Core training effectively improves sport performance. The purpose of this study was to determine the effect of core training on the performance measures of speed, agility and quickness of U19 male football players.
 
  A total of 24 young male football players were divided into 12 in the experimental group (aged 18.17±0.72) and 12 in the control group (aged 18.31±0.75). The experimental group performed 30-35 min core training three days a week for eight weeks while the control group continued their routine training. Measurements included a 40-meter sprint test for speed, a hexagon test for quickness and an agility-T test for agility. Pre-test measurements at the start of the study and post-test measurements after eight weeks were compared by an ANOVA 2×2. A significant level of P<0.05 was established.
 
  In the experimental group, there were an improvement in quickness (pre 17.27±3.24"; post 16.79±3.09"; P=0.005, η<sup>2</sup>=0.53) and agility (pre 12.86±1.17"; post 12.38±1.12"; P=0.003, η<sup>2</sup>=0.56), but the speed did not change (pre 6.14±0.57"; post 6.00±0.45", P=0.653).
 
  The use of core training in combination with normal football training is shown to be effective in improving quickness and agility but not speed among young male football players after a period of eight weeks. So, it appears reasonable to include specific core training programs within football training.
 The use of core training in combination with normal football training is shown to be effective in improving quickness and agility but not speed among young male football players after a period of eight weeks. So, it appears reasonable to include specific core training programs within football training.Not available.
  The objective of the article is to describe the follow-up of pregnancies at work and occupational exposure to potential risks for pregnancy.
 
  A descriptive cross-sectional study was performed from April1, 2017 to October31, 2017 in the occupational health departments of French hospitals. After delivery and at the time of returning to work, 1,165eligible workers were interviewed by occupational health physicians (OHPs). Socio-demographic information was self-reported. Occupational exposures were assessed by an OHP. Birth weight, gestational age, and sick leaves were also collected.
 
  Among recruited workers, 51.8% were exposed to more than 5 occupational hazards. Biological and physical hazards were the most common hazards at the workplace. Note that heavy lifting≥15kg concerned 9.5% of workers. Only 20.1% of workers had a specific "pregnancy at work" medical visit with OHP during pregnancy; 26.8% benefited from workstation adjustments.  https://www.selleckchem.com/mTOR.html  In contrast, the level of sick leaves was high (86.7%).
 
  Our data suggest that pregnant workers in hospitals must be strictly supervised.
 Our data suggest that pregnant workers in hospitals must be strictly supervised.SARS-CoV-2, a member of the coronavirus family, has caused a global public health emergency. Based on our analysis of hepatitis C virus and coronavirus replication, and the molecular structures and activities of viral inhibitors, we previously reasoned that the FDA-approved hepatitis C drug EPCLUSA (Sofosbuvir/Velpatasvir) should inhibit coronaviruses, including SARS-CoV-2. Here, using model polymerase extension experiments, we demonstrate that the active triphosphate form of Sofosbuvir is incorporated by low-fidelity polymerases and SARS-CoV RNA-dependent RNA polymerase (RdRp), and blocks further incorporation by these polymerases; the active triphosphate form of Sofosbuvir is not incorporated by a host-like high-fidelity DNA polymerase. Using the same molecular insight, we selected 3'-fluoro-3'-deoxythymidine triphosphate and 3'-azido-3'-deoxythymidine triphosphate, which are the active forms of two other anti-viral agents, Alovudine and AZT (an FDA-approved HIV/AIDS drug) for evaluation as inhibitors of SARS-CoV RdRp. We demonstrate the ability of two of these HIV reverse transcriptase inhibitors to be incorporated by SARS-CoV RdRp where they also terminate further polymerase extension. Given the 98% amino acid similarity of the SARS-CoV and SARS-CoV-2 RdRps, we expect these nucleotide analogues would also inhibit the SARS-CoV-2 polymerase. These results offer guidance to further modify these nucleotide analogues to generate more potent broad-spectrum anti-coronavirus agents.NS gene is generally considered to be related to the virulence of highly pathogenic avian influenza virus (AIV). In recent years, the strains with five amino acids added to the 80-84 positions of the NS1 protein have become prevalent in H5N1 subtype AIVs isolated from mammals. However, the pathogenicity and mechanism of this pattern in mammals remain unclear. In this study, H5N1 subtype AIVs without 80-84 amino acids of the NS1 protein (rNSΔ5aa ) and a mutant virus (rNS5aa-R ) with no deletion of 80-84 amino acids of the NS1 protein were used to determine the pathogenicity in mice. Our results showed that rNS5aa-R possessed an enhanced pathogenicity compared with rNSΔ5aa in vivo and in vitro, which was accompanied by high expression of IL-6, MX1 and CXCL10 in murine lungs. Furthermore, we found that rNS5aa-R increased the infection ability to dendritic cells (DCs). Besides, rNS5aa-R enhanced the expression of phenotypic markers (CD80, CD86, CD40 and MHCII), activation marker CD69, inflammatory cytokines (IL-6, TNF-α and IL-10) and antagonized interferon (IFN-α) of DCs, in comparison to rNSΔ5aa . Moreover, rNS5aa-R induced DCs to quickly migrate into nearby cervical lymph nodes by highly upregulating CCR7, and CD86 showed a high expression on the migrated DCs. We also found that rNS5aa-R -infected DCs significantly promoted the allogeneic CD4+ T-cell proliferation. These findings suggested that rNS5aa-R strongly induced the innate immune response compared with the rNSΔ5aa , which is conducive to activate a wide immune response, resulting in a strong cytokine storm and causing an enhanced pathogenicity of H5N1 subtype AIVs in mammals.
  In vitro efficacy of pro- and antihemostatic drugs is profoundly different in patients with compensated cirrhosis and in those who have cirrhosis and are critically ill.
 
  Here we assessed the efficacy of pro- and anticoagulant drugs in plasma of patients undergoing hepato-pancreato-biliary (HPB) surgery, which is associated with unique hemostatic changes.
 
  We performed in vitro analyses on blood samples of 60 patients undergoing HPB surgery and liver transplantation 20 orthotopic liver transplantations, 20 partial hepatectomies, and 20 pylorus-preserving pancreaticoduodenectomies. We performed thrombin generation experiments before and after in vitro addition of fresh frozen plasma (FFP), prothrombin complex concentrate (PCC), recombinant factor VIIa (rFVIIa), low molecular weight heparin (LMWH), unfractionated heparin, dabigatran, and rivaroxaban.
 
  We showed that patients undergoing HPB surgery are in a hypercoagulable state by thrombin generation testing. FFP and rFVIIa had minimal effects on thrombin generation, whereas PCC had a more pronounced procoagulant effect in patients compared with controls.