Current research examined the differential effects of pills' shape (angular vs. curvy) on the perceived efficacy of the medicine, evoked bodily sensations and emotions. We investigated these effects by using different types of angular vs. curved stimuli abstract drawn shapes (Study 1), 3D-printed mockup pills (Study 2) and photographs of the existing pills (Study 3). Participants were asked to imagine 'taking' angular and curved pills. They had to focus on the bodily sensations and report the evoked activations/deactivations in different body parts. Across three studies, we found that the angular pills evoke overall more activations in the body compared to curvy pills. We further reported differences in the topography of angular vs. curved pills'-triggered sensations in different body parts. Our results also revealed that angularity is linked with an energizing effect while roundness is associated with a calming effect. The shape effects were demonstrated not only in self-reported energized vs. calm subjective feelings but also in performance on a timed cognitive test. Compared to incongruent designs, pill designs (angular vs. curved) congruent with proposed drug benefits (energizing vs.  https://www.selleckchem.com/products/r-hts-3.html  calming) were perceived as more effective. Moreover, we found differences in emotions triggered by pills of different shapes. The present research provided new findings on angularity vs. curvature perception that may be valuable for cognitive psychology, marketing, pharmaceutical and supplements industry, and other applied fields.Measuring the performance of information security is an essential part of the information security management system within organisations. Studies in the past mainly focused on establishing qualitative measurement approaches. Since these can lead to ambiguous conclusions, quantitative metrics are being increasingly proposed as a useful alternative. Nevertheless, the literature on quantitative approaches remains scarce. Thus, studies on the evaluation of information security performance are challenging, especially since many approaches are not tested in organisational settings. The paper aims to validate the model used for evaluating the performance of information security management system through a multidimensional socio-technical approach, in a real-world settings among medium-sized enterprises in Slovenia. The results indicate that information security is strategically defined and compliant, however, measures are primarily implemented at technical and operational levels, while its strategic management remains underdeveloped. We found that the biggest issues are related to information resources and risk management, where information security measurement-related activities proved to be particularly problematic. Even though enterprises do possess certain information security capabilities and are aware of the importance of information security, their current practices make it difficult for them to keep up with the fast-paced technological and security trends.In HIV-hepatitis B virus (HBV) co-infection, adverse liver outcomes including liver fibrosis occur at higher frequency than in HBV-mono-infection, even following antiretroviral therapy (ART) that suppresses both HIV and HBV replication. To determine whether liver disease was associated with intrahepatic or circulating markers of inflammation or burden of HIV or HBV, liver biopsies and blood were collected from HIV-HBV co-infected individuals (n = 39) living in Bangkok, Thailand and naïve to ART. Transient elastography (TE) was performed. Intrahepatic and circulating markers of inflammation and microbial translocation were quantified by ELISA and bead arrays and HIV and HBV infection quantified by PCR. Liver fibrosis (measured by both transient elastography and liver biopsy) was statistically significantly associated with intrahepatic mRNA for CXCL10 and CXCR3 using linear and logistic regression analyses adjusted for CD4 T-cell count. There was no evidence of a relationship between liver fibrosis and circulating HBV DNA, qHBsAg, plasma HIV RNA or circulating cell-associated HIV RNA or DNA. Using immunohistochemistry of liver biopsies from this cohort, intrahepatic CXCL10 was detected in hepatocytes associated with inflammatory liver infiltrates in the portal tracts. In an in vitro model, we infected an HBV-infected hepatocyte cell line with HIV, followed by interferon-γ stimulation. HBV-infected cells lines produced significantly more CXCL10 than uninfected cells lines and this significantly increased in the presence of an increasing multiplicity of HIV infection. Conclusion Enhanced production of CXCL10 following co-infection of hepatocytes with both HIV and HBV may contribute to accelerated liver disease in the setting of HIV-HBV co-infection.Nowadays, citizen science has become increasingly popular, especially in Western countries. In Hong Kong, citizen science projects are mostly used for public education, while utilizing citizen scientists in published scientific research is very rare. On the other hand, with the increasing threats to global water security, Hong Kong requires new adaptation and strategy in facing the impairment of local freshwater systems. However, unfortunately, the number of full-scale urban river research appears to be declining. In this regard, citizen science can offer an alternative option as one of the new integrated water management strategies in Hong Kong. In this study, the water quality of seven rivers and streams in Hong Kong was studied monthly for two years by a group of citizen scientists. The main goal is to examine the reliability of data collected by citizen scientists by comparing it with the official data from the Environmental Protection Department of Hong Kong (EPD). Results show that the water temperature and conductivity data acquired by the citizen scientists were highly comparable to the official data. Also, moderate to strong correlations in water pH, turbidity, and dissolved oxygen levels were found between citizen scientists and official data. Since the citizen science data remained as high as 70% of relevance to the official data, we believe that this may serve as a supplement to the lacking official or professional water quality monitoring data in Hong Kong. Even though the use of volunteer data in water quality monitoring unavoidably exists with errors and bias, this study demonstrates a successful outcome of utilizing citizen science programme in urban river monitoring in Hong Kong.