https://www.selleckchem.com/products/butyzamide.html The remaining 20% had edge loading, where implants had inclination ≤5° of planned positioning and 10° of planned anteversion. 60% were ≤10° of planned inclination and anteversion. No pre-operative planned positions were within 'Lewinneks's zone', indicating its questionable relevance, especially in HR. A total of 20% of patients developed pain; however, at 1 year post-operatively all patients recorded improved Oxford hip scores. This study confirms that functional positioning in HR consistently results in improved precision and accuracy in achieving the functional acetabular ideal zone, leading to improved clinical outcomes and prevention of edge loading. This study confirms that functional positioning in HR consistently results in improved precision and accuracy in achieving the functional acetabular ideal zone, leading to improved clinical outcomes and prevention of edge loading.Atom-by-atom substitution is a promising strategy for designing new cluster-based materials, which has been used to generate new gold- and silver-containing clusters. Here, the first study focused on atom-by-atom substitution of Fe and Ni to the core of a well-defined cobalt sulfide superatom [Co6 S8 L6 ]+ ligated with triethylphosphine (L = PEt3 ) to produce [Co5 MS8 L6 ]+ (M = Fe, Ni) is reported. Electrospray ionization mass spectrometry confirms the substitution of 1-6 Fe atoms with the single Fe-substituted cluster being the dominant species. The Fe-substituted clusters oxidize in solution to generate dicationic species. In contrast, only a single Ni-substituted cluster is observed, which remains stable as a singly charged species. Collision-induced dissociation experiments indicate the reduced stability of the [Co5 FeS8 L6 ]+ toward ligand loss in comparison with the unsubstituted and Ni-substituted counterparts. Density functional theory calculations provide insights into the effect of metal atom substitution on the stability and