A biomimetic-based approaches, especially with artificial scaffolding, have established great potential to provide tissue regeneration capacity and an effective way to bridge the gap between host cell responses and organ demands. However, the synthesis of biomaterial is most efficient when the functional behavior involved most resembles the natural extracellular matrix. Here, a fibrous scaffold was engineered by integrating zein and chitosan (CS) in to polyurethane (PU) associated with functionalized multiwalled carbon nanotubes (fMWCNTs) as a bone cell repair material. The chitosan-based, tissue-engineered scaffold containing 0.1 mg/mL fMWCNTs shows potent synergistic results where improved biomechanical strength, hydrophilicity and antibacterial efficacy produce a scaffold akin to a truly natural extracellular matrix found in the bone cell microenvironments. The scaffold enables rapid cell-to-cell communication through a bio-interface and greatly promotes the regenerative effect of pre-osteoblast (MC3T3-E1) which is reflected in terms of cell growth, proliferation, and differentiation in our in vitro experiments. Alizarin red staining analysis, alkaline phosphatase activity, and Western blotting also confirm the nucleation of hydroxyapatite (HA) nanocrystals and the expression of osteogenic protein markers, all of which indicate the scaffold's excellent osteoinductive properties. These results suggest that this precisely engineered PU/Zein/CS-fMWCNTs fibrous scaffold possesses suitable biological behavior to act as an artificial bone extracellular matrix that will ensure bone cell regeneration while contributing numerous benefits to the field of artificial bone grafts.Antithrombotic drugs have some side effects, such as risk of serious bleeding. Development of antithrombotic drugs that inhibit components of the intrinsic coagulation pathway and have a low risk of causing bleeding has recently been a focus of research. Fucosylated glycosaminoglycan (FG), also named as fucosylated chondroitin sulfate (FCS), has potent anticoagulant activity and inhibits intrinsic factor tenase (FXase) complex. Low-molecular-weight FG (LFG) and its oligosaccharides show characteristics of anticoagulant and antithrombotic activities with negligible side effects, such as activation of human FXII, induction of platelet aggregation, and especially, the risk of serious bleeding. They are potential new anticoagulant drugs and have been extensively studied in recent years. This review presents recent findings regarding the preparation, structural analysis, pharmacological activity, and structure-activity relationships of LFG and its derived oligosaccharides, so as to provide a reference for the development of new anticoagulants with low side effects.Biopolymer-based membranes are at the forefront of the guided bone regeneration (GBR) in orthopaedics and dentistry, which prevent fast-growing soft tissue migration to the defected alveolar ridge or implants and allow the bone regeneration. In this study, we fabricated a novel Janus -two-faced, GBR membrane composed of a chitin nanofiber face for bone regeneration and a cell membrane mimetic antifouling 2-Methacryloyloxyethyl phosphorylcholine (MPC) polymeric face for suppressing the migration of the soft tissue. In vitro cell study showed a higher cell proliferation rate of osteoblast cells on the chitin nanofiber surface and a lower proliferation rate of fibroblasts cells on the antifouling MPC side. An increased of Alkaline Phosphatase (ALP) rate was observed in the chitin nanofiber face, indicating the ability to maintain proliferation and differentiation of osteogenic cells. These results suggest the biomimetic Janus chitin membrane may have the potential to develop as an advance GBR membrane.A novel amphiphilic agar with high transparency and freeze-thaw stability was prepared using octenyl succinic anhydride (OSA). Fourier transform infrared spectroscopy and nuclear magnetic resonance spectroscopy confirmed that the hydrophobic OS groups were successfully introduced in OSA-modified agar (OSAR) backbone.  https://www.selleckchem.com/products/vit-2763.html  The OSAR showed higher emulsion stability and oil loading capacity than the native agar (NA). Compared with gel transparency (47.1 %), syneresis (42.1 %) of NA, OSAR exhibited high gel transparency (80 %) and low syneresis (3.3 %) when the degree of substitution (DS) was 0.06 and 0.12, respectively. Meanwhile, the OSAR showed a decreased interface tension and average molecular weight after modification. Thermogravimetric analysis indicated the thermal stability of OSAR was decreased, while texture profile analysis showed the springiness of the OSAR gel was enhanced. Dynamic rheology measurements revealed the OSAR with low gel strength displayed more liquid-like properties. Moreover, the OSAR exhibited lower turbidity and melting temperatures than the NA.This study aims to assess Na2CO3 treatment as a potential pre-treatment for extracting cellulose micro-fibers and subsequently cellulose nano-fibrils (CNF) from sugarcane bagasse. For cellulose micro-fibers extraction, Na2CO3 concentration, reaction time, and temperature were critical factors influencing reaction kinetics. It was concluded from statistical analysis of crystallinity index (CrI) that temperature was the most significant factor. Moreover, reaction time and Na2CO3 concentration were minimized while maximizing temperature to get an increase of 33 % and 115.2 % in the CrI and activation energy of thermal degradation, respectively. FTIR analysis of cellulose micro-fibers indicated the removal of hemicellulose and lignin. For the preparation of CNF, ionic liquid (IL) 1-n-butyl-3-methylimidazolium chloride was used. The CNF diameter was in the range of 4-35 nm, and the length was in a few micrometers. Hence Na2CO3 treatment in the combination of IL treatment is an efficient and environmentally friendly approach to valorize sugarcane bagasse into high-value CNF.For the first time, this study demonstrates a direct extraction of carboxylated cellulose nanocrystals (c-CNCs) from recycled medium density fiberboard (r-MDF) fibers by ammonium persulfate (APS) without any chemical pre-treatment. The aim of this research was to find an optimum condition for isolating c-CNCs from r-MDF fibers by studying the effect of reaction parameters on the characteristics of c-CNCs. The rod-like c-CNCs had an average length and width of 170 to 365 nm and 13 to 17 nm, leading to an aspect ratio of 13∼21. The optimum conditions for a maximum yield and crystallinity were obtained at a reaction temperature of 70 °C, reaction time of 16 h and APS concentration of 1.5 mol L-1. Thermal analysis also revealed lower thermal stability of the c-CNCs compared to r-MDF fibers. The APS oxidation is a viable option for converting r-MDF fibers into value-added c-CNCs.