001) and 15.3 mm Hg at the last visit ( =0.004). The mean medications reliance reduced in both groups, in PGE group was reduced from 1.62 preoperatively to 0.13 at the last visit ( <0.001), in PG group from 0.87 to 0.10 ( <0.001). At the last visit, BCVA increased from 0.21 to 0.60 in PGE group ( <0.001) and from 0.24 to 0.67 in PG group ( <0.001). The success rate of PGE group at 1mo was 95.2%, then decreased to 70.7% at the last visit, whereas in PG group, the success rate at 1mo was 100%, at the last visit was 73.4%. PGE shows promise for PACG patients with cataracts to reduce IOP, lighten the medication burden and improve visual acuity, and PG still has its value in specific patients. PGE shows promise for PACG patients with cataracts to reduce IOP, lighten the medication burden and improve visual acuity, and PG still has its value in specific patients. To evaluate the accuracy of eight different intraocular lens (IOL) power calculation formulas for a segmented multifocal IOL. A total of 53 eyes of 41 adult cataract patients who underwent phacoemulsification and implantation with the SBL-3 segmented multifocal IOL between January 1, 2017 and January 31, 2019 were included in this retrospective study. Preoperative biometry measurements were obtained using an IOL Master. Manifest refraction was performed at least 4wk postoperatively. Accuracy of the eight formulas [Barrett Universal II, Emmetropia Verifying Optical (EVO), Haigis, Hill-RBF 2.0, Hoffer Q, Holladay 1, Kane, and SRK/T] was analyzed. Using current lens constants, all formulas exhibited errors of slight myopic shift in refractive prediction. The Barrett Universal II formula had a significantly lower median absolute error (MedAE) than did Holladay 1 ( =0.02), Kane ( =0.001) and Hill-RBF 2.0 ( <0.001) formulas. The Haigis formula had a lower MedAE value than did the Hill-RBF 2.0 formula ( =0.005). Differences in MedAE values among SRK/T, EVO and Hoffer Q formulas were not significant. After optimizing lens constants, the MedAE values of all formulas were reduced; significant changes were noted for EVO ( =0.022), Haigis ( =0.048), Hill-RBF 2.0 ( =0.014), Holladay 1 ( =0.045) and Kane ( =0.022) formulas. All formulas performed equally well after optimization of lens constants ( =0.203). All eight formulas tend to result in a myopic shift when using current lens constants. Optimized lens constants improve the accuracy of these formulas among adult Chinese patients. All eight formulas tend to result in a myopic shift when using current lens constants. Optimized lens constants improve the accuracy of these formulas among adult Chinese patients. To determine if there is any difference in long term graft survival between Descemet's stripping endothelial keratoplasty (DSEK) and penetrating keratoplasty (PK). A retrospective 5-year cases analysis of bullous keratopathy secondary to Fuchs' endothelial dystrophy or pseudophakic bullous keratopathy, receiving either DSEK or PK. https://www.selleckchem.com/products/deg-35.html A total of 42 DSEK cases and 25 PK cases were included in the analysis. In the 5-year analysis, graft survival rates were very similar in the two groups (DSEK 77.1% PK 76.0%, =0.918, 95%CI -6.3 to 33.4). Sub-analyses at 1y (DSEK 81% PK 95%, =0.085, 95%CI -29 to 3.6) and 2y (DSEK 81% PK 88%, =0.381, 95%CI -25.9 to 11.8) show a trend towards lower survival rates of DSEK PK, but the results were not statistically significant. Long term 5-year graft survival is similar between the DSEK and PK methods of corneal transplant in Chinese patients with bullous keratopathy. Long term 5-year graft survival is similar between the DSEK and PK methods of corneal transplant in Chinese patients with bullous keratopathy. To study the effect of uncrosslinked and crosslinked hyaluronic acid combined with other artificial tear components in patients with dry eye caused by moderate meibomian gland dysfunction. Prospective, single-blind, contralateral eye study. Fifty eyes (25 patients) were analyzed. Eye selection for each tear type was random, and the eye drop formulations, 0.4% uncrosslinked hyaluronic acid and 0.2% galactoxyloglucan (tear A) and 0.15% crosslinked hyaluronic acid, crocin, and liposomes (tear B) were used. The determined dosing schedule was three times a day for six weeks, and the study participants underwent a clinical examination before and 45d after lubricant treatment. The Schirmer test, tear breakup time (TBUT) test, and Ocular Surface Disease Index (OSDI) questionnaire were applied before and after instillation period with both types of artificial tears. On the Schirmer test, a significant improvement was obtained with both tear A ( <0.01) and tear B ( <0.01). On the TBUT test, a significant improvement was obtained with tear A ( <0.01) and tear B ( <0.01). The OSDI score significantly decreased after instillation period with both artificial tear types ( <0.01). Uncrosslinked hyaluronic acid combined with other components, such as tamarind seed polysaccharide, and crosslinked hyaluronic acid combined with liposomes and crocin are effective for management symptoms of dry eye disease. Uncrosslinked hyaluronic acid combined with other components, such as tamarind seed polysaccharide, and crosslinked hyaluronic acid combined with liposomes and crocin are effective for management symptoms of dry eye disease. To investigate whether inhibition of acetylcholinesterase (AChE) by donepezil ameliorate aberrant retinal neovascularization (RNV) and abnormal glial activation in oxygen-induced retinopathy (OIR). A mouse model of RNV was induced in postnatal day 7 (P7) mice by exposure to 75% oxygen. Donepezil was administrated to P12 mice by intraperitoneal injection. Expression and localization of AChE in mouse retinas were determined by immunofluorescence. RNV was evaluated by paraffin sectioning and hematoxylin and eosin (HE) staining. Activation of retinal Müller glial cells were examined by immunoblot of glial fibrillary acidic protein (GFAP). rMC-1, a retinal Müller cell line, was used for study. Expression of hypoxia-induced factor 1α (HIF-1α) and vascular endothelial growth factor (VEGF) were determined by Western-blot analysis, enzyme-linked immunosorbent assay (ELISA) or immunostaining. Aberrant RNV and glial activation was observed after OIR. Of note, retinal AChE was mainly expressed by retinal Müller glial cells and markedly increased in OIR mice.