© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.Nurse resilience is attracting increasing attention in research and practice. Possession of a high level of resilience is cited as being crucial for nurses to succeed professionally and manage workplace stressors. There is no agreed definition of nurse resilience. A concept analysis was undertaken to examine nurse resilience using a priori selected analysis framework. This concept analysis aims to systematically analyse resilience as it relates to nurses and establish a working definition of nurse resilience. Sixty-nine papers met the search criteria for inclusion. Key attributes of nurse resilience were social support, self-efficacy, work-life balance/self-care, humour, optimism, and being realistic. Resilience enables nurses to positively adapt to stressors and adversity. It is a complex and dynamic process which varies over time and context and embodies both individual attributes and external resources. Sustaining nurse resilience requires action and engagement from both individuals and organizations. © 2020 Australian College of Mental Health Nurses Inc.Liquid crystalline block copolymers (LCBCPs) are promising for developing functional materials owing to assembly of better functionality. Taking advantage of difference in reactivity between alkynyl and vinyl over temperature during hydrosilylation, a series of LCBCPs with modular functionalization of block copolymers (BCPs) are reported by independently and site-selectively attaching azobenzene moieties containing alkynyl (LC1) and Si-H (LC2) terminals into well-designed poly(styrene)-block-polybutadienes (PS-b-PBs) and poly(4-vinylphenyldimethylsilane)-block-polybutadienes (PVPDMS-b-PBs) produced from living anionic polymerization (LAP). By the principle of modular functionalization, it is demonstrated that mono-functionalized (PVPDMS-g-LC1)-b-PB and PS-b-(PB-g-LC2) not only maintain independence but also have cooperative contributions to bi-functionalized (PVPDMS-g-LC1)-b-(PB-g-LC2) in terms of mesomorphic performances and microphase separation, which is evident from DSC and POM and identified by powder X-ray diffractions. With the application of new principle of modular functionalization, local-crosslinked liquid crystalline networks (LCNs) with controlled functionality are successfully synthesized, which show well-controlled phase behaviors over molecular compositions. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.Both ceritinib (CER) and PD-1/PD-L1 have brought significant breakthrough for ALK-rearranged non-small-cell lung cancer (NSCLC). However, the overall clinical efficacy of either CER or PD-1/PD-L1 inhibitor monotherapy has been limited to a large extent. Besides, the antitumor effect of combined CER with PD-L1 inhibitor in ALK-rearranged NSCLC are not fully understood. In H2228 cells, we examined the tumor killing effect of CER plus PD-L1 inhibitor in vitro by quantitative RT-PCR, flow cytometry, ELISA, western blotting, peripheral blood mononuclear cells (PBMC) co-culture system, plasmid and transfection experiments. Then, a Ba/F3 (EML4-ALK-WT) xenograft mice model was utilized to further evaluate the synergistic anticancer effects of CER and PD-L1 inhibitor in vivo. Co-culture system of PBMC with H2228 cell promotes the expression of PD-L1 and phospho-ERK, and combination treatments facilitate lymphocyte proliferation and activation, inhibit PD-L1 expression, and enhance lymphocyte cytotoxicity and cell death. In the in vivo NSCLC xenograft model, the tumor volumes of combination were significant smaller than that either CER or PD-L1 treatment. Besides, the relative tumor growth inhibitions were 84.9%, 20.0% and 91.9% for CER, PD-L1 inhibitor and CER plus PD-L1 group, respectively. CER could synergize with PD-1/PD-L1 blockade to yield enhanced anti-tumor responses along with favorable tolerability of adverse effects. CER and PD-L1 inhibitor combined produced a synergistic antineoplastic efficacy in vitro and in vivo, which provide a key insight and proof of principle for evaluating CER plus PD-L1 blockade as combination therapy in clinical therapeutic practice. This article is protected by copyright. All rights reserved.Elements in the medullary ventral respiratory column nuclei and dorsal respiratory group interact with the Kölliker-Fuse and medial parabrachial nuclei to generate the breathing rhythm and pattern. Triphasic eupnea consists of inspiratory [I], post-inspiratory [post-I], and late-expiratory [E2] phases. Mesencephalic zones exert modulatory influences upon respiratory rhythm generating circuitry, sympathetic oscillators, and parasympathetic nuclei. The earliest evidence supporting this derives from studies performed by Martin and Booker in 1878. These authors demonstrated augmentation of ventilation in response to electrical stimulation of the mesencephalic colliculi in the rabbit.  https://www.selleckchem.com/products/oprozomib-onx-0912.html  A series of studies performed during the past several decades revealed a critical contribution of the red nucleus in mediating hypoxic ventilatory depression. Stimulation of distributed zones within the midbrain elicited seemingly disparate effects upon respiratory phase timing and transitioning. The works of Schmid and Böhmer demonsc and polysynaptic propriobulbar and bulbospinal circuitry mediating periaqueductal gray matter and collicular modulation of breathing and autonomic outflow. The periaqueductal gray matter thus modulates and shapes neural respiratory frequency and amplitude, respiratory phase transitions, and autonomic outflow and appropriately coordinates defense reaction behavioral responses. The data collectively inspire fruitful new avenues of investigation in order to more thoroughly elucidate the mechanistic underpinnings of coordinate effects of the mesencephalic periaqueductal gray matter modulating the cardiovascular and respiratory outputs. We discuss and review the literature evaluating the role of the periaqueductal gray matter in modulating the respiratory and cardiovascular outputs. This article is protected by copyright. All rights reserved.The goals of imaging after neoadjuvant therapy for breast cancer are to monitor the response to therapy and facilitate surgical planning. MRI has been found to be more accurate than mammography, ultrasound, or clinical exam in evaluating treatment response. However, MRI may both overestimate and underestimate residual disease. The accuracy of MRI is dependent on tumor morphology, histology, shrinkage pattern, and molecular subtype. Emerging MRI techniques that combine functional information such as diffusion, metabolism, and hypoxia may improve MR accuracy. In addition, machine-learning techniques including radiomics and radiogenomics are being studied with the goal of predicting response on pretreatment imaging. This article comprehensively reviews response assessment on breast MRI and highlights areas of ongoing research. LEVEL OF EVIDENCE 3 TECHNICAL EFFICACY STAGE 3. © 2020 International Society for Magnetic Resonance in Medicine.