architecture is fabricated through laser processing and dealloying. The branched Si, composed of both primary and interspaced secondary dendrites with diameters under 100 nm, leads to improved area capacity and cycling stability. By coating a carbon layer, the branched Si@C anode shows gravimetric capacity of 3059 mAh g-1 (1.14 mAh cm-2 ). At a higher rate of 3 C, the capacity is 813 mAh g-1 , which retained 759 mAh g-1 after 1000 cycles at 1 C.  https://www.selleckchem.com/products/nivolumab.html  The area capacity is further improved to 1.93 mAh cm-2 and remained over 92% after 100 cycles with a mass loading of 0.78 mg cm-2 . Furthermore, the full-cell configuration exhibits energy density of 405 Wh kg-1 and capacity retention of 91% after 200 cycles. The present study demonstrates that laser-produced dendritic microstructure plays a critical role in the fabrication of the branched Si and the proposed method provides new insights into the fabrication of Si nanostructures with facility and efficiency.In this study, four different MnO2 polymorphs are synthesized with a controlled morphology of hollow porous structures to systematically investigate the influences of polymorphs in conversion-based material. As the structure of these materials transforms into nanosized metal and maintains an extremely low-crystalline phase during cell operation, the effects of polymorphs are overlooked as compared to the case of insertion-based materials. Thus, differences in the ion storage behaviors among various MnO2 polymorphs are not well identified. Herein, the structural changes, charge storage reaction, and electrochemical performance of the different MnO2 polymorphs are investigated in detail. The experimental results demonstrate that the charge storage reactions, as part of which spinel-phased MnO2 formation is observed after lithiation and delithiation instead of recovery of the original phases, are similar for all the samples. However, the electrochemical performance varies depending on the initial crystal structure. Among the four polymorphs, the spinel-type λ-MnO2 delivers the highest reversible capacity of ≈1270 mAh g-1 . The structural similarity between the cycled and pristine states of λ-MnO2 induces faster kinetics, resulting in the better electrochemical performance. These findings suggest that polymorphs are another important factor to consider when designing high-performance materials for next-generation rechargeable batteries.Obstructive sleep apnea (OSA) is a risk of hypertension and is associated with cardiovascular disease (CVD) incidence. In Asian countries, the prevalence of OSA is high, as in Western countries. When blood pressure (BP) is evaluated in OSA individuals using ambulatory BP monitoring (ABPM), the BP phenotype often indicates abnormal BP variability, such as increased nighttime BP or abnormal diurnal BP variation, that is, non-dipper pattern, riser pattern, and morning BP surge, and all these conditions have been associated with increased CVD events. Asians have a higher prevalence of increased nighttime BP or morning BP surge than Westerners. Therefore, this review paper focused on OSA and hypertension from an Asian perspective to investigate the importance of the association between OSA and hypertension in the Asian population. Such abnormal BP variability has been shown to be associated with progression of arterial stiffness, and this association could provoke a vicious cycle between abnormal BP phenotypes and arterial stiffness, a phenomenon recognized as systemic hemodynamic atherothrombotic syndrome (SHATS). OSA may be one of the background factors that augment SHATS. An oxygen-triggered nocturnal oscillometric BP measurement device combined with a pulse oximeter for continuous SpO2 monitoring could detect BP variability caused by OSA. In addition to treating the OSA, accurate and reliable detection and treatment of any residual BP elevation and BP variability caused by OSA would be necessary to prevent CVD events. However, more detailed detection of BP variability, such as beat-by-beat BP monitoring, would further help to reduce CV events.
  Obstructive pulmonary disease may cause some psychiatric disorders such as depression, similar to other chronic diseases. Patients with chronic obstructive pulmonary disease or asthma are especially susceptible to inhaler technique errors. The aim of this study was to evaluate the depression that can affect improper use of inhaler devices and to show the contribution of age, sex, and education to correct usage.
 
  In this study, trained health care workers in the presence of Chest specialist requested patients to demonstrate their inhaler technique and assessed it according to the checklist. If any of the steps were missing or done incorrectly, it was marked as an incorrect technique.
 
  We included 188 participants, mean age of 58.3±12.7years. Significant variables of individual risk were having comorbidities, age, sex, smoking status, and educational level. There was an inverse relationship between education level and incorrect inhaler technique. Even after controlling for age, gender, and education, depressive symptoms were a significant and independent predictor of improper use of inhaler devices.