Care Med 2020;24(11)1028-1036.
  To describe the demographics and evaluate the clinical outcomes of hypoxic coronavirus disease-2019 (COVID-19) patients treated with different immunomodulatory (IM) drugs in a resource-limited setting.
 
  We conducted a retrospective cohort study of these patients admitted to our hospital between March 22 and May 31, 2020. Data were abstracted from multiple electronic data sources or patient charts to provide information on patient characteristics, clinical, laboratory variables, and outcomes.
 
  A total of 134 patients met the inclusion criteria and were followed up till June 7, 2020. The median age of the patients was 55.6 years (range 20-89 years) and 68% were men. At least one comorbidity was seen in 72% of the patients with diabetes (44%) and hypertension (46%) being the most common. At triage, fever (82%), shortness of breath (77%), and cough (61%) were the most common presenting symptoms. A PaO
  /FiO
  ratio less than 300 was seen in 60%, and 4.5% required invasive mechanical ventilation within 72 hourc COVID-19 Patients Treated with Immunomodulatory Drugs in a Tertiary Care Hospital. Indian J Crit Care Med 2020;24(11)1020-1027.Pediatric index of mortality (PIM)-2 and PIM3 are the most recent versions of severity of illness scoring generated from a pediatric intensive care unit (PICU) population in Australia and the United Kingdom. The authors present a single-center evaluation of a performance of these scores in a PICU in Colombia. PIM3 seemed to demonstrate a marginally better performance at predicting mortality, although the discrimination was similar for both scores. Incorporation of this approach to the rest of the units throughout the country would help with benchmarking PICU performance.
  Rahiman S. Does Pediatric Index of Mortality "Score" in Colombia? Indian J Crit Care Med 2020;24(11)1018-1019.
 Rahiman S. Does Pediatric Index of Mortality "Score" in Colombia? Indian J Crit Care Med 2020;24(11)1018-1019.Coronavirus disease-2019 (COVID-19) has been testing the boundaries of science on several fronts. Pharmacotherapy has seen the highs of several drugs being tried as the best option as well as the lows of no drug proven to be effective. In this edition of the Indian Journal of Critical Care Medicine, Mahale et al. retrospectively evaluated a combination of drugs targeted at immunomodulation.
  Samavedam S. Immunomodulation and COVID-19 Is There a Winning Combination? Indian J Crit Care Med 2020;24(11)1015-1017.
 Samavedam S. Immunomodulation and COVID-19 Is There a Winning Combination? Indian J Crit Care Med 2020;24(11)1015-1017.How to cite this article Iyer S. Dietary Fiber Is It Hype or Useful? Indian J Crit Care Med 2020;24(11)1014.How to cite this article Tyagi N. Where Has All the "HES" Gone A Case in Point vs "Crusade" to Obscurity. Indian J Crit Care Med 2020;24(11)1012-1013.Severe acute respiratory syndrome-coronavirus-2 (SARS CoV-2) is a novel virus. There has been an increasing number of case reports on multisystem inflammatory syndrome in children (MIS-C) but the global and population-specific incidence of MIS-C particularly in Asian countries, its causal relationship with SARS-CoV-2 and its immunopathogenesis remain unknown. Emerging questions on how the pathophysiology of MIS-C differs from that of Kawasaki disease (KD) and non-KD inflammatory syndromes need to be answered. Genetic factors influencing the incidence of MIS-C in the different ethnic populations are to be explored. What happens to the children with MIS-C, in the long run, remains unknown to date. Multicenter clinical trials are needed to establish optimal treatment and follow-up for MIS-C.
  Bhattacharyya P. Multisystem Inflammatory Syndrome of Children Related to SARS-CoV-2 A Novel Experience in Children with a Novel Virus. Indian J Crit Care Med 2020;24(11)1010-1011.
 Bhattacharyya P. Multisystem Inflammatory Syndrome of Children Related to SARS-CoV-2 A Novel Experience in Children with a Novel Virus. Indian J Crit Care Med 2020;24(11)1010-1011.How to cite this article Kothekar AT. Combined Cardiopulmonary Ultrasound A Treatment Changing Modality in Acute Respiratory Failure. Indian J Crit Care Med 2020;24(11)1008-1009.Reduction in the maternal mortality ratio (MMR) continues to be a worldwide challenge. With repeated analytical studies done over decades, it has become possible to identify the significant contributors to this challenge. Right from low socioeconomic status to the availability of recent technological advances, many factors need attention and prioritization. Obstetric hemorrhage remains an important cause followed by hypertensive disorders of pregnancy and sepsis.  https://www.selleckchem.com/products/pco371.html  In this issue of IJCCM, Miglani et al. have highlighted the various levels of the delays, which are significant contributors to the high MMR. In other preventive strategies, efforts will be needed to improve patient education, infrastructure, availability of trained manpower, blood storage facilities, timely referrals, transport facilities, etc., at peripheral levels. In the tertiary care centers, there is an increased need for trained manpower in critical care, the obstetric medical emergency team as a new concept, aggressive teamwork in intensive care unit (ICU) and operation theaters, the use of advanced technologies and newer drugs, etc. It will remain a tough challenge to reduce global MMR to 70 per 100,000 live births, as per plans by the United Nations, by the year 2030.
  Bande BD. Critically Ill Obstetric Patients and Fetomaternal Outcome. Indian J Crit Care Med 2020;24(11)1005-1007.
 Bande BD. Critically Ill Obstetric Patients and Fetomaternal Outcome. Indian J Crit Care Med 2020;24(11)1005-1007.Developmental anomalies are marked deviations from normal size, shape, contour, and various other parameters. An understanding of these anomalies and its application has been a clinical challenge. With the advances in diagnostic technology, the field of endodontics has been evolving with new treatment protocols, which gives promising results. The aim of this article is to present a case report on tooth anomaly that is taurodontism and its management in a patient with multiple taurodont teeth. This article brings discussion on anatomical variations of the taurodont teeth and the techniques related to the endodontic treatment of the same and how it differs from normal teeth.