17; 95% confidence interval [CI], 2.99-8.95) independent of age, sex, body mass index, hypertension, cerebrovascular/cardiovascular disease, smoking, drinking alcohol, education, cognitive function, objective oral health (dentition status) and oral health behaviour (dental visit within 1year). Similarly, impaired OHRQoL predicted the development of depressive symptoms within 4years in a fully adjusted longitudinal model (OR, 6.00; 95% CI, 1.38-26.09).
 
  Impaired OHRQoL was identified as a potential comorbidity of depressive symptoms and a predictor for depressive disorder later in life. OHRQoL may be a useful clinical outcome for elder patients with regard to their mental and oral health.
 Impaired OHRQoL was identified as a potential comorbidity of depressive symptoms and a predictor for depressive disorder later in life. OHRQoL may be a useful clinical outcome for elder patients with regard to their mental and oral health.As a major carbon emitter, the electricity sector is crucial to the realization of China's emission reduction objectives. Existing studies focus mostly on the influencing factors, emission efficiency and low carbon development of carbon emissions in the electricity sector. Missing from the literature is an analysis of spatial characteristics of carbon emissions and the embodied carbon emission transfer caused by the separation of electricity production and consumption, which is the basis for assigning the responsibility for emission reduction. Thirty provinces in China were taken as research objects, and Moran's I index was adopted to analyze the spatial characteristics of the electricity sector's carbon emissions and carbon emission intensity. Based on multiregional input-output tables, we compared the transfer situation of China's provincial electricity carbon emissions in 2010 and 2015. The results demonstrate that, from 2010 to 2015, the electricity carbon emissions in 20 provinces increased, whereas the carbon emission intensity in 21 provinces decreased. Carbon emissions and carbon emission intensity of electricity in most provinces demonstrate positive spatial clustering characteristics. The total amount of carbon emission transfer in the electricity sector increased from 421.22 million tons in 2010 to 581.369 million tons in 2015, the number of net transfers out of areas increased from 13 to 15, and the number of net transfers into areas decreased from 16 to 15. The active degree of carbon emission transfer reveals the eastern region > the central region > the western region. Different emission reduction policies should be formulated based on the difference in resource endowment between the north and south. Provinces that transferred out large amounts of electricity carbon emissions should take greater responsibility for emission reduction. Integr Environ Assess Manag 2021;001-16. © 2021 SETAC.Aneuploidy is the leading cause of miscarriage and congenital birth defects, and a hallmark of cancer. Despite this strong association with human disease, the genetic causes of aneuploidy remain largely unknown. Through exome sequencing of patients with constitutional mosaic aneuploidy, we identified biallelic truncating mutations in CENATAC (CCDC84). We show that CENATAC is a novel component of the minor (U12-dependent) spliceosome that promotes splicing of a specific, rare minor intron subtype. This subtype is characterized by AT-AN splice sites and relatively high basal levels of intron retention. CENATAC depletion or expression of disease mutants resulted in excessive retention of AT-AN minor introns in ˜ 100 genes enriched for nucleocytoplasmic transport and cell cycle regulators, and caused chromosome segregation errors. Our findings reveal selectivity in minor intron splicing and suggest a link between minor spliceosome defects and constitutional aneuploidy in humans.
  The association between the quantitative flow ratio (QFR) and adverse events after drug-coated balloon (DCB) angioplasty for in-stent restenosis (ISR) lesions has not been investigated.
 
  Post-procedural QFR is related to adverse events in patients undergoing DCB angioplasty for ISR lesions.
 
  This retrospective study included data from patients undergoing DCB angioplasty for drug-eluting stent (DES) ISR between January 2016 and February 2019. The QFR was measured at baseline and after DCB angioplasty. The endpoint was the vessel-oriented composite endpoint (VOCE), defined as a composite of cardiac death, vessel-related myocardial infarction, and ischemia-driven target vessel revascularization.
 
  Overall, 177 patients with 185 DES-ISR lesions were included. During 1-year follow-up, 27 VOCEs occurred in 26 patients. The area under curve (AUC) of the post-procedural QFR was statistically greater than that of the in-stent percent diameter stenosis (0.77, 95% confidence interval [CI] 0.67-0.87 vs.  https://www.selleckchem.com/products/vbit-4.html  0.64, 95% CI 0.53-0.75; p = .032). Final QFR cutoff of 0.94 has the best predictive accuracy for VOCE. A QFR > 0.94 was associated with a lower risk of VOCE compared to a QFR ≤ 0.94 (log-rank test, p < .0001). Survival analysis using the multivariable Cox model showed that a post-procedural QFR ≤ 0.94 was an independent predictor of 1-year VOCE (hazard ratio 6.53, 95% CI 2.70-15.8, p < .001).
 
  A lower QFR value was associated with worse clinical outcomes at 1 year after DCB angioplasty for DES-ISR.
 A lower QFR value was associated with worse clinical outcomes at 1 year after DCB angioplasty for DES-ISR.
  Motivational interviewing (MI) is an evidence-based method of promoting oral healthcare behaviour. Conventional training of MI is a time-consuming and costly aspect in the dental curriculum. Therefore, the aim of this study was to evaluate the effectiveness and acceptance of a MI-blended learning programme for dental students.
 
  Dental students had to perform an interdisciplinary created "ecourse Motivational Interviewing in medical settings" (eMI-med). After completion, patient-student interviews were recorded and evaluated using the Motivational Interviewing Treatment Integrity Code (MITI-d). Furthermore, the students' self-efficacy regarding smoking cessation and oral hygiene motivation was examined and the acceptance of the tool was enquired.
 
  Forty interviews with 25 different students were analysed with the MITI-d. Students showed high levels of MI-adherent behaviour (15.45±6.98), open-ended questions (9.95±6.90) and reflections (10.43±8.85), which were comparable to previous classroom trainings. In addition, 90% of the students preferred e-learning over classroom teaching.