https://www.selleckchem.com/products/d-1553.html -onset sepsis in FICare in single family rooms was mediated by a reduced use of intravenous catheters and parenteral nutrition.This study investigated the dissimilarity in midlife adults' reports of support they and their spouse provide to their parents-in-law, gender differences in these dissimilarity patterns, and implications of this dissimilarity for marital quality. Middle-aged married participants (n = 164, mean age = 53.96 years) from Wave 2 of the Family Exchanges Study reported on the support they and their spouse provided to at least 1 living parent-in-law. Regression models examined associations of marital satisfaction with support for parents-in-law, evaluations of support for parents-in-law, and spousal dissimilarity in support. Gender differences in own and spousal support for parents-in-law revealed matrilineal focused support among married adults. Spousal dissimilarity in support was negatively associated with marital satisfaction for middle-aged adults. This pattern suggests the importance of a perceived balance in supporting one's spouse's parents for marital quality. © 2020 S. Karger AG, Basel.Molecular mechanisms underlying the development and progression of PanNET are still insufficiently understood. Efficacy of currently approved PanNET therapies is limited. While novel treatment options are being developed, patient stratification permitting more personalized treatment selection in PanNET is yet not feasible since no predictive markers are established. The lack of representative in vitro and in vivo models as well as the rarity and heterogeneity of PanNET are prevailing reasons for this. In this study, we describe an in vitro 3D human primary PanNET culture system as a novel preclinical model for more personalized therapy selection. We present a screening platform allowing multi-center sample collection and drug screening in 3D cultures of human primary PanNET cells. We demonstrate that primary c