Chitin is a promising natural polymer with great potential as a biomedical, hygiene, absorbent, and food-packing material. Producing chitin multifilament and assembling them into textiles is an efficient way of preparing these materials, with wet-spinning a major method used to produce man-made fibers. Unfortunately, dissolving chitin, producing a stable and suitable chitin dope, and ensuring filament strength are the main obstacles to the production of chitin multifilament. Based on recent research into chitin dissolution, solution properties, and high-strength chitin-based materials, chitin multifilament wet-spinning is no longer only a hypothetical strategy. Here, a pilot-scale wet-spinning method is introduced that overcomes the abovementioned limitations. A stable chitin spinning dope is prepared by dissolution and aging in an aqueous KOH/urea solution. A chitin multifilament is prepared by wet-spinning using a pilot-scale wet-spinning apparatus and aqueous alcohol/salt coagulation. After deacetylation, the chitosan multifilament possesses a dense structure and low crystallinity, but excellent mechanical properties. The chitin/chitosan multifilaments exhibit excellent cytocompatibilities and have promising prospects in biomedical applications. The method developed in this work provides a new approach for the pilot-scale wet-spinning of chitin/chitosan multifilaments.Despite recent substantial advances in perovskite materials, their 3D integration capability for next-generation electronic devices is limited owing to their inherent vulnerability to heat and moisture with degradation of their remarkable optoelectronic properties during fabrication processing. Herein, a facile method to transfer the patterns of perovskites to planar or nonplanar surfaces using a removable polymer is reported. After fabricating perovskite devices on this removable polymer film, the conformal attachment of this film on target surfaces can place the entire devices on various substrates by removing this sacrificial film. This transfer method enables the formation of a perovskite image sensor array on a soft contact lens, and in vivo tests using rabbits demonstrate its wearability. Furthermore, 3D heterogeneous integration of a perovskite photodetector array with an active-matrix array of pressure-sensitive silicon transistors using this transfer method demonstrates the formation of a multiplexed sensing platform detecting distributions of light and tactile pressure simultaneously. Published guidelines are available to assist in the management of patients with inherited bleeding disorders in the elective surgical setting however good quality outcome data is lacking. - Evaluate the outcomes of adult patients with inherited bleeding disorders, who received factor replacement for elective surgery in NSW/ACT, Australia. - Assess adherence to relevant guidelines including Haemophilia Treatment Centre (HTC) utilisation and appropriate factor replacement. A retrospective analysis was performed between 2000 and 2018 to describe patient characteristics, surgical details, factor provision and outcomes. Univariate analysis was used to determine variables associated with guideline adherence. Covariates with p<0.1 were included in the multivariate analysis. A total of 1065 surgeries were performed on 571 patients. Diagnoses included Haemophilia A (43.5%), Haemophilia B (9.7%), von Willebrand disease (VWD) (45.3%) and rare bleeding disorders (RBDs) (1.6%). Bleeding complications were reporguidelines exists highlighting areas of practice and policy discrepancies that warrant further exploration. To estimate during pregnancy correlations between frequency of self-reported use of marijuana and quantified marijuana metabolite in biospecimens including urine, sera and umbilical cord homogenate. Prospective cohort. Two urban hospitals in Colorado with legal recreational and medicinal marijuana. Pregnant women (<16weeks gestation) self-reporting marijuana use. Participants completed a written self-report survey and provided biospecimens at <16weeks gestation (n=46), 18 to 22weeks gestation (n=43), 32 to 36weeks gestation (n=39), and delivery (n=37). Self-reported marijuana use frequency was calculated based on past-monthdays of use multiplied by number of daily uses. Maternal urine and sera were tested for presence (>5ng/mL) of 11-nor-9-carboxy-delta-9-tetrahydrocannabinol (THC-COOH). https://www.selleckchem.com/products/ozanimod-rpc1063.html Liquid chromatography tandem mass spectrometry quantified THC-COOH in umbilical cord homogenate (ng/g). Last marijuana use by any measure was recorded to evaluate the time frame over which THC-COOH remains rine or serum assay. Quantified umbilical cord THC-COOH appears to strongly correlate with frequency of maternal marijuana use in the last month of pregnancy. Earlier use can be measured by either quantitative urine or serum assay. Phthalates are widely used in consumer products in the chemical industries. Due to their abundance in the milieu, their potentially harmful effect on the environment, human and animal health there is a need for sensitive and fast methods for their detection. Positive polarity Corona Discharge Atmospheric Pressure Chemical Ionization (CD-APCI) in the air was applied for ionization of phthalates. The ionization method for the phthalates was studied by atmospheric pressure Ion Mobility Spectrometry (IMS) and hybrid IMS/orthogonal acceleration Time-of-Flight Mass spectrometry (IMS-oaTOF-MS). CD-APCI IMS and MS spectra of selected phthalates (dimethyl phthalate, diethyl phthalate, diethyl isophthalate, diethyl terephthalate, dipropyl phthalate, diisopropyl phthalate, dibutyl phthalate, diisobutyl phthalate, and dibutyl terephthalate) were recorded. In the case of the ortho- and "iso"-isomers exclusively the protonated molecular ions [M+H] were detected. In the case of the para- and meta-isomers and regioisomers, APCI resulted in the appearance of hydrated protonated molecular ions [M + H] ·(H O) . The ion mobilities, collision cross-sections of these ions in air, as well as the limits of detection (LODs) for the phthalate vapors, were determined. In the case of isomeric phthalates, we have demonstrated the potential of the IMS technique for their separation. The results show that CD-APCI in combination with IMS and IMS-oaTOF-MS is a suitable method for the fast and sensitive detection of phthalates with the potential to separate some isomers. The results show that CD-APCI in combination with IMS and IMS-oaTOF-MS is a suitable method for the fast and sensitive detection of phthalates with the potential to separate some isomers.