Hollow fiber membrane contactors (HFMCs) can effectively separate CO2 from post-combustion flue gas by providing a high contact surface area between the flue gas and a liquid solvent. Accurate models of carbon capture HFMCs are necessary to understand the underlying transport processes and optimize HFMC designs. There are various methods for modeling HFMCs in 1D, 2D, or 3D. These methods include (but are not limited to) resistance-in-series, solution-diffusion, pore flow, Happel's free surface model, and porous media modeling. This review paper discusses the state-of-the-art methods for modeling carbon capture HFMCs in 1D, 2D, and 3D. State-of-the-art 1D, 2D, and 3D carbon capture HFMC models are then compared in depth, based on their underlying assumptions. Numerical methods are also discussed, along with modeling to scale up HFMCs from the lab scale to the commercial scale.We sought to determine if DNA methylation patterns differed between vegans and non-vegetarians in the Adventist Health Study-2 cohort. Genome-wide DNA methylation derived from buffy coat was profiled in 62 vegans and 142 non-vegetarians. Using linear regression, methylation of CpG sites and genes was categorized or summarized according to various genic/intergenic regions and CpG island-related regions, as well as the promoter. Methylation of genes was measured as the average methylation of available CpG's annotated to the nominated region of the respective gene. A permutation method defining the null distribution adapted from Storey et al. was used to adjust for false discovery. Differences in methylation of several CpG sites and genes were detected at a false discovery rate less then 0.05 in region-specific and overall analyses. A vegan diet was associated predominantly with hypomethylation of genes, most notably methyltransferase-like 1 (METTL1). Although a limited number of differentially methylated features were detected in the current study, the false discovery method revealed that a much larger proportion of differentially methylated genes and sites exist, and could be detected with a larger sample size. Our findings suggest modest differences in DNA methylation in vegans and non-vegetarians, with a much greater number of detectable significant differences expected with a larger sample.Shared-decision making for head and neck squamous cell carcinoma (HNSCC) is challenged by the difficulty to integrate the patient perception of value within the framework of a multidisciplinary team approach. The aim of this study was to develop a questionnaire to assess the preferences of HNSCC patients with respect to the disease trajectory, expected treatment, and toxicities. In accordance with the standardized EORTC Quality of Life Group's methodology for the development of quality of life modules, a phase 1-2 study was envisaged. Following a systematic review of the literature, a consolidated list of 28 issues was administered through a semi-structured interview to 111 patients from 7 institutions in 5 countries. Overall, "cure of disease", "survival", and "trusting in health care professionals" were the 3 most common priorities, being chosen by 87.3%, 73.6% and 59.1% of patients, respectively. When assessing the correlation with the treatment subgroup, the issue of "being thoroughly and sincerely informed about treatments' efficacy and survival expectation" was highly prevalent in an independent manner (71.4%, 75% and 90% of patients in the follow-up, palliative and curative subgroups, respectively). Based on prespecified scoring criteria, a 24-item list was generated. Pending clinical applicability, further testing and validation of the questionnaire are warranted.Abnormal uterine function affects conception rate and embryo development, thereby leading to poor fertility and reproduction failure. Exosomes are a nanosized subclass of extracellular vesicles (EV) that have important functions as intercellular communicators. They contain and carry transferable bioactive substances including micro RNA (miRNA) for target cells. Elements of the cargo can provide epigenetic modifications of the recipient cells and may have crucial roles in mechanisms of reproduction. The dairy industry accounts for a substantial portion of the economy of many agricultural countries. Exosomes can enhance the expression of inflammatory mediators in the endometrium, which contribute to various inflammatory diseases in transition dairy cows. This results in reduced fertility which leads to reduced milk production and increased cow maintenance costs. Thus, gaining a clear knowledge of exosomal epigenetic modifiers is critical to improving the breeding success and profitability of dairy farms. This review provides a brief overview of how exosomal miRNA contributes to inflammatory diseases and hence to poor fertility, particularly in dairy cows.Recently, many platforms have outsourced tasks to numerous smartphone devices known as Mobile Crowd-sourcing System (MCS). The data is collected and transferred to the platform for further analysis and processing. These data needs to maintain confidentiality while moving from smartphones to the platform.  https://www.selleckchem.com/products/elexacaftor.html  Moreover, the limitations of computation resources in smartphones need to be addressed to balance the confidentiality of the data and the capabilities of the devices. For this reason, elliptic curve cryptography (ECC) is accepted, widespread, and suitable for use in limited resources environments such as smartphone devices. ECC reduces energy consumption and maximizes devices' efficiency by using small crypto keys with the same strength of the required cryptography of other cryptosystems. Thus, ECC is the preferred approach for many environments, including the MCS, Internet of Things (IoT) and wireless sensor networks (WSNs). Many implementations of ECC increase the process of encryption and/or increase the space overhead by, for instance, incorrectly mapping points to EC with extra padding bits. Moreover, the wrong mapping method used in ECC results in increasing the computation efforts. This study provides comprehensive details about the mapping techniques used in the ECC mapping phase, and presents performance results about widely used elliptic curves. In addition, it suggests an optimal enhanced mapping method and size of padding bit to secure communications that guarantee the successful mapping of points to EC and reduce the size of padding bits.