BACKGROUND Uterine rupture is a rare obstetric emergency, and the rate of rupture has increased over time with the rising rate of caesarean section (CS) and trial of labour after CS (TOLAC). AIM To determine the prevalence, and maternal and neonatal complications associated with complete uterine rupture at a New Zealand (NZ) tertiary referral hospital over an 11-year period. MATERIAL AND METHODS This is a retrospective, observational study. Waikato Hospital records of patients with uterine rupture occurring between 2008 and 2018 were reviewed for risk factors, delivery outcomes, and maternal and neonatal complications. RESULTS There were 32 patients with complete uterine rupture in 38 182 births, conferring a prevalence of 8.4 per 10 000 births (95% CI 5.9-11.8). Of the 29 cases occurring during labour, 83% of patients were multiparous, 59% previously had one or two CS; patients with an unscarred uterus had lower rates of emergency CS and high rates of postpartum haemorrhage than patients with a scarred uterus. There were no maternal deaths although three patients required peripartum hysterectomy, 63% required blood transfusion and there were five (16%) perinatal deaths. CONCLUSION The prevalence of uterine rupture in this NZ tertiary hospital is comparable to other developed countries. There was no maternal mortality but there was a 16% perinatal death rate. Patients with spontaneous labour and an unscarred uterus were not exempt from this rare complication. There is a need to manage labour judiciously in all patient groups and to maintain a high level of suspicion for uterine rupture. © 2020 The Royal Australian and New Zealand College of Obstetricians and Gynaecologists.PURPOSE Needle-based procedures for diagnosing and treating prostate cancer, such as biopsy and brachytherapy, have incorporated three-dimensional (3D) transrectal ultrasound (TRUS) imaging to improve needle guidance. Using these images effectively typically requires the physician to manually segment the prostate to define the margins used for accurate registration, targeting, and other guidance techniques. However, manual prostate segmentation is a time-consuming and difficult intraoperative process, often occurring while the patient is under sedation (biopsy) or anesthetic (brachytherapy). Minimizing procedure time with a 3D TRUS prostate segmentation method could provide physicians with a quick and accurate prostate segmentation, and allow for an efficient workflow with improved patient throughput to enable faster patient access to care. The purpose of this study was to develop a supervised deep learning-based method to segment the prostate in 3D TRUS images from different facilities, generated using multiprovement across nearly all metrics.  https://www.selleckchem.com/Bcl-2.html  A computation time less then 0.7 s per prostate was observed, which is a sufficiently short segmentation time for intraoperative implementation. CONCLUSIONS Our proposed algorithm was able to provide a fast and accurate 3D segmentation across variable 3D TRUS prostate images, enabling a generalizable intraoperative solution for needle-based prostate cancer procedures. This method has the potential to decrease procedure times, supporting the increasing interest in needle-based 3D TRUS approaches. This article is protected by copyright. All rights reserved.A better understanding regarding the mechanisms by which the rumen processes feed may assist us in identifying animals with superior feed efficiency. Studies to evaluate the gene expression of rumen tissue have previously been performed to analyze their relationship with feed efficiency. Continuing this research is critical to determine whether the expression of the genes identified is associated with feed efficiency in additional populations of beef cattle to ensure that they are robust across breed and environment. A previous rumen-transcriptome study on Hereford × Angus steers identified 122 differentially expressed genes (PFDR   less then  0.05) associated with residual feed intake (RFI), a measure of feed efficiency. The purpose of our study was to test the most divergent, up- and down-regulated genes in the rumen tissue of an unrelated population of Hereford × Angus steers that included two contemporary groups. A total of 13 genes were evaluated by quantitative real-time PCR. The centromere-associated protein E (CENPE) gene was expressed in lower concentrations in the rumen epithelium of steers in the more efficient (low RFI) group in both contemporary groups of animals, which was the same as the previous study. In addition, CENPE, a gene involved in chromosome alignment during mitosis, has also been associated with growth traits in cattle and pigs. There was no relationship between the expression of the other 12 genes tested with RFI in the population of steers in this study, which illustrates the importance of validating gene expression data in additional populations. © 2020 Stichting International Foundation for Animal Genetics.Salmo fahrettini, new species, is described from the northern tributaries of the Euphrates River. It differs from Salmo species in adjacent water by the combination of the following characters a greyish body; one black spots behind eye and on cheek; three to six black spots on opercle; numerous black spots on back (missing on predorsal area), flank and middle part of body, surrounded by a roundish white ring; red spots in median part of body, surrounded by a roundish white ring; maxilla short and narrow; number of black and red spots increasing with increasing size; adipose fin medium size, no or rarely one red spot its posterior edge; 109-117 lateral line scales; 27-30 scales rows between dorsal-fin origin and lateral line; 20-23 scale rows between lateral line and anal-fin origin; maxilla length 8.8-10.0% SL in males, 8.8-9.6 in females. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.PURPOSE The dose response of Gafchromic EBT3 films exposed to proton beams depends on the dose, and additionally on the beam quality, which is often quantified with the linear energy transfer (LET) and, hence, also referred to as LET quenching. Fundamentally different methods to determine correction factors for this LET quenching effect have been reported in literature and a new method using the local proton fluence distribution differential in LET is presented. This method was exploited to investigate whether a more practical correction based on the dose- or fluence-averaged LET is feasible in a variety of clinically possible beam arrangements. METHODS The relative effectiveness (RE) was characterized within a high LET spread-out Bragg peak (SOBP) in water made up by the six lowest available energies (62.4-67.5 MeV, configuration " b 1 ") resulting in one of the highest clinically feasible dose-averaged LET distributions. Additionally, two beams were measured where a low LET proton beam (252.7 MeV) was superimposed on " b 1 ", which contributed either 50% of the initial particle fluence or 50% of the dose in the SOBP, referred to as configuration " b 2 " and " b 3 ," respectively.