We found that exclusion of small glands led to improvement in classification accuracy. Using an inclusion threshold of 200 nuclei per gland, our final model classification accuracy was 77.5% in the validation set, with a positive predictive value of 0.81. We leveraged this high positive predictive value in a point cloud overlay display to assist end-user identification of EIN foci. This study demonstrates that graph theory approaches applied to small-scale anatomic elements in the endometrium allow biologic classification by machine learning, and that spatial superimposition over large-scale tissue expanses can have practical diagnostic utility. We expect this augmented diagnostic approach to be generalizable to commonly encountered problems in other organ systems. © 2020 The Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.Tanycytes are glial cells in the hypothalamus that are functionally part of the blood-brain barrier. They can sense nutrients and metabolites in the circulation such as glucose, then signal to neuronal systems to influence ingestive behaviour and energy storage, and ultimately affect body weight. The complex structure of tanycytes underpins this function, and communication is dependent upon connexin-43 gap junctions between tanycytes. This Editorial highlights studies by Recabal and coworkers (Recabal et al., 2020) in the current issue that shed some light on how this happens, and on how FGF2 might induce plasticity in hypothalamic structure through changes in tanycyte function that are dependent on connexin-43 hemichannels. This Editorial Highlights the article https//doi.org/10.1111/jnc.15188.
  Resection is the mainstay of treatment for colorectal liver metastases (CRLMs). Many different histopathological factors related to the primary colorectal tumour have been well studied; however, histopathological prognostic factors related to CRLMs are still under evaluation.
 
  To identify histopathological factors related to overall survival (OS) and disease-free survival (DFS) in patients with resected CRLMs.
 
  A systematic review was performed with the following databases up to August 2020 PubMed, EMBASE, Web of Science, SciELO, and LILACS. The GRADE approach was used to rate the overall certainty of evidence by outcome.
 
  Thirty-three studies including 4,641 patients were eligible. We found very low certainty evidence that the following histopathological prognostic factors are associated with a statistically significant decrease in OS presence of portal vein invasion (HR, 0,50 [95% CI, 0,37 to 0,68]; I²=0%), presence of perineural invasion (HR, 0,55 [95% CI, 0,36 to 0,83]; I²=0%), absence of pseudocapsule (HR, 0,41 [CI 95%, 0,29 to 0,57], p<0,00001; I²=0%), presence of satellite nodules (OR, 0,45 [95% CI, 0,26 to 0,80]; I²=0%), and the absence of peritumoural inflammatory infiltrate (OR, 0,20 [95% CI, 0,08 to 0,54]; I²=0%). Outcome data on DFS were scarce, except for tumour borders, which did not present a significant impact, precluding the meta-analysis.
 
  Of the histopathological prognostic factors studied, low- to moderate-certainty evidence shows that vascular invasion, perineural invasion, absence of pseudocapsule, presence of satellite nodules, and absence of peritumoral inflammatory infiltrate are associated with shorter overall survival in CRLMs.
 Of the histopathological prognostic factors studied, low- to moderate-certainty evidence shows that vascular invasion, perineural invasion, absence of pseudocapsule, presence of satellite nodules, and absence of peritumoral inflammatory infiltrate are associated with shorter overall survival in CRLMs.Choosing the right anaesthetic technique and postoperative analgesia after major surgery can be a great challenge for paediatric anaesthetists, especially when younger children are concerned. The simultaneous use of systemic analgesics with adjuncts in combination with single-shot blocks performed at the right time may facilitate the patient's recovery and result in a comfortable postoperative period.Regional anaesthetic techniques are an indispensable element of acute and postoperative pain management.  https://www.selleckchem.com/products/sy-5609.html  The benefits of regional blocks are particularly noticeable in trauma and orthopaedic, joint reconstruction or thoracic surgical procedures. Depending on the local anaesthetic (LA) used, the duration of analgesia is limited to a maximum of 12-16 hours. There are several methods affecting the prolongation of analgesia, e.g. continuous techniques with catheters, liposomal forms of LAs or adjuvants. Due to numerous limitations and problems associated with the use of continuous techniques, lack of approval or availability of liposomal LAs, the optimal measure to prolong the duration of postoperative analgesia is the use of adjuvants. The present study aims to collect and systematise the current knowledge about the most common adjuvants used for nerve / plexus blockades and intravenous regional anaesthesia.The coronavirus disease (COVID-19) was previously unknown, and we are learning about it day by day, but pandemic-associated ethical dilemmas have been studied and discussed for years. Triage means not only ranking in terms of importance (prioritisation) but also allocation of limited medical resources. Survival, post epidemic-quality of life, and consumption of medical resources required to achieve the set goal are crucial for making triage decisions. The pandemic triage decisions should be based on a protocol, considering the need for medical measures and therapy benefits. The first step is to consider the exclusion criteria and the risk of death. The next step is sequential clinical assessment, repeatable at defined intervals. It seems that the preferable solution is to triage all the patients and give priority to those who would benefit more. A prerequisite for allocating insufficient medical resources is public trust in the criteria for allocation.
  SpO2, heart rate, and systolic, diastolic, and mean arterial blood pressure are among the commonly applied and most frequently chosen indicators of well-being of newborns in intensive care units. Objective to determine the relationship between the aforementioned parameters and the status of newborns depending on the outcome of the Infant Flow (I-F) therapy, and the development of complications in the form of pneumothorax.
 
  A retrospective single-centre study covering the years 2009-2014. A total of 182 neonates, with mean gestational age 34.1 weeks and mean body weight 2226 g, were analysed. The minimum and maximum values of the evaluated parameters were analysed statistically according to the therapy outcome noted as success or failure.
 
  A successful outcome of I-F therapy (71.4%) was characterised by higher SpO2 (93.3 ±7.28 vs. 85.9 ±14.77 at P < 0.001; 99.95 ±0.31 vs. 98.6 ±3.30 at P < 0.0001), lower heart rate (122.5 ±12.37 vs. 135.9 ±14.97 at P < 0.0001), and higher max systolic blood pressure (79.